Bodily responses to the functional effects of ethanol in alcoholic beverages
Alcohol tolerance refers to the bodily responses to the functional effects of
ethanol in alcoholic beverages. This includes direct tolerance, speed of recovery from insobriety and resistance to the development of
alcohol use disorder.
Consumption-induced tolerance
Alcohol tolerance is increased by regular drinking.[1] This reduced sensitivity to the physical effects of
alcohol consumption requires that higher quantities of alcohol be consumed in order to achieve the same
effects as before tolerance was established. Alcohol tolerance may lead to (or be a sign of) alcohol dependence.[1]
Heavy alcohol consumption over a period of years can lead to "reverse tolerance". A liver can be damaged by chronic alcohol use, leading to a buildup of fat and scar tissue.[2] The reduced ability of such a liver to
metabolize or break down alcohol means that small amounts can lead to a high
blood alcohol concentration (BAC) and more rapid
intoxication.[citation needed] Studies have shown that 2–3 weeks of daily alcohol consumption increases tolerance.[3]
Physiology of alcohol tolerance
Direct alcohol tolerance is largely dependent on body size. Large-bodied people will require more alcohol to reach insobriety than lightly built people.[4] Thus, men, being larger than women on average, will typically have a higher alcohol tolerance. The alcohol tolerance is also connected with activity of alcohol dehydrogenases (a group of
enzymes responsible for the breakdown of alcohol) in the
liver, and in the bloodstream.
High level of alcohol dehydrogenase activity results in fast transformation of ethanol to more toxic
acetaldehyde. Such atypical alcohol dehydrogenase levels are less frequent in alcoholics than in non-alcoholics.[5] Furthermore, among alcoholics, the carriers of this atypical enzyme consume lower ethanol doses, compared to the individuals without the
allele.[citation needed]
An estimated one out of twenty people have an
alcohol flush reaction. It is not in any way an indicator for the drunkenness of an individual.[6][7] A mild flushing reaction occurs when the body metabolizes alcohol more quickly into acetaldehyde, a toxic metabolite.[5][8] A more severe flushing reaction occurs when the body metabolizes the acetaldehyde more slowly, generally due to an inactive aldehyde dehydrogenase enzyme. Both of those conditions—faster conversion of alcohol to acetaldehyde and slower removal of acetaldehyde—reduce the risk for excessive drinking and alcohol dependence.[5]
To engage in alcohol consumption and the development of an alcohol use disorder appear to be common to
primates, and is not a specific human phenomenon.[9] Humans have access to alcohol in far greater quantity than non-human primates, and the availability increased, particularly with the development of agriculture.[10] The tolerance to alcohol is not equally distributed throughout the world's population.[11] Genetics of
alcohol dehydrogenase indicate resistance has arisen independently in different cultures.[12] In North America, Native Americans have the highest probability of developing an
alcohol use disorder compared to Europeans and Asians.[13][14][15][16] Different alcohol tolerance also exists within Asian groups, such as between Chinese and Koreans.[17] The health benefits of a modest alcohol consumption reported in people of European descent appear not to exist among people of African descent.[18]
Higher body masses and the prevalence of high levels of alcohol dehydrogenase in an individual increase alcohol tolerance, and both adult weight and enzymes vary with ethnicity.[19][20] Not all differences in tolerance can be traced to biochemistry, however.[21] Differences in tolerance levels are also influenced by socio-economic and cultural difference including diet, average body weight and patterns of consumption.[22][23]
Footnotes
^
ab"Alcohol and Tolerance". National Institute on Alcohol Abuse and Alcoholism (NIAAA), Alcohol Alert (28). April 1995. Retrieved 2009-08-13.
^Yin, S. -J.; Cheng, T. -C.; Chang, C. -P.; Chen, Y. -J.; Chao, Y. -C.; Tang, H. -S.; Chang, T. -M.; Wu, C. -W. (1988). "Human stomach alcohol and aldehyde dehydrogenases (ALDH): A genetic model proposed for ALDH III isozymes". Biochemical Genetics. 26 (5–6): 343–60.
doi:
10.1007/BF00554070.
PMID3214414.
S2CID9315241.
^Bennion L.; Li T. K. (1976). "Alcohol metabolism in American Indians and whites". New England Journal of Medicine. 294 (1): 9–13.
doi:
10.1056/nejm197601012940103.
PMID1244489.
^Saggers, S. & Gray, D. (1998b). Dealing with Alcohol: Indigenous Usage in Australia, New Zealand and Canada. Cambridge: Cambridge University Press[page needed]
References
Carroll, Charles R. Drugs in Modern Society . NY: McGraw-Hill, 2000 (fifth ed.).
Chesher, G.; Greeley, J. (1992). "Tolerance to the effects of alcohol". Alcohol, Drugs and Driving. 8 (2): 93–106.
Muramatsu, T; Wang, ZC; Fang, YR; Hu, KB; Yan, H; Yamada, K; Higuchi, S; Harada, S; Kono, H (1995). "Alcohol and aldehyde dehydrogenase genotypes and drinking behavior of Chinese living in Shanghai". Human Genetics. 96 (2): 151–4.
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Neumark, YD; Friedlander, Y; Thomasson, HR; Li, TK (1998). "Association of the ADH2*2 allele with reduced ethanol consumption in Jewish men in Israel: A pilot study". Journal of Studies on Alcohol. 59 (2): 133–9.
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Borinskaya, S. A.; Gasemianrodsari, F.; Kalyina, N. R.; Sokolova, M. V.; Yankovsky, N. K. (2005). "Polymorphism of Alcohol Dehydrogenase Gene ADH1B in Eastern Slavic and Iranian-Speaking Populations". Russian Journal of Genetics. 41 (11): 1291–4.
doi:
10.1007/s11177-005-0231-5.
S2CID4686166. Translated from "Polymorphism of alcohol dehydrogenase gene ADH1B in eastern Slavic and Iranian-speaking populations". Genetika. 41 (11): 1563–6. 2005.
PMID16358724.