Ezem ( Hebrew: עצם, vars. ‛Atsem, 'Asam, Azem, 'Osem or Otzem, meaning strength, might, bone, to close, to defend, [1] also self, [2] self-same [3] and strenuous [4]) is an unidentified site in the Negev of Judah toward the Edomite border.
It is mentioned in the Biblical Book of Joshua ( 15:29; 19:1–3). In the King James Version it is spelled "Azem" in Joshua and "Ezem" in Chronicles ( 4:29).
In Joshua 19:1-3 and 1 Chronicles 4:29 it is one of the towns "in the midst of the inheritance of Judah" assigned to Simeon. [5]