The 1922 Iowa State Cyclones football team represented Iowa State College of Agricultural and Mechanic Arts—now known as
Iowa State University—during the
1922 college football season. The Cyclones were coached by
Sam Willaman and played their home games at
State Field in
Ames, Iowa. The Cyclones first game was a loss to Coe and their last game was a 54–6 loss to the Nebraska Cornhuskers in Lincoln. The Cyclones finished with a record of 2–6.[1][2]