Cytochrome P450, family 27, also known as CYP27, is a Deuterostome cytochrome P450 monooxygenase family found in human genome. [1] [2] This family belongs to Mitochondrial clan CYPs, which is located in the inner membrane of mitochondria(IMM). There are three members in the human genome, CYP27A1, CYP27B1 and CYP27C1, [3] and an ortholog CYP27F1 in sea urchins, Strongylocentrotus purpuratus. [4]
References
- ^ Baker, Michael E.; Nelson, David R.; Studer, Romain A. (July 2015). "Origin of the response to adrenal and sex steroids: Roles of promiscuity and co-evolution of enzymes and steroid receptors". The Journal of Steroid Biochemistry and Molecular Biology. 151: 12–24. doi: 10.1016/j.jsbmb.2014.10.020. PMID 25445914. S2CID 21649057.
- ^ Peterson, Julian A; Graham, Sandra E (1998). "A close family resemblance: the importance of structure in understanding cytochromes P450". Structure. 6 (9): 1079–1085. doi: 10.1016/S0969-2126(98)00109-9. PMID 9753700.
- ^ Rendic, Slobodan; Carlo, Frederick J. Di (1997). "Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors". Drug Metabolism Reviews. 29 (1–2): 413–580. doi: 10.3109/03602539709037591. ISSN 0360-2532. PMID 9187528.
- ^ Sea Urchin Genome Sequencing, Consortium.; et al. (10 November 2006). "The genome of the sea urchin Strongylocentrotus purpuratus". Science. 314 (5801): 941–52. Bibcode: 2006Sci...314..941S. doi: 10.1126/science.1133609. hdl: 10447/16293. PMC 3159423. PMID 17095691. S2CID 206508576.
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