Ruffini was a pioneer in the study of
amphibiangastrulation, providing a comprehensive and detailed description on the formation of "bottle cells". He published these findings in a book titled Fisiogenia (1925).
Relationship with Sir Charles Sherrington
Between 1896 and 1903, Ruffini corresponded regularly with
Sir Charles Sherrington.[3] This relationship evolved after Ruffini sent copies of his papers on muscle nerve endings[4][5] to Sherrington. Ruffini also sent Sherrington eleven slides of
'Organi nervosi' (
available online) and Sherrington was instrumental in getting Ruffini's work published in the Journal of Physiology.[6][7]
[2] Amphibian gastrulation: history and evolution of a 125-year-old concept
^[1] The Book of Lists By David Wallechinsky, et al
^Molnár Z, Brown RE., 2010. Insights into the life and work of Sir Charles Sherrington. Nat Rev Neurosci. 11(6):429-36
^Eccles, J. C., 1975. Letters from C. S. Sherrington, F. R. S., to Angelo Ruffini between 1896 and 1903. Notes Rec. R. Soc. 30, 69–82
^Ruffini, A., 1892 Di una particolare reticella nervosa e di alcuni corpuscoli del Pacini che si trovano in connessione cogli organi muscolo-tendinei del gatto. Nota preventiva. Atti dell' Accademia nazionale dei Lincei. Rendiconti. Classe di scienze fisiche, matematiche e naturali, 5th ser., vol. 7 no. 1, 442–446
^Ruffini, A., 1896. Sulla fine anatomia dei fusi neuro-muscuolare del gatto e sul loro significato fisiologico. Monitore Zoologico Italiano 7, 49–52.
^Ruffini, A., 1898. On the minute anatomy of the neuromuscular spindles of the cat, and on their physiological significance. J. Physiol. 23, 191–208
^Molnár Z, Brown RE., 2010. Insights into the life and work of Sir Charles Sherrington. Nat Rev Neurosci. 11(6):429-36