From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a
protein that in humans is encoded by the ARFGEF1
gene .
[5]
[6]
[7]
Function
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.
[7]
Interactions
ARFGEF1 has been shown to
interact with
FKBP2 ,
[8]
ARFGEF2
[9] and
PRKAR1A .
[10]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000066777 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000067851 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M (Apr 1999).
"Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors" . The Journal of Biological Chemistry . 274 (18): 12308–15.
doi :
10.1074/jbc.274.18.12308 .
PMID
10212200 .
^ Morinaga N, Tsai SC, Moss J, Vaughan M (Nov 1996).
"Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain" . Proceedings of the National Academy of Sciences of the United States of America . 93 (23): 12856–60.
Bibcode :
1996PNAS...9312856M .
doi :
10.1073/pnas.93.23.12856 .
PMC
24010 .
PMID
8917509 .
^
a
b
"Entrez Gene: ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)" .
^ Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M (Mar 2003).
"Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506" . Proceedings of the National Academy of Sciences of the United States of America . 100 (5): 2322–7.
Bibcode :
2003PNAS..100.2322P .
doi :
10.1073/pnas.2628047100 .
PMC
151339 .
PMID
12606707 .
^ Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000).
"Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex" . Proceedings of the National Academy of Sciences of the United States of America . 97 (6): 2567–72.
Bibcode :
2000PNAS...97.2567Y .
doi :
10.1073/pnas.97.6.2567 .
PMC
15969 .
PMID
10716990 .
^ Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003).
"Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)" . Proceedings of the National Academy of Sciences of the United States of America . 100 (4): 1627–32.
Bibcode :
2003PNAS..100.1627L .
doi :
10.1073/pnas.0337678100 .
PMC
149883 .
PMID
12571360 .
External links
Further reading
Bonaldo MF, Lennon G, Soares MB (1997).
"Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Research . 6 (9): 791–806.
doi :
10.1101/gr.6.9.791 .
PMID
8889548 .
Mansour SJ, Skaug J, Zhao XH, Giordano J, Scherer SW, Melançon P (Jul 1999).
"p200 ARF-GEP1: a Golgi-localized guanine nucleotide exchange protein whose Sec7 domain is targeted by the drug brefeldin A" . Proceedings of the National Academy of Sciences of the United States of America . 96 (14): 7968–73.
Bibcode :
1999PNAS...96.7968M .
doi :
10.1073/pnas.96.14.7968 .
PMC
22171 .
PMID
10393931 .
Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000).
"Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex" . Proceedings of the National Academy of Sciences of the United States of America . 97 (6): 2567–72.
Bibcode :
2000PNAS...97.2567Y .
doi :
10.1073/pnas.97.6.2567 .
PMC
15969 .
PMID
10716990 .
Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K (Oct 2000). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members". Genomics . 69 (1): 113–9.
doi :
10.1006/geno.2000.6310 .
PMID
11013081 .
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (Jan 2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nature Genetics . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M (Mar 2004).
"Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors" . Proceedings of the National Academy of Sciences of the United States of America . 101 (9): 2752–7.
Bibcode :
2004PNAS..101.2752P .
doi :
10.1073/pnas.0307345101 .
PMC
365693 .
PMID
14973189 .
Saeki N, Tokuo H, Ikebe M (Mar 2005).
"BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity" . The Journal of Biological Chemistry . 280 (11): 10128–34.
doi :
10.1074/jbc.M413415200 .
PMID
15644318 .
Citterio C, Jones HD, Pacheco-Rodriguez G, Islam A, Moss J, Vaughan M (Feb 2006).
"Effect of protein kinase A on accumulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) in HepG2 cell nuclei" . Proceedings of the National Academy of Sciences of the United States of America . 103 (8): 2683–8.
Bibcode :
2006PNAS..103.2683C .
doi :
10.1073/pnas.0510571103 .
PMC
1413798 .
PMID
16467138 .
Belov GA, Altan-Bonnet N, Kovtunovych G, Jackson CL, Lippincott-Schwartz J, Ehrenfeld E (Jan 2007).
"Hijacking components of the cellular secretory pathway for replication of poliovirus RNA" . Journal of Virology . 81 (2): 558–67.
doi :
10.1128/JVI.01820-06 .
PMC
1797456 .
PMID
17079330 .
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48.
doi :
10.1016/j.cell.2006.09.026 .
PMID
17081983 .
S2CID
7827573 .
Shen X, Hong MS, Moss J, Vaughan M (Jan 2007).
"BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein, is required for correct glycosylation and function of integrin beta1" . Proceedings of the National Academy of Sciences of the United States of America . 104 (4): 1230–5.
Bibcode :
2007PNAS..104.1230S .
doi :
10.1073/pnas.0610535104 .
PMC
1783117 .
PMID
17227842 .
Kuroda F, Moss J, Vaughan M (Feb 2007).
"Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma" . Proceedings of the National Academy of Sciences of the United States of America . 104 (9): 3201–6.
Bibcode :
2007PNAS..104.3201K .
doi :
10.1073/pnas.0611696104 .
PMC
1805514 .
PMID
17360629 .