The 1980–81 European Cup was the 21st edition of Europe's premier club handball tournament.

Knockout stage

Round 1

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
SC Magdeburg	65–39	ASKÖ Linz	35–18	30–21
VfL Gummersbach	42–29	NCR/Blauw-Wit Neerbeek	25–13	17–16
HB Dudelange	34–37	Sporting Neerpelt	24–16	10–21
Kristiansand IF	35–42	Lugi HF	18–18	17–24
VIF Vestmanna	54–45	Brentwood'72 HC	30–23	24–22
Bányász Tatabánya	90–44	Beşiktaş İstanbul	49–16	41–28
BSV Bern	46–33	Sporting CP	26–12	20–21
Volani Rovereto	W.O.	Stella Sports St. Maur
Hutnik Kraków	48–52	CSKA Moscow	26–26	22–26
BK46 Karis	30–62	KFUM Aarhus	18–25	12–37
Steaua București	62–27	Maccabi Petah Tikva	34–17	28–10
RD Slovan	48–36	VIF G. Dimitrov Sofia	30–16	18–20

Round 2

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
SC Magdeburg	35–28	VfL Gummersbach	19–12	16–16
Dukla Prague	49–30	Sporting Neerpelt	29–16	20–14
Lugi HF	69–40	VIF Vestmanna	30–19	39–21
Víkingur Reykjavík	43–43	Bányász Tatabánya	21–20	22–23
TV Großwallstadt	43–30	BSV Bern	22–9	21–21
Stella Sports St. Maur	39–53	CSKA Moscow	19–24	20–29
FC Barcelona	44–34	KFUM Aarhus	26–16	18–18
Steaua București	39–40	RD Slovan	20–18	19–22

Quarterfinals

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
Dukla Prague	37–42	SC Magdeburg	17–19	20–23
Víkingur Reykjavík	33–34	Lugi HF	16–17	17–17
CSKA Moscow	45–35	TV Großwallstadt	21–15	24–20
FC Barcelona	38–52	RD Slovan	20–21	18–31

Semifinals

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
SC Magdeburg	46–38	Lugi HF	20–18	26–20
CSKA Moscow	47–50	RD Slovan	25–21	22–29

Finals

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
SC Magdeburg	52–43	RD Slovan	23–25	29–18

External links

• EHF Champions League website
• European Cup 1981 edition