 | |
| Company type | Private Company |
|---|---|
| Industry | Chemicals, biotechnology |
| Founded | 2001 |
| Headquarters | Sunnyvale, California |
Key people | Shawn Lee (Chairman and Founder), Irvine Skeoch (COO), Xiaohe Tong (Chief Technical Officer) |
| Products | Biopharmaceuticals, research peptides, custom peptides active pharmaceutical ingredients (API), and generics |
| Website |
www |
CPC Scientific is a biotechnology company that manufactures peptides. The company provides a number of products and services to academic researchers and pharmaceutical industries, including research- and GMP-grade custom peptides.
History
Headquartered in Sunnyvale, California, CPC Scientific was founded in 2001 by Dr. Shawn Lee, Ph.D. Product lines initially included research-grade custom peptides, catalog peptides, and Fmoc-protected amino acids. [1] In 2006, CPC Scientific opened a GMP ( Good Manufacturing Practice) facility in Hangzhou, China and began producing GMP-grade peptides for use in clinical applications. By 2011, the GMP facility was inspected by the U.S. Food and Drug Administration (FDA) and the company began supplying pharmaceutical-grade peptides to companies in the United States. On March 17, 2016, CPC Scientific passed a fourth U.S. FDA inspection. [2]
Manufacturing
CPC Scientific manufactures most of their products by way of solid-phase peptide synthesis, a process originally described by Robert Bruce Merrifield in 1963. Solid-phase synthesis routes enable manufacturing of relatively long peptide sequences by avoiding isolation and purification of synthetic intermediates. This iterative process allows for the preparation of more complex peptides for use as active pharmaceutical ingredients (APIs), novel drug therapeutics, and general research applications. CPC Scientific has published some research articles that describe peptide synthesis methodologies, [3] [4] including a technique called hydrocarbon stapling. [5] [6] Stapled peptides contain a synthetic modification that involves olefin metathesis to stabilize alpha-helix and beta-sheet secondary structures. Products manufactured by CPC Scientific have also been cited in scientific journals. [7] [8] [9] [10] [11]
References
- ^ "CPC Scientific Inc. - Profile".
- ^ "CPC Scientific Inc. - fourth US FDA inspection" (Press release).
- ^ Curreli, F.; Haque, K.; Xie, L.; Qiu, Q.; Xu, J.; Yong, W.; Tong, X.; Debnath, A. K. (2015). "Synthesis, antiviral activity and resistance of a novel small molecule HIV-1 entry inhibitor". Bioorganic & Medicinal Chemistry. 23 (24): 7618–7628. doi: 10.1016/j.bmc.2015.11.006. PMC 4684972. PMID 26602829.
- ^ Capon, Daniel J.; Kaneko, Naoki; Yoshimori, Takayuki; Shimada, Takashi; Wurm, Florian M.; Hwang, Peter K.; Tong, Xiaohe; Adams, Staci A.; Simmons, Graham; Sato, Taka-Aki; Tanaka, Koichi (2011). "Capon, Daniel J., et al. "Flexible antibodies with nonprotein hinges." Proceedings of the Japan Academy, Series B 87.9 (2011): 603-616". Proceedings of the Japan Academy, Series B. 87 (9): 603–616. doi: 10.2183/pjab.87.603. PMC 3309923. PMID 22075761.
- ^ Phillips, Chris; Roberts, Lee R.; Schade, Markus; Bazin, Richard; Bent, Andrew; Davies, Nichola L.; Moore, Rob; Pannifer, Andrew D.; Pickford, Andrew R.; Prior, Stephen H.; Read, Christopher M.; Scott, Andrew; Brown, David G.; Xu, Bin; Irving, Stephen L. (2011). "Design and Structure of Stapled Peptides Binding to Estrogen Receptors". Journal of the American Chemical Society. 133 (25): 9696–9699. doi: 10.1021/ja202946k. PMID 21612236.
- ^ Zhang, Hongtao; Curreli, Francesca; Waheed, Abdul A.; Mercredi, Peter Y.; Mehta, Mansi; Bhargava, Pallavi; Scacalossi, Daniel; Tong, Xiaohe; Lee, Shawn; Cooper, Alan; Summers, Michael F.; Freed, Eric O.; Debnath, Asim K. (2013). "Dual-acting stapled peptides target both HIV-1 entry and assembly". Retrovirology. 10: 136. doi: 10.1186/1742-4690-10-136. PMC 3842668. PMID 24237936.
- ^ "Sharma, Rajesh K., et al. "Costimulation as a platform for the development of vaccines: a peptide-based vaccine containing a novel form of 4-1BB ligand eradicates established tumors." Cancer research 69.10 (2009): 4319-4326".
- ^ Mentinova, Marija; McLuckey, Scott A. (2010). "Mentinova, Marija, and Scott A. McLuckey. "Covalent modification of gaseous peptide ions with N-hydroxysuccinimide ester reagent ions." Journal of the American Chemical Society 132.51 (2010): 18248-18257". Journal of the American Chemical Society. 132 (51): 18248–18257. doi: 10.1021/ja107286p. PMC 3010255. PMID 21128662.
- ^ Sun, Tzu-Lin; Sun, Yen; Lee, Chang-Chun; Huang, Huey W. (2013). "Sun, Tzu-Lin, et al. "Membrane permeability of hydrocarbon-cross-linked peptides." Biophysical Journal 104.9 (2013): 1923-1932". Biophysical Journal. 104 (9): 1923–1932. doi: 10.1016/j.bpj.2013.03.039. PMC 3647159. PMID 23663835.
- ^ Vanderpool, Darin; Johnson, Ted O.; Ping, Chen; Bergqvist, Simon; Alton, Gordon; Phonephaly, Soneprasith; Rui, Eugene; Luo, Chun; Deng, Ya-Li; Grant, Stephan; Quenzer, Terri; Margosiak, Steve; Register, James; Brown, Ed; Ermolieff, Jacques (2009). "Vanderpool, Darin, et al. "Characterization of the CHK1 allosteric inhibitor binding site." Biochemistry 48.41 (2009): 9823-9830". Biochemistry. 48 (41): 9823–9830. doi: 10.1021/bi900258v. PMID 19743875.
- ^ "Ardiani, Andressa, et al. "Vaccine-mediated immunotherapy directed against a transcription factor driving the metastatic process." Cancer research 74.7 (2014): 1945-1957".