Collectin-12, also known as collectin subfamily member 12, is a
collectinprotein that in humans is encoded by the COLEC12gene.[5]
Function
This gene encodes a member of the
collectin family,
proteins that possess
collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with
host defense. It can bind to carbohydrate
antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified
low density lipoprotein by
vascular endothelial cells. [provided by RefSeq, May 2018].
Yoshida T, Tsuruta Y, Iwasaki M, Yamane S, Ochi T, Suzuki R (March 2003). "SRCL/CL-P1 recognizes GalNAc and a carcinoma-associated antigen, Tn antigen". J. Biochem. 133 (3): 271–7.
doi:
10.1093/jb/mvg037.
PMID12761161.
Selman L, Skjodt K, Nielsen O, Floridon C, Holmskov U, Hansen S (June 2008). "Expression and tissue localization of collectin placenta 1 (CL-P1, SRCL) in human tissues". Mol. Immunol. 45 (11): 3278–88.
doi:
10.1016/j.molimm.2008.02.018.
PMID18423602.