Clare Lloyd | |
---|---|
Born | Clare Margaret Lloyd |
Alma mater | King's College London (PhD) |
Scientific career | |
Fields | Inflammation [1] |
Institutions |
Imperial College London Harvard University Millennium Pharmaceuticals |
Thesis | Mechanisms of nephritis during murine malarial infections (1991) |
Website |
imperial |
Clare Margaret Lloyd FRSB FMedSci is a Professor of Medicine and Vice Dean for Institutional Affairs at Imperial College London. She investigates allergic immunity in early life. [1]
Lloyd earned her BSc and PhD in immunology at King's College London. [2] She earned her Bachelor's degree in 1987 and her PhD in 1991. [3] She was awarded a National Kidney Research Fund Fellowship and joined the United Medical and Dental Schools of Guy's and St Thomas' Hospitals. [2] Her work considered mouse models of glomerulonephritis. She joined Harvard University to work on chronic inflammatory glomerulonephritis. [2] She became interested in the mechanisms of cell recruitment. She was involved with early studies that looking at the cloning, expression and function of chemokine. [4] Her group demonstrated that T helper cells were the initial responders to CCR3 and CCR4 pathways, but the increase in CCR4 positive cells results in the long-term representation of T helper cells in vivo. [5] LLoyd studied the role of these chemokines in allergic lung inflammation. [6] She looked to better characterise the spatial patterns of chemokine expression to inform therapeutic strategies that limit the side-effects of allergen exposure. [6]
After her postdoctoral fellowship at Harvard University, Lloyd joined at Millennium Pharmaceuticals in 1996 to work on models to characterise novel genes. [2] She returned to the UK in 1999, joining Imperial College London as a Wellcome Trust Senior Fellow. [2] She continued her interest in allergens, looking at the roles for cells and molecules involved in pulmonary inflammation. [2] She is part of the Asthma UK Centre in Allergic Mechanisms of Asthma. [7] She is a member of the British Society for Immunology and Wellcome Trust Infection, Immunity and Immunophenotyping. [8] Lloyd studies the lung cells of children who suffer from asthma and severe wheeze. [9] She has studied why pollen and dust can trigger reactions in some people but not others. [10] She became interested in why exposure to allergens and infections in early life had such an influence on programming pathways to maintain pulmonary homeostasis. [11] [12] She demonstrated that Interleukin 9 can mediate inflammation of asthma. [13]
She was appointed Professor in Respiratory Immunology in 2006. [2] She is co-lead of the respiratory division. [14] Her research group, the Lloyd Lab, look at the interactions between lung cells and infiltrating inflammatory cells. [15] Lloyd was awarded the Imperial College London Rectors Medal for her Research Supervision in 2014. [16] In 2018, she demonstrated that the ICOS/ICOS‐L pathway could be a therapeutic target in asthma. [17]
She was the lead National Heart and Lung Institute Athena Swan lead between 2009 and 2014, achieving the first Silver award for a medical department in the UK. [18] She pushed for the improvement of the Imperial College London mentoring scheme, in an effort to support early career researchers. [18] In 2016 she was appointed Dean of Institutional Affairs at Imperial College London. [18] She serves on the scientific advisory board of Science Magazine and is an editor of Nature Mucosal Immunology and the European Journal of Immunology. [19] [20] [21] She serves on the Royal Society Newton International Fellowships board. [22]