From Wikipedia, the free encyclopedia
Comparison H&E stain (left) with BerEP4 immunohistochemistry staining (right) on a pathological section having BCC with squamous cell metaplasia. Only BCC cells are stained with BerEP4. [1]
Comparison H&E stain (left) with BerEP4 immunohistochemistry staining (right) on superficial BCC pathological sections mimicking Bowen’s Disease. [1] At bottom, columnar epithelium in normal sweat glands stain positive too.

BerEp4 (also Ber-EP4) is a histologic stain mainly used to aid in the diagnosis of basal cell carcinoma (BCC). [2] It is an antibody to EpCAM ( epithelial cell adhesion molecule). [1]

Clinical use

BerEp4 has a high sensitivity and specificity in being positive only in BCC cells. [1] BerEp4 is normally negative in squamous epithelium and mesothelium, but otherwise normally positive most epithelial cells of the body. [3] It can also help in distinguishing pulmonary adenocarcinoma (positive BerEp4) from mesothelioma (generally negative BerEp4). [3] [4]

See also

References

  1. ^ a b c d Sunjaya, Anthony Paulo; Sunjaya, Angela Felicia; Tan, Sukmawati Tansil (2017). "The Use of BEREP4 Immunohistochemistry Staining for Detection of Basal Cell Carcinoma". Journal of Skin Cancer. 2017: 1–10. doi: 10.1155/2017/2692604. ISSN  2090-2905. PMC  5804366. PMID  29464122.
  2. ^ "Ber-EP4". e-immunohistochemistry.info. Retrieved 24 May 2017.
  3. ^ a b "Test ID: BEREP - Ber-EP4 (Epithelial Cell Adhesion Molecule/EPCAM) Immunostain, Technical Component Only". Mayo Clinic Laboratories. Retrieved 2019-12-16.
  4. ^ Ordóñez, Nelson G. (1998). "Value of the Ber-EP4 Antibody in Differentiating Epithelial Pleural Mesothelioma From Adenocarcinoma:The M.D. Anderson Experience and a Critical Review of the Literature". American Journal of Clinical Pathology. 109 (1): 85–89. doi: 10.1093/ajcp/109.1.85. ISSN  0002-9173. PMID  9426522.
Retrieved from " https://en.wikipedia.org/?title=BerEp4&oldid=1060504929"