Apoptozole is a drug that acts as a potent and selective inhibitor of the
heat shock proteinHsp70, and was one of the first compounds developed to act at this target. It induces
apoptosis in susceptible cells, and displays anti-
cancer, anti-
malarial and
antiviral activity. The promising results in animal studies makes it likely that either apoptozole or compounds with similar modes of action will be further researched as potential therapeutics in the future.[1][2][3][4][5]
References
^Ko SK, Kim J, Na DC, Park S, Park SH, Hyun JY, et al. (March 2015). "A small molecule inhibitor of ATPase activity of HSP70 induces apoptosis and has antitumor activities". Chemistry & Biology. 22 (3): 391–403.
doi:
10.1016/j.chembiol.2015.02.004.
PMID25772468.
^Yang J, Xu Y, Yan Y, Li W, Zhao L, Dai Q, et al. (February 2020). "Small Molecule Inhibitor of ATPase Activity of HSP70 as a Broad-Spectrum Inhibitor against Flavivirus Infections". ACS Infectious Diseases. 6 (5): 832–843.
doi:
10.1021/acsinfecdis.9b00376.
PMID31967789.