Notes: Values are mean ± SD or range.
ER
RBA =
Relative binding affinity to
estrogen receptors of rat
uterinecytosol. Uterine weight = Percentage change in uterine wet weight of
ovariectomized rats after 72 hours with continuous administration of 1 μg/hour via
subcutaneously implantedosmotic pumps.
LH levels =
Luteinizing hormone levels relative to baseline of ovariectomized rats after 24 to 72 hours of continuous administration via subcutaneous implant. Footnotes:a =
Synthetic (i.e., not
endogenous). b = Atypical uterotrophic effect which plateaus within 48 hours (estradiol's uterotrophy continues linearly up to 72 hours). Sources: See template.
^Longcope C, Rafkind I, Arunachalam T, Caspi E (September 1983). "Biological activities of 4-fluoro estrogen analogues". Journal of Steroid Biochemistry. 19 (3): 1325–1328.
doi:
10.1016/0022-4731(83)90158-9.
PMID6621038.
^Eakins MN, Palmer AJ, Waters SL (November 1979). "Studies in the rat with 18F-4-fluoro-oestradiol and 18F-4-fluoro-oestrone as potential prostate scanning agents: comparison with 125I-2-iodo-oestradiol and 125I-2,4-di-iodo-oestradiol". The International Journal of Applied Radiation and Isotopes. 30 (11): 695–700.
doi:
10.1016/0020-708x(79)90111-x.
PMID544526.
^Al Jasem Y, Thiemann T, Gano L, Oliveira MC (2016). "Fluorinated steroids and their derivatives". Journal of Fluorine Chemistry. 185: 48–85.
doi:
10.1016/j.jfluchem.2016.03.009.
ISSN0022-1139.