From Wikipedia, the free encyclopedia
Clinical endocannabinoid deficiency (CECD) is a medical theory that proposes that a deficiency of
endocannabinoids is the underlying
pathophysiology of
migraines ,
fibromyalgia , and
irritable bowel syndrome .
[1]
[2] The deficiency may sometimes
start in the womb as a result of maternal
obesity .
[3]
The nature of the syndrome and existence of CECD as a clinically meaningful condition have been called into question.
[4]
References
^ Russo, EB (2004). "Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?". Neuro Endocrinology Letters . 25 (1–2): 31–9.
PMID
15159679 .
^ Russo, EB (2016).
"Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes" . Cannabis and Cannabinoid Research . 1 (1): 154–165.
doi :
10.1089/can.2016.0009 .
PMC
5576607 .
PMID
28861491 .
^ Schlabritz-Loutsevitch, N, et al. (2016). "Fetal Syndrome of Endocannabinoid Deficiency (FSECD) in Maternal Obesity". Medical Hypotheses . 96 : 35–38.
doi :
10.1016/j.mehy.2016.09.021 .
PMID
27959272 .
^ Cogan, PS (2020).
"Practical Considerations of Hypotheses and Evidence in Cannabis Pharmacotherapy: Refining Expectations of Clinical Endocannabinoid Deficiency" . Journal of Dietary Supplements . 17 (5): 608–624.
doi :
10.1080/19390211.2020.1769246 .
PMID
32449630 .