From Wikipedia, the free encyclopedia
Thiouric acid
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Names
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IUPAC name
6-Thioxo-7,9-dihydro-1H-purine-2,8(3H,6H)-dione
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Other names
6-Thiouric acid
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Identifiers
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ChEBI
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ChemSpider
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KEGG
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UNII
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InChI=1S/C5H4N4O2S/c10-4-6-1-2(7-4)8-5(11)9-3(1)12/h(H4,6,7,8,9,10,11,12) Key: SXHQUGJSTGOXMD-UHFFFAOYSA-N
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c12c([nH]c(=O)[nH]1)[nH]c(=O)[nH]c2=S
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Properties
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C5H4N4O2S
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Molar mass
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184.17 g·mol−1
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Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Thiouric acid, more accurately called 6-thiouric acid, is a main inactive
metabolite of the
immunosuppressive drugs
azathioprine,
mercaptopurine and
tioguanine.
[1]
[2]
References
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^ Mutschler, Ernst; Schäfer-Korting, Monika (2001). Arzneimittelwirkungen (in German) (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. pp. 107, 936.
ISBN
3-8047-1763-2.
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^ Ansari, A; Aslam, Z; De Sica, A; Smith, M; Gilshenan, K; Fairbanks, L; Marinaki, A; Sanderson, J; Duley, J (2008).
"Influence of xanthine oxidase on thiopurine metabolism in Crohn's disease". Alimentary Pharmacology & Therapeutics. 28 (6): 749–57.
doi:
10.1111/j.1365-2036.2008.03768.x.
PMID
18557988.
S2CID
45417169.