From Wikipedia, the free encyclopedia
Protein-coding gene in humans
ATP11C is an
enzyme that in humans is encoded by the ATP11C
gene .
Function
ATP11C encodes a member of the Type IV
P-type ATPase family that is thought to transport or 'flip' aminophospholipids. The corresponding protein in mice is essential for the development of
B cells and
red blood cells ,
[5]
[6] and for the prevention of intrahepatic
cholestasis .
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000101974 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000062949 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, Nemazee D, Beutler B (May 2011).
"The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow" . Nature Immunology . 12 (5): 434–40.
doi :
10.1038/ni.2012 .
PMC
3079768 .
PMID
21423172 .
^ Yabas M, Teh CE, Frankenreiter S, Lal D, Roots CM, Whittle B, Andrews DT, Zhang Y, Teoh NC, Sprent J, Tze LE, Kucharska EM, Kofler J, Farell GC, Bröer S, Goodnow CC, Enders A (May 2011).
"ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes" . Nature Immunology . 12 (5): 441–9.
doi :
10.1038/ni.2011 .
PMC
3272780 .
PMID
21423173 .
^ Siggs OM, Schnabl B, Webb B, Beutler B (May 2011).
"X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C" . Proceedings of the National Academy of Sciences of the United States of America . 108 (19): 7890–5.
Bibcode :
2011PNAS..108.7890S .
doi :
10.1073/pnas.1104631108 .
PMC
3093471 .
PMID
21518881 .