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For other uses, see David (disambiguation).
DAVID Bioinformatics Resources
Stable release
2021.2024q1 / January 2024; 4 months ago (2024-01)
Type Bioinformatics
License Freeware [1]
Website david.ncifcrf.gov

DAVID (the database for annotation, visualization and integrated discovery) is a free online bioinformatics resource developed by the Laboratory of Human Retrovirology and Immunoinformatics ( LHRI). [2] [3] [4] [5] [6] [7] All tools in the DAVID Bioinformatics Resources aim to provide functional interpretation of large lists of genes derived from genomic studies, e.g. microarray and proteomics studies. DAVID can be found at https://david.ncifcrf.gov/

The DAVID Bioinformatics Resources consists of the DAVID Knowledgebase and five integrated, web-based functional annotation tool suites: the DAVID Gene Functional Classification Tool, the DAVID Functional Annotation Tool, the DAVID Gene ID Conversion Tool, the DAVID Gene Name Viewer and the DAVID NIAID Pathogen Genome Browser. The expanded DAVID Knowledgebase now integrates almost all major and well-known public bioinformatics resources centralized by the DAVID Gene Concept, a single-linkage method to agglomerate tens of millions of diverse gene/protein identifiers and annotation terms from a variety of public bioinformatics databases. For any uploaded gene list, the DAVID Resources now provides not only the typical gene-term enrichment analysis, but also new tools and functions that allow users to condense large gene lists into gene functional groups, convert between gene/protein identifiers, visualize many-genes-to-many-terms relationships, cluster redundant and heterogeneous terms into groups, search for interesting and related genes or terms, dynamically view genes from their lists on bio-pathways and more.

DAVID 2021 update was released in December 2021. [8] The knowledgebase has been scheduled to update quarterly.

Functionality

DAVID provides a comprehensive set of functional annotation tools for investigators to understand biological meaning behind large list of genes. For any given gene list, DAVID tools are able to:

  • Identify enriched biological themes, particularly GO terms
  • Discover enriched functional-related gene groups
  • Cluster redundant annotation terms
  • Visualize genes on BioCarta & KEGG pathway maps
  • Display related many-genes-to-many-terms on 2-D view.
  • Search for other functionally related genes not in the list
  • List interacting proteins
  • Explore gene names in batch
  • Link gene-disease associations
  • Highlight protein functional domains and motifs
  • Redirect to related literatures
  • Convert gene identifiers from one type to another.

External links

References

  1. ^ "License: Users from academic, non-profit and government institutes may freely use EASE". Archived from the original on 2011-10-15. Retrieved 2012-02-04.
  2. ^ Huang DW, Lempicki RA (2009). "Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources". Nature Protocols. 4 (1): 44–57. doi: 10.1038/nprot.2008.211. PMID  19131956. S2CID  10418677.
  3. ^ Sherman BT, Huang DW, Tan Q, Guo Y, Bour S, Liu D, Stephens R, Baseler MW, Lane HC, Lempicki RA (2007). "DAVID Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis". BMC Bioinformatics. 8: 426. doi: 10.1186/1471-2105-8-426. PMC  2186358. PMID  17980028.
  4. ^ Huang DW, Sherman BT, Tan Q, Collins JR, Alvord WG, Roayaei J, Stephens R, Baseler MW, Lane HC, Lempicki RA (2007). "The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists". Genome Biol. 8 (9): R183. doi: 10.1186/gb-2007-8-9-r183. PMC  2375021. PMID  17784955.
  5. ^ Huang Da, HC; Sherman, BT; Tan, Q; Kir, J; Liu, D; Bryant, D; Guo, Y; Stephens, R; et al. (2007). "DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists". Nucleic Acids Research. 35 (Web Server issue): W169–75. doi: 10.1093/nar/gkm415. PMC  1933169. PMID  17576678.
  6. ^ Hosack; Dennis Jr, G; Sherman, BT; Lane, HC; Lempicki, RA (2003). "Identifying biological themes within lists of genes with EASE". Genome Biology. 4 (10): R70. doi: 10.1186/gb-2003-4-10-r70. PMC  328459. PMID  14519205.
  7. ^ Dennis Jr; Sherman, BT; Hosack, DA; Yang, J; Gao, W; Lane, HC; Lempicki, RA (2003). "DAVID: Database for Annotation, Visualization, and Integrated Discovery". Genome Biology. 4 (5): P3. doi: 10.1186/gb-2003-4-5-p3. PMC  193660. PMID  12734009.
  8. ^ Release & Version Information, DAVID Bioinformatics Resources.
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