The 1926 United States Senate special election in Missouri took place on November 2, 1926 in
Missouri. The
Republican Senator elected in
1920,
Selden P. Spencer, died on May 16, 1925.
George Howard Williams was appointed to continue Spencer's term on May 25, and ran in this special election to complete the term. He was defeated by the
Democratic nominee
Harry B. Hawes, who won 52% of the vote. Hawes also defeated Williams in the
regular election held the same day.