From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
ATP6AP2 Identifiers
Aliases
ATP6AP2 , APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS, HT028, ATPase H+ transporting accessory protein 2, CDG2RExternal IDs
OMIM :
300556
MGI :
1917745
HomoloGene :
38097
GeneCards :
ATP6AP2
Wikidata
The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2 , or the prorenin receptor , is a
protein that in humans is encoded by the ATP6AP2
gene .
[5]
[6]
[7]
Function
The renin receptor binds
renin and
prorenin . Binding of renin to this receptor induces the conversion of
angiotensinogen to
angiotensin I .
[8]
This protein is associated with adenosine triphosphatases (
ATPases ). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000182220 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000031007 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H (Jun 1998).
"Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules" . J Biol Chem . 273 (18): 10939–47.
doi :
10.1074/jbc.273.18.10939 .
PMID
9556572 .
^ Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB (Oct 2001). "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)". Mol Vis . 7 : 234–9.
PMID
11590366 .
^
a
b
"Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2" .
^ Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD (June 2002).
"Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin" . J. Clin. Invest . 109 (11): 1417–27.
doi :
10.1172/JCI14276 .
PMC
150992 .
PMID
12045255 .
Further reading
Kaneshiro Y, Ichihara A, Sakoda M, et al. (2007).
"Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats" (PDF) . J. Am. Soc. Nephrol . 18 (6): 1789–95.
doi :
10.1681/ASN.2006091062 .
PMID
17494887 .
Schefe JH, Menk M, Reinemund J, et al. (2007).
"A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein" . Circ. Res . 99 (12): 1355–66.
CiteSeerX
10.1.1.486.8053 .
doi :
10.1161/01.RES.0000251700.00994.0d .
PMID
17082479 .
Kaneshiro Y, Ichihara A, Takemitsu T, et al. (2006).
"Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats" . Kidney Int . 70 (4): 641–6.
doi :
10.1038/sj.ki.5001627 .
PMID
16807542 .
Burcklé CA, Jan Danser AH, Müller DN, et al. (2006).
"Elevated blood pressure and heart rate in human renin receptor transgenic rats" . Hypertension . 47 (3): 552–6.
doi :
10.1161/01.HYP.0000199912.47657.04 .
PMID
16401765 .
Huang Y, Wongamorntham S, Kasting J, et al. (2006).
"Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms" . Kidney Int . 69 (1): 105–13.
doi :
10.1038/sj.ki.5000011 .
PMID
16374430 .
Otsuki T, Ota T, Nishikawa T, et al. (2007).
"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries" . DNA Res . 12 (2): 117–26.
doi :
10.1093/dnares/12.2.117 .
PMID
16303743 .
Ramser J, Abidi FE, Burckle CA, et al. (2005). "A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor". Hum. Mol. Genet . 14 (8): 1019–27.
doi :
10.1093/hmg/ddi094 .
PMID
15746149 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Hedera P, Alvarado D, Beydoun A, Fink JK (2002). "Novel mental retardation-epilepsy syndrome linked to Xp21.1-p11.4". Ann. Neurol . 51 (1): 45–50.
doi :
10.1002/ana.10051 .
hdl :
2027.42/34887 .
PMID
11782983 .
S2CID
18107509 .
Hu RM, Han ZG, Song HD, et al. (2000).
"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning" . Proc. Natl. Acad. Sci. U.S.A . 97 (17): 9543–8.
Bibcode :
2000PNAS...97.9543H .
doi :
10.1073/pnas.160270997 .
PMC
16901 .
PMID
10931946 .
External links