Barbara Illingworth Brown was an American biochemist. She worked primarily at Washington University in St. Louis.

Education and career

Brown was born in Hartford, Connecticut and later moved to Pennsylvania when her father's job in insurance moved the family. ^[2] Brown graduated from Smith College in 1946. She worked with Jane Anne Russell at Yale University ^[2] and received her PhD in physiological chemistry in 1950. ^{[3] [4]} Following her Ph.D., Brown applied to work with the Nobel Prize-winner Gerty Cori ^[2] and became a Research Associate Professor of Biochemistry at Washington University in St. Louis and Established Investigator of the American Heart Association. ^[5] She later also worked with Cori's husband and fellow Nobel Prize winner Carl Ferdinand Cori. ^[2] She retired in 1989. ^[2]

Brown served on the National Advisory General Medical Sciences Council at the National Institutes of Health from 1972 to 1974. ^[6] She was awarded the Wilbur Cross Medal from Yale in 1983. ^[7]

Research

Her work was primarily devoted to the biochemistry of inherited metabolic diseases. ^[1] She investigated the structure of glycogen and amylopectins, ^{[2] [8]} and defined the pathway and mechanisms of phosphorylase enzymes. ^{[9] [10]} Her research included the discovery of enzymes ^[11] in a previously unknown pathway to process glycogen. ^[12] She went on to research diseases related to the storage of glycogen where these enzymes were absent. ^{[13] [14]} She applied some of Carl Cori's findings to medical cases, ^[15] and confirmed the second known case of fructose bisphosphatase deficiency, a rare metabolic disorder, in 1970. ^{[16] [17]} She played a similar role in therapeutic research into glycogen storage disease type I. ^{[18] [19]}

Personal life

Her husband, David H. Brown, was also a scientist and they collaborated on research on polysaccharide synthesis and glycogen storage diseases. ^[2]

Selected publications

• ILLINGWORTH, BARBARA A; RUSSELL, JANE A (1951). "The Effects of Growth Hormone on Glycogen in Tissues of the Rat1". Endocrinology. 48 (4): 423–434. doi: 10.1210/endo-48-4-423. ISSN  0013-7227. OCLC  4631825308. PMID  14831545.
• Illingworth, Barbara; Jansz, Hendrik S.; Brown, David H.; Cori, Carl F. (1958-12-15). "Observations on the Function of Pyridoxal-5-Phosphate in Phosphorylase". Proceedings of the National Academy of Sciences. 44 (12): 1180–1191. Bibcode: 1958PNAS...44.1180I. doi: 10.1073/pnas.44.12.1180. ISSN  0027-8424. PMC  528705. PMID  16590330.
• Illingworth, Barbara; Brown, David H.; Cori, Carl F. (1961-04-01). "The De Novo Synthesis of Polysaccharide by Phosphorylase". Proceedings of the National Academy of Sciences. 47 (4): 469–478. Bibcode: 1961PNAS...47..469I. doi: 10.1073/pnas.47.4.469. ISSN  0027-8424. PMC  221475. PMID  13717528.
• Eberlein, Walter R; Illingworth, Barbara A; Sidbury, James B (1962). "Heterogeneous glycogen storage disease in siblings and favorable response to synthetic androgen administration". AJM the American Journal of Medicine. 33 (1): 20–26. doi: 10.1016/0002-9343(62)90273-5. ISSN  0002-9343. OCLC  4922525423. PMID  13889017.
• Brown, Barbara Illingworth; Brown, David H (1966). "Lack of an α -1,4-Glucan: α -1,4-Glucan 6-glycosyl Transferase in a Case of Type IV Glycogenosis". Proceedings of the National Academy of Sciences of the United States of America. 56 (2): 725–729. Bibcode: 1966PNAS...56..725B. doi: 10.1073/pnas.56.2.725. ISSN  0027-8424. OCLC  5554094258. PMC  224432. PMID  5229990.

References