Butylphthalide (3-n-butylphthalide or NBP) is one of the chemical constituents in celery oil, along with
sedanolide, which is primarily responsible for the aroma and taste of
celery.[1]
NBP undergoes extensive metabolism in humans.[9] The major metabolites in human plasma were 3-OH-NBP, 10-OH-NBP, 10-CO-NBP, 11-COOH-NBP. The
AUC of metabolites was much larger than that of NBP.
Minor side effects were observed in preclinical and clinical studies. The minor bioactivation pathway of NBP was proved to be mediated via sulfation of 3-OH-NBP.[10]
References
^Wilson, Charles Welthy III (1970). "Relative recovery and identification of carbonyl compounds from celery essential oil". Journal of Food Science. 35 (6): 766–768.
doi:
10.1111/j.1365-2621.1970.tb01989.x.
^Houston, M (2005). "Nutraceuticals, Vitamins, Antioxidants, and Minerals in the Prevention and Treatment of Hypertension". Progress in Cardiovascular Diseases. 47 (6): 396–449.
doi:
10.1016/j.pcad.2005.01.004.
PMID16115519.
^Feng, X; Peng, Y; Liu, M; Cui, L (2011). "Dl-3-n-butylphthalide extends survival by attenuating glial activation in a mouse model of amyotrophic lateral sclerosis". Neuropharmacology. 62 (2): 1004–10.
doi:
10.1016/j.neuropharm.2011.10.009.
PMID22056419.
S2CID37504365.
^Diao X, Deng P, Xie C, Li X, Zhong D, Zhang Y, Chen X. Metabolism and pharmacokinetics of 3-n-butylphthalide (NBP) in humans: the role of cytochrome P450s and alcohol dehydrogenase in biotransformation. Drug Metab Dispos 2013;41:430-444.
^Diao X, Pang X, Xie C, Guo Z, Zhong D, Chen X. Bioactivation of 3-n-butylphthalide via sulfation of its major metabolite 3-hydroxy-NBP: mediated mainly by sulfotransferase 1A1. Drug Metab Dispos 2014;42:774-781.