The denomination Cathedral of the Most Holy Trinity may refer to:

• Cathedral of the Most Holy Trinity, Bermuda (Anglican)
• Cathedral of the Most Holy Trinity, Buenos Aires (Russian Orthodox)
• Co-Cathedral Basilica of the Most Holy Trinity, Chełmża, Poland (Roman Catholic)
• Cathedral of the Most Holy Trinity, Huancayo, Peru (Roman Catholic)
• Cathedral of the Most Holy Trinity, Montevideo (Anglican)
• Cathedral of the Most Holy Trinity, Waterford (Roman Catholic)
• Cathedral of the Most Holy Trinity (Daet), Philippines (Roman Catholic)
• Cathedral of the Most Holy Trinity (Talibon), Philippines (Roman Catholic)

This disambiguation page lists articles associated with the title Cathedral of the Most Holy Trinity.
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