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[acyl-carrier-protein] phosphodiesterase
Identifiers
EC no. 3.1.4.14
CAS no. 37288-21-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

The enzyme [acyl-carrier-protein] phosphodiesterase (EC 3.1.4.14) catalyzes the reaction

holo-[acyl-carrier-protein] + H2O 4-phosphopantetheine + apo-[acyl-carrier-protein]

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name is holo-[acyl-carrier-protein] 4-pantetheine-phosphohydrolase. Other names in common use include ACP hydrolyase, ACP phosphodiesterase, AcpH, and [acyl-carrier-protein] 4-pantetheine-phosphohydrolase. This enzyme participates in pantothenate and CoA biosynthesis.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T5B and 1TIK.

References

  • Sobhy C (1979). "Regulation of fatty acid synthetase activity. The 4-phosphopantetheine hydrolase of rat liver". J. Biol. Chem. 254 (17): 8561–6. PMID  224058.
  • Vagelos PR, Larrabes AR (1967). "Acyl carrier protein. IX. Acyl carrier protein hydrolase". J. Biol. Chem. 242 (8): 1776–81. PMID  4290442.
  • Thomas J, Cronan JE (2005). "The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization". J. Biol. Chem. 280 (41): 34675–83. doi: 10.1074/jbc.M505736200. PMID  16107329.