The genetic structure of Bunyamwera orthobunyavirus is typical for Bunyavirales viruses, which are an order of enveloped
negative-sense, single-strandedRNA viruses with a
genome split into three parts—Small (S), Middle (M), and Large (L). The L RNA segment encodes an RNA-dependent
RNA polymerase (L protein), the M RNA segment encodes two surface
glycoproteins (Gc and Gn) and a
nonstructural protein (NSm), while the S RNA segment encodes a nucleocapsid protein (N) and, in an alternative overlapping
reading frame, a second nonstructural protein (NSs).[7] The genomic RNA segments are encapsidated by copies of the N protein in the form of
ribonucleoprotein (RNP) complexes.[8] The N protein is the most abundant protein in virus particles and infected cells and, therefore, the main target in many serological and molecular diagnostics.[9][10]
In humans, Bunyamwera orthobunyavirus causes Bunyamwera fever.
References
^"ICTV 9th Report (2011) Bunyaviridae"(html). International Committee on Taxonomy of Viruses (ICTV). Retrieved 31 January 2019. Bunya: from Bunyamwera, place in Uganda, where type virus was isolated.
^Bilk, S.; Schulze, C.; Fischer, M.; Beer, M.; Hlinak, A.; Hoffmann, B. (2012-09-14). "Organ distribution of Schmallenberg virus RNA in malformed newborns". Veterinary Microbiology. 159 (1–2): 236–238.
doi:
10.1016/j.vetmic.2012.03.035.
PMID22516190.