Pentagalloyl glucose can undergo oxidation reactions which are depending on the pH.[10]
Research
Pentagalloyl glucose has been studied for its potential use as an
antimicrobial,
anti-inflammatory,
anticarcinogenic,
antidiabetic, and
antioxidant.[11] It has also been studied for radioprotection.[5] This compound helps stabilize the elastin and collagen in vascular tissues[12] and restores the biomechanical properties of arterial ECM.[13] In addition, pentagalloyl glucose has shown to reduce arterial calcification and helps promote extracellular matrix preservation in animal models of abdominal aortic aneurysm.[14]In vitro studies with mouse C2C12 myoblast cells have shown the PGG helps in lowering reactive oxygen species (ROS) and matrix metalloproteinase-2 (MMP-2) expression in a dose-dependent manner. [15]
References
^Cammann J, Denzel K, Schilling G, Gross GG (August 1989). "Biosynthesis of gallotannins: beta-glucogallin-dependent formation of 1,2,3,4,6-pentagalloylglucose by enzymatic galloylation of 1,2,3,6-tetragalloylglucose". Archives of Biochemistry and Biophysics. 273 (1): 58–63.
doi:
10.1016/0003-9861(89)90161-6.
PMID2757399.
^Hagerman AE, Rice ME, Ritchard NT (1998). "Mechanisms of Protein Precipitation for Two Tannins, Pentagalloyl Glucose and Epicatechin16(4→8) Catechin (Procyanidin)". Journal of Agricultural and Food Chemistry. 46 (7): 2590–2595.
doi:
10.1021/jf971097k.
^Gyémánt G, Zajácz A, Bécsi B, Ragunath C, Ramasubbu N, Erdodi F, Batta G, Kandra L (February 2009). "Evidence for pentagalloyl glucose binding to human salivary alpha-amylase through aromatic amino acid residues". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1794 (2): 291–6.
doi:
10.1016/j.bbapap.2008.10.012.
PMID19038368.
^
abPark E, Lee NH, Baik JS, Jee Y (August 2008). "Elaeocarpus sylvestris modulates gamma-ray-induced immunosuppression in mice: implications in radioprotection". Phytotherapy Research. 22 (8): 1046–51.
doi:
10.1002/ptr.2430.
PMID18570220.
S2CID44278609.
^
abNiemetz R, Gross GG (1998). "Gallotannin biosynthesis: Purification of β-glucogallin: 1,2,3,4,6-pentagalloyl-β-d-glucose galloyltransferase from sumac leavesfn1fn1In honour of Professor G. H. Neil Towers' 75th birthday". Phytochemistry. 49 (2): 327.
Bibcode:
1998PChem..49..327N.
doi:
10.1016/S0031-9422(98)00014-4.