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The French Wars of Religion refers to a prolonged period of war and popular unrest between Roman Catholics and Huguenots ( Reformed/ Calvinist Protestants) in the Kingdom of France between 1562 and 1598. It is estimated that three million people perished in this period from violence, famine, or disease in what is considered the second deadliest religious war in European history (surpassed only by the Thirty Years' War, which took eight million lives).