From Wikipedia, the free encyclopedia
D75-4590
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Names
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IUPAC name
1-{[2-(Diethylamino)ethyl]amino}-2-ethyl-3-methylpyrido[1,2-a]benzimidazole-4-carbonitrile
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Other names
4-[2-(Diethylamino)ethylamino]-3-ethyl-2-methyl-4a,9-diaza-3,4-dihydrofluorene-1-carbonitrile
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Identifiers
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ChEMBL
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ChemSpider
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UNII
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InChI=1S/C21H27N5/c1-5-16-15(4)17(14-22)21-24-18-10-8-9-11-19(18)26(21)20(16)23-12-13-25(6-2)7-3/h8-11,23H,5-7,12-13H2,1-4H3 Key: DMKNXKIUSPUYQP-UHFFFAOYSA-N
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CCc1c(c(c2nc3ccccc3n2c1NCCN(CC)CC)C#N)C
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Properties
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C21H27N5
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Molar mass
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349.473 g/mol
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Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
D75-4590 is an
antifungal pyridobenzimidazole derivative that inhibits
β-glucan synthesis.
D11-2040 and
D21-6076 are antifungal derivatives of D75-4590.
[1]
[2]
References
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^ Kitamura, Akihiro; Someya, Kazuhiko; Hata, Masato; Nakajima, Ryohei; Takemura, Makoto (2008).
"Discovery of a Small-Molecule Inhibitor of β-1,6-Glucan Synthesis". Antimicrobial Agents and Chemotherapy. 53 (2): 670–7.
doi:
10.1128/AAC.00844-08.
PMC
2630612.
PMID
19015325.
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^ Kitamura, Akihiro; Someya, Kazuhiko; Okumura, Ryo; Hata, Masato; Takeshita, Hiroshi; Nakajima, Ryohei (2010).
"In Vitro Antifungal Activities of D11-2040, a β-1,6-Glucan Inhibitor, with or without Currently Available Antifungal Drugs". Biological & Pharmaceutical Bulletin. 33 (2): 192–7.
doi:
10.1248/bpb.33.192.
PMID
20118539.