This enzyme belongs to the family of
oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The
systematic name of this enzyme class is (S)-2-hydroxy-acid:oxygen 2-oxidoreductase. Other names in common use include glycolate oxidase, hydroxy-acid oxidase A, hydroxy-acid oxidase B, oxidase, L-2-hydroxy acid, hydroxyacid oxidase A, L-alpha-hydroxy acid oxidase, and L-2-hydroxy acid oxidase. This enzyme participates in
glyoxylate and dicarboxylate metabolism. It employs one
cofactor,
FMN.
Structural studies
As of late 2007, 5
structures have been solved for this class of enzymes, with
PDB accession codes
1AL7,
1AL8,
1GYL,
1TB3, and
2NZL.
Nakano M, Ushijima Y, Saga M, Tsutsumi Y, Asami H (1968). "Aliphatic L-alpha-hydroxyacid oxidase from rat livers: purification and properties". Biochim. Biophys. Acta. 167 (1): 9–22.
doi:
10.1016/0005-2744(68)90273-8.
PMID5686300.