Chloroethylnorapomorphine is a chemical once thought to be an irreversible
dopamine D2 receptorantagonist;[1][2] however, it was later proved to be reversible.[3]
References
^Cohen SA, Neumeyer J (Oct 1983). "Kinetics of solvolysis of N-(2-chloroethyl)norapomorphine, an irreversible dopamine receptor antagonist". Journal of Medicinal Chemistry. 26 (10): 1348–53.
doi:
10.1021/jm00364a003.
PMID6620296.
^Guan JH, Neumeyer JL, Filer CN, Ahern DG, Lilly L, Watanabe M, Grigoriadis D, Seeman P (Jun 1984). "N-(2-chloroethyl) [8,9-2H]norapomorphine, an irreversible ligand for dopamine receptors: synthesis and application". Journal of Medicinal Chemistry. 27 (6): 806–10.
doi:
10.1021/jm00372a019.
PMID6737423.
^Lehmann, J; Langer, SZ (1982). "Dopamine autoreceptors differ pharmacologically from postsynaptic dopamine receptors: Effects of (−)-N-(2-chloroethyl)-norapomorphine". European Journal of Pharmacology. 77 (1): 85–6.
doi:
10.1016/0014-2999(82)90542-8.
PMID7060630.