From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Charged multivesicular body protein 1a is a
protein that in humans is encoded by the CHMP1A
gene .
[5]
[6]
[7]
Function
This gene encodes a member of the CHMP/Chmp family of proteins which are involved in multivesicular body sorting of proteins to the interiors of lysosomes. The initial prediction of the protein sequence encoded by this gene suggested that the encoded protein was a metallopeptidase. The nomenclature has been updated recently to reflect the correct biological function of this encoded protein.
[7]
Interactions
CHMP1A has been shown to
interact with
VPS4A .
[5]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000131165 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000000743 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (July 2001).
"CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins" . Journal of Cell Science . 114 (Pt 13): 2395–404.
doi :
10.1242/jcs.114.13.2395 .
PMID
11559748 .
^ Stauffer DR, Howard TL, Nyun T, Hollenberg SM (July 2001).
"CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression" . Journal of Cell Science . 114 (Pt 13): 2383–93.
doi :
10.1242/jcs.114.13.2383 .
PMID
11559747 .
^
a
b
"Entrez Gene: PCOLN3 procollagen (type III) N-endopeptidase" .
External links
Further reading
Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, et al. (1995).
"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1" . DNA Research . 1 (5): 223–9.
doi :
10.1093/dnares/1.5.223 .
PMID
7584044 .
Scott IC, Halila R, Jenkins JM, Mehan S, Apostolou S, Winqvist R, et al. (September 1996). "Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1)". Gene . 174 (1): 135–43.
doi :
10.1016/0378-1119(96)00510-0 .
PMID
8863740 .
Yoshida H, Haze K, Yanagi H, Yura T, Mori K (December 1998).
"Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors" . The Journal of Biological Chemistry . 273 (50): 33741–9.
doi :
10.1074/jbc.273.50.33741 .
PMID
9837962 .
Tong WY, Nagano-Fujii M, Hidajat R, Deng L, Takigawa Y, Hotta H (December 2002).
"Physical interaction between hepatitis C virus NS4B protein and CREB-RP/ATF6beta" (PDF) . Biochemical and Biophysical Research Communications . 299 (3): 366–72.
doi :
10.1016/S0006-291X(02)02638-4 .
PMID
12445808 . Archived from
the original (PDF) on 2020-07-12. Retrieved 2020-07-12 .
Strack B, Calistri A, Craig S, Popova E, Göttlinger HG (September 2003).
"AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding" . Cell . 114 (6): 689–99.
doi :
10.1016/S0092-8674(03)00653-6 .
PMID
14505569 .
S2CID
10733770 .
von Schwedler UK, Stuchell M, Müller B, Ward DM, Chung HY, Morita E, et al. (September 2003).
"The protein network of HIV budding" . Cell . 114 (6): 701–13.
doi :
10.1016/S0092-8674(03)00714-1 .
PMID
14505570 .
S2CID
16894972 .
Martin-Serrano J, Yarovoy A, Perez-Caballero D, Bieniasz PD, Yaravoy A (October 2003).
"Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins" . Proceedings of the National Academy of Sciences of the United States of America . 100 (21): 12414–9.
Bibcode :
2003PNAS..10012414M .
doi :
10.1073/pnas.2133846100 .
PMC
218772 .
PMID
14519844 .
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007).
"Large-scale mapping of human protein-protein interactions by mass spectrometry" . Molecular Systems Biology . 3 (1): 89.
doi :
10.1038/msb4100134 .
PMC
1847948 .
PMID
17353931 .
Row PE, Liu H, Hayes S, Welchman R, Charalabous P, Hofmann K, et al. (October 2007).
"The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation" (PDF) . The Journal of Biological Chemistry . 282 (42): 30929–37.
doi :
10.1074/jbc.M704009200 .
PMID
17711858 .
S2CID
28086824 .