From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
A-kinase anchor protein 5 is a
protein that in humans is encoded by the AKAP5
gene .
[5]
[6]
[7]
Function
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of
protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene is intronless and encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to
protein kinase C and the phosphatase
calcineurin . It is predominantly expressed in
cerebral cortex and may anchor the PKA protein at
postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in
T lymphocytes and may function to inhibit
interleukin 2 transcription by disrupting calcineurin-dependent dephosphorylation of
NFAT .
[7]
Interactions
AKAP5 has been shown to
interact with:
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000179841 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000021057 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Carr DW, Stofko-Hahn RE, Fraser ID, Cone RD, Scott JD (Sep 1992).
"Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79" . J Biol Chem . 267 (24): 16816–23.
doi :
10.1016/S0021-9258(18)41856-X .
PMID
1512224 .
^ Carr DW, Hausken ZE, Fraser ID, Stofko-Hahn RE, Scott JD (Aug 1992).
"Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain" . J Biol Chem . 267 (19): 13376–82.
doi :
10.1016/S0021-9258(18)42221-1 .
PMID
1618839 .
^
a
b
"Entrez Gene: AKAP5 A kinase (PRKA) anchor protein 5" .
^ Kashishian A, Howard M, Loh C, Gallatin WM, Hoekstra MF, Lai Y (Oct 1998).
"AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region" . J. Biol. Chem . 273 (42): 27412–9.
doi :
10.1074/jbc.273.42.27412 .
PMID
9765270 .
^ Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ (Jan 2003). "A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor beta subunits". Mol. Cell. Neurosci . 22 (1): 87–97.
doi :
10.1016/s1044-7431(02)00017-9 .
PMID
12595241 .
S2CID
6172436 .
External links
Further reading
Lester LB, Scott JD (1997). "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res . 52 : 409–29, discussion 429–30.
PMID
9238861 .
Michel JJ, Scott JD (2002). "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol . 42 : 235–57.
doi :
10.1146/annurev.pharmtox.42.083101.135801 .
PMID
11807172 .
Hirsch AH, Glantz SB, Li Y, et al. (1992).
"Cloning and expression of an intron-less gene for AKAP 75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase II beta" . J. Biol. Chem . 267 (4): 2131–4.
doi :
10.1016/S0021-9258(18)45852-8 .
PMID
1733921 .
Carr DW, Stofko-Hahn RE, Fraser ID, et al. (1991).
"Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif" . J. Biol. Chem . 266 (22): 14188–92.
doi :
10.1016/S0021-9258(18)98665-5 .
PMID
1860836 .
Coghlan VM, Perrino BA, Howard M, et al. (1995). "Association of protein kinase A and protein phosphatase 2B with a common anchoring protein". Science . 267 (5194): 108–11.
Bibcode :
1995Sci...267..108C .
doi :
10.1126/science.7528941 .
PMID
7528941 .
Glantz SB, Li Y, Rubin CS (1993).
"Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase II beta to the cytoskeleton" . J. Biol. Chem . 268 (17): 12796–804.
doi :
10.1016/S0021-9258(18)31458-3 .
PMID
8509414 .
Faux MC, Scott JD (1997).
"Regulation of the AKAP79-protein kinase C interaction by Ca2+/Calmodulin" . J. Biol. Chem . 272 (27): 17038–44.
doi :
10.1074/jbc.272.27.17038 .
PMID
9202019 .
Kashishian A, Howard M, Loh C, et al. (1998).
"AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region" . J. Biol. Chem . 273 (42): 27412–9.
doi :
10.1074/jbc.273.42.27412 .
PMID
9765270 .
Paolillo M, Feliciello A, Porcellini A, et al. (1999).
"The type and the localization of cAMP-dependent protein kinase regulate transmission of cAMP signals to the nucleus in cortical and cerebellar granule cells" . J. Biol. Chem . 274 (10): 6546–52.
doi :
10.1074/jbc.274.10.6546 .
PMID
10037748 .
Dodge KL, Carr DW, Sanborn BM (1999).
"Protein kinase A anchoring to the myometrial plasma membrane is required for cyclic adenosine 3',5'-monophosphate regulation of phosphatidylinositide turnover" . Endocrinology . 140 (11): 5165–70.
doi :
10.1210/endo.140.11.7133 .
PMID
10537145 .
Fraser ID, Cong M, Kim J, et al. (2000).
"Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling" . Curr. Biol . 10 (7): 409–12.
doi :
10.1016/S0960-9822(00)00419-X .
PMID
10753752 .
Sík A, Gulácsi A, Lai Y, et al. (2000). "Localization of the A kinase anchoring protein AKAP79 in the human hippocampus". Eur. J. Neurosci . 12 (4): 1155–64.
doi :
10.1046/j.1460-9568.2000.00002.x .
PMID
10762347 .
S2CID
40933732 .
Colledge M, Dean RA, Scott GK, et al. (2000).
"Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex" . Neuron . 27 (1): 107–19.
doi :
10.1016/S0896-6273(00)00013-1 .
PMID
10939335 .
Indolfi C, Stabile E, Coppola C, et al. (2001).
"Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals" . Circ. Res . 88 (3): 319–24.
doi :
10.1161/01.res.88.3.319 .
PMID
11179200 .
Dart C, Leyland ML (2001).
"Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1" . J. Biol. Chem . 276 (23): 20499–505.
doi :
10.1074/jbc.M101425200 .
PMID
11287423 .
Xie G, Raufman JP (2001).
"Association of protein kinase A with AKAP150 facilitates pepsinogen secretion from gastric chief cells" . Am. J. Physiol. Gastrointest. Liver Physiol . 281 (4): G1051–8.
doi :
10.1152/ajpgi.2001.281.4.G1051 .
PMID
11557526 .
S2CID
20939022 .