Long-chain-fatty-acid—CoA ligase 5 is an
enzyme that in
humans is encoded by the ACSL5gene.[5][6]
The protein encoded by this gene is an
isozyme of the long-chain
fatty-acid-
coenzyme A
ligase family. Although differing in
substrate specificity,
subcellular localization, and
tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty
acyl-
CoAesters, and thereby play a key role in
lipidbiosynthesis and fatty acid degradation. This isozyme is highly expressed in
uterus and
spleen, and in trace amounts in normal
brain, but has markedly increased levels in
malignantgliomas. This gene functions in mediating fatty acid-induced glioma
cell growth. Three transcript variants encoding two different
isoforms have been found for this gene.[6]
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Minekura H, Kang MJ, Inagaki Y, et al. (2002). "Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene". Gene. 278 (1–2): 185–92.
doi:
10.1016/S0378-1119(01)00714-4.
PMID11707336.
Lewin TM, Van Horn CG, Krisans SK, Coleman RA (2002). "Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein located in two distinct subcellular organelles, peroxisomes, and mitochondrial-associated membrane". Arch. Biochem. Biophys. 404 (2): 263–70.
doi:
10.1016/S0003-9861(02)00247-3.
PMID12147264.
Gassler N, Schneider A, Kopitz J, et al. (2003). "Impaired expression of acyl-CoA-synthetase 5 in epithelial tumors of the small intestine". Hum. Pathol. 34 (10): 1048–52.
doi:
10.1053/S0046-8177(03)00431-3.
PMID14608540.
Gassler N, Obermüller N, Keith M, et al. (2005). "Characterization of metaplastic and heterotopic epithelia in the human gastrointestinal tract by the expression pattern of acyl-CoA synthetase 5". Histol. Histopathol. 20 (2): 409–14.
PMID15736044.
Obermüller N, Keith M, Kopitz J, et al. (2006). "Coeliac disease is associated with impaired expression of acyl-CoA-synthetase 5". International Journal of Colorectal Disease. 21 (2): 130–4.
doi:
10.1007/s00384-004-0738-6.
PMID15809837.
S2CID24263574.
Achouri Y, Hegarty BD, Allanic D, et al. (2006). "Long chain fatty acyl-CoA synthetase 5 expression is induced by insulin and glucose: involvement of sterol regulatory element-binding protein-1c". Biochimie. 87 (12): 1149–55.
doi:
10.1016/j.biochi.2005.04.015.
PMID16198472.