CPZ_(gene) References

CPZ
Identifiers
Aliases	CPZ, carboxypeptidase Z
External IDs	OMIM: 603105 MGI: 88487 HomoloGene: 2709 GeneCards: CPZ
Gene location ( Human)
Chr.	Chromosome 4 (human)
End	8,619,759 bp
Gene location ( Mouse)
Chr.	Chromosome 5 (mouse)
End	35,683,042 bp
RNA expression pattern
	Top expressed in
	placenta; ; gallbladder; ; canal of the cervix; ; stromal cell of endometrium; ; vagina; ; uterine tube; ; right uterine tube; ; left uterine tube; ; urinary bladder; ; gastric mucosa;
	Top expressed in
	body of femur; ; calvaria; ; molar; ; skin of back; ; lens; ; urethra; ; cornea; ; skin of abdomen; ; belly cord; ; aortic valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carboxypeptidase activity; zinc ion binding; peptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; metallocarboxypeptidase activity; serine-type carboxypeptidase activity;
Cellular component	extracellular region; extracellular space;
Biological process	protein processing; Wnt signaling pathway; proteolysis; peptide metabolic process;
	Sources: Amigo / QuickGO
Orthologs
	8532
	242939
	ENSG00000109625
	ENSMUSG00000036596
	Q66K79
	Q8R4V4
	NM_003652; NM_001014447; NM_001014448
	NM_153107
	NP_001014447; NP_001014448; NP_003643
	NP_694747
	Wikidata
View/Edit Human	View/Edit Mouse

Carboxypeptidase Z is an enzyme that in humans is encoded by the CPZ gene.^[5]^[6]

This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109625 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036596 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Song L, Fricker LD (May 1997). "Cloning and expression of human carboxypeptidase Z, a novel metallocarboxypeptidase". J Biol Chem. 272 (16): 10543–50. doi: 10.1074/jbc.272.16.10543. PMID 9099699.
^ ^a ^b "Entrez Gene: CPZ carboxypeptidase Z".

External links

Human CPZ genome location and CPZ gene details page in the UCSC Genome Browser.

Reznik SE, Fricker LD (2002). "Carboxypeptidases from A to z: implications in embryonic development and Wnt binding". Cell. Mol. Life Sci. 58 (12–13): 1790–804. doi: 10.1007/PL00000819. PMID 11766880. S2CID 22530649.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Fan X, Olson SJ, Blevins LS, et al. (2003). "Immunohistochemical localization of carboxypeptidases D, E, and Z in pituitary adenomas and normal human pituitary". J. Histochem. Cytochem. 50 (11): 1509–16. doi: 10.1177/002215540205001111. PMID 12417617.
Novikova EG, Reznik SE, Varlamov O, Fricker LD (2000). "Carboxypeptidase Z is present in the regulated secretory pathway and extracellular matrix in cultured cells and in human tissues". J. Biol. Chem. 275 (7): 4865–70. doi: 10.1074/jbc.275.7.4865. PMID 10671522.
Novikova EG, Fricker LD (1999). "Purification and characterization of human metallocarboxypeptidase Z.". Biochem. Biophys. Res. Commun. 256 (3): 564–8. doi: 10.1006/bbrc.1999.0378. PMID 10080937.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109625 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036596 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9099699-5] Song L, Fricker LD (May 1997). "Cloning and expression of human carboxypeptidase Z, a novel metallocarboxypeptidase". J Biol Chem. 272 (16): 10543–50. doi: 10.1074/jbc.272.16.10543. PMID 9099699.

[entrez-6] "Entrez Gene: CPZ carboxypeptidase Z".

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References

External links

Further reading