From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
DNA2-like helicase is an
enzyme that in humans is encoded by the DNA2
gene .
[5]
[6]
[7] Dna2, a
homolog of DNA2KL present in
budding yeast , possesses both
helicase and
nuclease activity, with which it helps catalyze early steps in
homologous recombination .
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000138346 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000036875 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Eki T, Okumura K, Shiratori A, Abe M, Nogami M, Taguchi H, Shibata T, Murakami Y, Hanaoka F (Mar 1997). "Assignment of the closest human homologue (DNA2L:KIAA0083) of the yeast Dna2 helicase gene to chromosome band 10q21.3-q22.1". Genomics . 37 (3): 408–10.
doi :
10.1006/geno.1996.0581 .
PMID
8938459 .
^ Masuda-Sasa T, Polaczek P, Campbell JL (Dec 2006).
"Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation" . J Biol Chem . 281 (50): 38555–64.
doi :
10.1074/jbc.M604925200 .
PMID
17032657 .
^
"Entrez Gene: DNA2L DNA2 DNA replication helicase 2-like (yeast)" .
^ Mimitou, EP; Symington, LS (May 2009). "Nucleases and helicases take center stage in homologous recombination". Trends in Biochemical Sciences . 34 (5): 264–272.
doi :
10.1016/j.tibs.2009.01.010 .
PMID
19375328 .
Further reading
Masuda-Sasa T, Imamura O, Campbell JL (2006).
"Biochemical analysis of human Dna2" . Nucleic Acids Res . 34 (6): 1865–75.
doi :
10.1093/nar/gkl070 .
PMC
1428797 .
PMID
16595800 .
Kim JH, Kim HD, Ryu GH, et al. (2006).
"Isolation of human Dna2 endonuclease and characterization of its enzymatic properties" . Nucleic Acids Res . 34 (6): 1854–64.
doi :
10.1093/nar/gkl102 .
PMC
1428795 .
PMID
16595799 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004).
"The DNA sequence and comparative analysis of human chromosome 10" . Nature . 429 (6990): 375–81.
Bibcode :
2004Natur.429..375D .
doi :
10.1038/nature02462 .
PMID
15164054 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Nagase T, Miyajima N, Tanaka A, et al. (1995).
"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1" . DNA Res . 2 (1): 37–43.
doi :
10.1093/dnares/2.1.37 .
PMID
7788527 .