The 1968 United States Senate election in Ohio took place on November 5, 1968. Incumbent Senator
Frank Lausche ran for re-election to a third term, but lost the Democratic primary to former U.S. Representative
John J. Gilligan. Before losing the primary to the more solidly liberal Gilligan, Lausche had one of the most conservative voting record among Senate Democrats, leaving the Democratic Party very disappointed. In the general election, Gilligan lost to Republican Ohio Attorney General
William Saxbe in a close race. Saxbe's victory increased the number of Senate Republicans in the
91st Congress. He would serve 5 years in the Senate before being nominated by
President Richard Nixon to be
U.S Attorney General, he resigned the seat after being confirmed. Gilligan, who in January 1974 was serving as the
Governor of Ohio, named Saxbe's successor.