Butyrophilin References

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Structures	Swiss-model
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Butyrophilin, subfamily 1, member A1
Butyrophilin, subfamily 1, member A1
Identifiers
Symbol	BTN1A1
NCBI gene	696
HGNC	1135
RefSeq	NP_001723
UniProt	Q13410
Other data
Locus	Chr. 6 p22.2
Structures
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Structures	Swiss-model
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Butyrophilin
Butyrophilin
Identifiers
Symbol	Butyrophilin
Membranome	14

Butyrophilin, subfamily 2, member A2

Identifiers

Symbol

Other data

Chr. 6 p22.2

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Structures	Swiss-model
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Butyrophilin, subfamily 3, member A1

Identifiers

Symbol

Other data

Chr. 6 p22.2

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Structures	Swiss-model
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Butyrophilins are membrane proteins belonging to the immunoglobulin superfamily (Ig).^[1]^[2] Butyrophilin (Btn) genes constitute a subgroup of at least 10 genes in the Ig superfamily identified in human, mouse, cow, goat and other species.^[3]

The eponymous Btn gene (BTN1A1 in humans; Btn1a1 in mouse) is highly expressed in the secretory epithelium of the mammary gland during lactation. Other homologues are predominantly expressed in skeletal muscle and the intestine and erythroid cells. In contrast, BTN2A1 and 2 and BTN3A1, 2, and 3 are widely expressed in many tissues, suggesting that the structural domains of Btn proteins may have both universal and tissue-specific functions.

Types include:

BTN1A1 - Regulates secretion of milk-lipid droplets
BTN2A2 - Involved in lipid, fatty-acid, and sterol metabolism
BTN3A1 - Presents phosphoantigens to Gamma delta T cells

References

^ Mather IH, Jack LJ (1993). "A review of the molecular and cellular biology of butyrophilin, the major protein of bovine milk fat globule membrane". Journal of Dairy Science. 76 (12): 3832–50. doi: 10.3168/jds.S0022-0302(93)77726-7. PMID 8132890.
^ Afrache H, Gouret P, Ainouche S, Pontarotti P, Olive D (2012). "The butyrophilin (BTN) gene family: from milk fat to the regulation of the immune response". Immunogenetics. 64 (11): 781–94. doi: 10.1007/s00251-012-0619-z. PMID 23000944. S2CID 13220808.
^ Ogg SL, Weldon AK, Dobbie L, Smith AJ, Mather IH (2004). "Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets". Proceedings of the National Academy of Sciences of the United States of America. 101 (27): 10084–9. Bibcode: 2004PNAS..10110084O. doi: 10.1073/pnas.0402930101. PMC 454168. PMID 15226505.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[Mather_1993-1] Mather IH, Jack LJ (1993). "A review of the molecular and cellular biology of butyrophilin, the major protein of bovine milk fat globule membrane". Journal of Dairy Science. 76 (12): 3832–50. doi: 10.3168/jds.S0022-0302(93)77726-7. PMID 8132890.

[Afrache_2012-2] Afrache H, Gouret P, Ainouche S, Pontarotti P, Olive D (2012). "The butyrophilin (BTN) gene family: from milk fat to the regulation of the immune response". Immunogenetics. 64 (11): 781–94. doi: 10.1007/s00251-012-0619-z. PMID 23000944. S2CID 13220808.

[pmid15226505-3] Ogg SL, Weldon AK, Dobbie L, Smith AJ, Mather IH (2004). "Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets". Proceedings of the National Academy of Sciences of the United States of America. 101 (27): 10084–9. Bibcode: 2004PNAS..10110084O. doi: 10.1073/pnas.0402930101. PMC 454168. PMID 15226505.

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