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Adaptation of pathogens to reduce the protection of vaccines
Vaccine resistance is the evolutionary adaptation of pathogens to infect and spread through vaccinated individuals, analogous to
antimicrobial resistance . It concerns both human and animal vaccines. Although the emergence of a number of vaccine resistant pathogens has been well documented, this phenomenon is nevertheless much more rare and less of a concern than antimicrobial resistance.
Vaccine resistance may be considered a special case of
immune evasion , from the immunity conferred by the vaccine. Since the immunity conferred by a vaccine may be different from that induced by infection by the pathogen, the immune evasion may also be easier (in case of an inefficient vaccine) or more difficult (would be the case of the
universal flu vaccine ). We speak of vaccine resistance only if the immune evasion is a result of evolutionary adaptation of the pathogen (and not a feature of the pathogen that it had before any evolutionary adaptation to the vaccine) and the adaptation is driven by the selective pressure induced by the vaccine (this would not be the case of an immune evasion that is the result of genetic drift that would be present even without vaccinating the population).[
citation needed ]
Some of the causes advanced for less frequent emergence of resistance are
[1]
[2] that
vaccines are mostly used for
prophylaxis , that is before infection occurs, and usually act to suppress the pathogen before the host becomes infectious
most vaccines target multiple
antigenic sites of the pathogen
different hosts may produce different immune responses to the same pathogen
For diseases that confer long lasting immunity after exposure, typically
childhood diseases , it was argued that a vaccine may provide the same immune response as natural infection, so it is expected that there should be no vaccine resistance.
[3]
[4]
If vaccine resistance emerges the vaccine may retain some level of protection against serious infection, possibly by modifying the immune response of the host away from
immunopathology .
[5]
The best known cases of vaccine resistance are for the following diseases
animal diseases
human diseases
Other less documented cases are for
avian influenza ,
[24]
avian reovirus ,
[25]
Corynebacterium diphtheriae ,
[26]
feline calicivirus ,
[27]
H. influenzae ,
[28]
infectious bursal disease virus ,
[29]
Neisseria meningitidis ,
[30]
Newcastle disease virus ,
[31] and
porcine circovirus type 2.
[32]
References
^ Kennedy, David A.; Read, Andrew F. (2017-03-29).
"Why does drug resistance readily evolve but vaccine resistance does not?" . Proceedings of the Royal Society B: Biological Sciences . 284 (1851): 20162562.
doi :
10.1098/rspb.2016.2562 .
ISSN
0962-8452 .
PMC
5378080 .
PMID
28356449 .
^ Kennedy, David A.; Read, Andrew F. (2018-12-18).
"Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance" . Proceedings of the National Academy of Sciences . 115 (51): 12878–12886.
Bibcode :
2018PNAS..11512878K .
doi :
10.1073/pnas.1717159115 .
PMC
6304978 .
PMID
30559199 .
^ McLean, Angela Ruth (1995-09-22).
"Vaccination, evolution and changes in the efficacy of vaccines: a theoretical framework" . Proceedings of the Royal Society of London. Series B: Biological Sciences . 261 (1362): 389–393.
Bibcode :
1995RSPSB.261..389M .
doi :
10.1098/rspb.1995.0164 .
PMID
8587880 .
S2CID
24978821 .
^ Mclean, A. R (1998-01-01).
"Vaccines and their impact on the control of disease" . British Medical Bulletin . 54 (3): 545–556.
doi :
10.1093/oxfordjournals.bmb.a011709 .
ISSN
0007-1420 .
PMID
10326283 .
^ Graham, Andrea L.; Allen, Judith E.; Read, Andrew F. (2005-11-10).
"Evolutionary Causes and Consequences of Immunopathology" . Annual Review of Ecology, Evolution, and Systematics . 36 (1): 373–397.
doi :
10.1146/annurev.ecolsys.36.102003.152622 .
ISSN
1543-592X .
^ Witter, R. L. (1997).
"Increased Virulence of Marek's Disease Virus Field Isolates" . Avian Diseases . 41 (1): 149–163.
doi :
10.2307/1592455 .
ISSN
0005-2086 .
JSTOR
1592455 .
PMID
9087332 .
^ Read, Andrew F.; Baigent, Susan J.; Powers, Claire; Kgosana, Lydia B.; Blackwell, Luke; Smith, Lorraine P.; Kennedy, David A.; Walkden-Brown, Stephen W.; Nair, Venugopal K. (2015-07-27).
"Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens" . PLOS Biology . 13 (7): e1002198.
doi :
10.1371/journal.pbio.1002198 .
ISSN
1545-7885 .
PMC
4516275 .
PMID
26214839 .
^ Austin, D.A.; Robertson, P.A.W.; Austin, B. (2003-01-01).
"Recovery of a New Biogroup of Yersinia ruckeri from Diseased Rainbow Trout (Oncorhynchus mykiss, Walbaum)" . Systematic and Applied Microbiology . 26 (1): 127–131.
doi :
10.1078/072320203322337416 .
ISSN
0723-2020 .
PMID
12747420 .
^ Welch, Timothy J.; Verner-Jeffreys, David W.; Dalsgaard, Inger; Wiklund, Thomas; Evenhuis, Jason P.; Garcia Cabrera, Jose A.; Hinshaw, Jeffrey M.; Drennan, John D.; Lapatra, Scott E. (2011).
"Independent Emergence of Yersinia ruckeri Biotype 2 in the United States and Europe" . Applied and Environmental Microbiology . 77 (10): 3493–3499.
Bibcode :
2011ApEnM..77.3493W .
doi :
10.1128/aem.02997-10 .
PMC
3126439 .
PMID
21441334 .
^ Banet-Noach, Caroline; Simanov, Lubov; Laham-Karam, Nihay; Perk, Shimon; Bacharach, Eran (2009).
"Longitudinal Survey of Avian Metapneumoviruses in Poultry in Israel: Infiltration of Field Strains into Vaccinated Flocks" . Avian Diseases . 53 (2): 184–189.
doi :
10.1637/8466-090408-Reg.1 .
ISSN
0005-2086 .
JSTOR
25599093 .
PMID
19630222 .
S2CID
21433553 .
^ Catelli, Elena; Lupini, Caterina; Cecchinato, Mattia; Ricchizzi, Enrico; Brown, Paul; Naylor, Clive J. (2010-01-22).
"Field avian Metapneumovirus evolution avoiding vaccine induced immunity" . Vaccine . 28 (4): 916–921.
doi :
10.1016/j.vaccine.2009.10.149 .
ISSN
0264-410X .
PMID
19931381 .
^ Cecchinato, Mattia; Catelli, Elena; Lupini, Caterina; Ricchizzi, Enrico; Clubbe, Jayne; Battilani, Mara; Naylor, Clive J. (2010-11-20).
"Avian metapneumovirus (AMPV) attachment protein involvement in probable virus evolution concurrent with mass live vaccine introduction" . Veterinary Microbiology . 146 (1–2): 24–34.
doi :
10.1016/j.vetmic.2010.04.014 .
ISSN
0378-1135 .
PMID
20447777 .
^ Naylor, Clive J.; Ling, Roger; Edworthy, Nicole; Savage, Carol E.; Easton, Andrew J.YR 2007 (2007).
"Avian metapneumovirus SH gene end and G protein mutations influence the level of protection of live-vaccine candidates" . Journal of General Virology . 88 (6): 1767–1775.
doi :
10.1099/vir.0.82755-0 .
ISSN
1465-2099 .
PMID
17485538 . {{
cite journal }}
: CS1 maint: numeric names: authors list (
link )
^ Weinberger, Daniel M; Malley, Richard; Lipsitch, Marc (December 2011).
"Serotype replacement in disease after pneumococcal vaccination" . The Lancet . 378 (9807): 1962–1973.
doi :
10.1016/s0140-6736(10)62225-8 .
ISSN
0140-6736 .
PMC
3256741 .
PMID
21492929 .
^ Brueggemann, Angela B.; Pai, Rekha; Crook, Derrick W.; Beall, Bernard (2007-11-16).
"Vaccine Escape Recombinants Emerge after Pneumococcal Vaccination in the United States" . PLOS Pathogens . 3 (11): e168.
doi :
10.1371/journal.ppat.0030168 .
ISSN
1553-7374 .
PMC
2077903 .
PMID
18020702 .
^ Carman, W.F.; Karayiannis, P.; Waters, J.; Thomas, H.C.; Zanetti, A.R.; Manzillo, G.; Zuckerman, A.J. (August 1990).
"Vaccine-induced escape mutant of hepatitis B virus" . The Lancet . 336 (8711): 325–329.
doi :
10.1016/0140-6736(90)91874-a .
ISSN
0140-6736 .
PMID
1697396 .
S2CID
45479217 .
^ Zanetti, A.R.; Tanzi, E.; Manzillo, G.; Maio, G.; Sbreglia, C.; Caporaso, N.; Thomas, Howard; Zuckerman, ArieJ. (November 1988).
"Hepatitis B Variant in Europe" . The Lancet . 332 (8620): 1132–1133.
doi :
10.1016/s0140-6736(88)90541-7 .
ISSN
0140-6736 .
PMID
2460710 .
S2CID
2638727 .
^ Romanò, Luisa; Paladini, Sara; Galli, Cristina; Raimondo, Giovanni; Pollicino, Teresa; Zanetti, Alessandro R. (2015-01-01).
"Hepatitis B vaccination" . Human Vaccines & Immunotherapeutics . 11 (1): 53–57.
doi :
10.4161/hv.34306 .
ISSN
2164-5515 .
PMC
4514213 .
PMID
25483515 .
^ Sheldon, J.; Soriano, V. (2008-02-04).
"Hepatitis B virus escape mutants induced by antiviral therapy" . Journal of Antimicrobial Chemotherapy . 61 (4): 766–768.
doi :
10.1093/jac/dkn014 .
ISSN
0305-7453 .
PMID
18218641 .
^ Mooi, F. R.; van Oirschot, H.; Heuvelman, K.; van der Heide, H. G.; Gaastra, W.; Willems, R. J. (February 1998).
"Polymorphism in the Bordetella pertussis virulence factors P.69/pertactin and pertussis toxin in The Netherlands: temporal trends and evidence for vaccine-driven evolution" . Infection and Immunity . 66 (2): 670–675.
doi :
10.1128/IAI.66.2.670-675.1998 .
ISSN
0019-9567 .
PMC
107955 .
PMID
9453625 .
^ Kallonen, Teemu; He, Qiushui (2009-07-01).
"Bordetella pertussis strain variation and evolution postvaccination" . Expert Review of Vaccines . 8 (7): 863–875.
doi :
10.1586/erv.09.46 .
ISSN
1476-0584 .
PMID
19538113 .
S2CID
22946846 .
^ Hegerle, Nicolas; Guiso, Nicole (2014-09-01).
"Bordetella pertussis and pertactin-deficient clinical isolates: lessons for pertussis vaccines" . Expert Review of Vaccines . 13 (9): 1135–1146.
doi :
10.1586/14760584.2014.932254 .
ISSN
1476-0584 .
PMID
24953157 .
S2CID
21534501 .
^ Safarchi, Azadeh; Octavia, Sophie; Luu, Laurence Don Wai; Tay, Chin Yen; Sintchenko, Vitali; Wood, Nicholas; Marshall, Helen; McIntyre, Peter; Lan, Ruiting (2015-11-17).
"Pertactin negative Bordetella pertussis demonstrates higher fitness under vaccine selection pressure in a mixed infection model" . Vaccine . 33 (46): 6277–6281.
doi :
10.1016/j.vaccine.2015.09.064 .
ISSN
0264-410X .
PMID
26432908 .
^ Lee, Chang-Won; Senne, Dennis A.; Suarez, David L. (2004).
"Effect of Vaccine Use in the Evolution of Mexican Lineage H5N2 Avian Influenza Virus" . Journal of Virology . 78 (15): 8372–8381.
doi :
10.1128/jvi.78.15.8372-8381.2004 .
PMC
446090 .
PMID
15254209 .
^ Lu, Huaguang; Tang, Yi; Dunn, Patricia A.; Wallner-Pendleton, Eva A.; Lin, Lin; Knoll, Eric A. (2015-10-15).
"Isolation and molecular characterization of newly emerging avian reovirus variants and novel strains in Pennsylvania, USA, 2011–2014" . Scientific Reports . 5 (1): 14727.
Bibcode :
2015NatSR...514727L .
doi :
10.1038/srep14727 .
ISSN
2045-2322 .
PMC
4606735 .
PMID
26469681 .
^ Soubeyrand, Benoit; Plotkin, Stanley A. (June 2002).
"Antitoxin vaccines and pathogen virulence" . Nature . 417 (6889): 609–610.
doi :
10.1038/417609b .
ISSN
1476-4687 .
PMID
12050654 .
S2CID
4408258 .
^ Radford, Alan D.; Dawson, Susan; Coyne, Karen P.; Porter, Carol J.; Gaskell, Rosalind M. (2006-10-05).
"The challenge for the next generation of feline calicivirus vaccines" . Veterinary Microbiology . 117 (1): 14–18.
doi :
10.1016/j.vetmic.2006.04.004 .
ISSN
0378-1135 .
PMID
16698199 .
^ Ribeiro, Guilherme S.; Reis, Joice N.; Cordeiro, Soraia M.; Lima, Josilene B. T.; Gouveia, Edilane L.; Petersen, Maya; Salgado, Kátia; Silva, Hagamenon R.; Zanella, Rosemeire Cobo; Almeida, Samanta C. Grassi; Brandileone, Maria Cristina (January 2003).
"Prevention ofHaemophilus influenzaeType b (Hib) Meningitis and Emergence of Serotype Replacement with Type a Strains after Introduction of Hib Immunization in Brazil" . The Journal of Infectious Diseases . 187 (1): 109–116.
doi :
10.1086/345863 .
ISSN
0022-1899 .
PMID
12508153 .
^ Berg, Thierry P. Van Den (2000-06-01).
"Acute infectious bursal disease in poultry: A review" . Avian Pathology . 29 (3): 175–194.
doi :
10.1080/03079450050045431 .
ISSN
0307-9457 .
PMID
19184804 .
S2CID
23178744 .
^ Kertesz, Daniel A.; Coulthart, Michael B.; Ryan, J. Alan; Johnson, Wendy M.; Ashton, Fraser E. (June 1998).
"Serogroup B, Electrophoretic Type 15 Neisseria meningitidis in Canada" . The Journal of Infectious Diseases . 177 (6): 1754–1757.
doi :
10.1086/517439 .
ISSN
0022-1899 .
PMID
9607865 .
^ Boven, Michiel van; Bouma, Annemarie; Fabri, Teun H. F.; Katsma, Elly; Hartog, Leo; Koch, Guus (2008-02-01).
"Herd immunity to Newcastle disease virus in poultry by vaccination" . Avian Pathology . 37 (1): 1–5.
doi :
10.1080/03079450701772391 .
ISSN
0307-9457 .
PMC
2556191 .
PMID
18202943 .
^ Franzo, Giovanni; Tucciarone, Claudia Maria; Cecchinato, Mattia; Drigo, Michele (2016-12-19).
"Porcine circovirus type 2 (PCV2) evolution before and after the vaccination introduction: A large scale epidemiological study" . Scientific Reports . 6 (1): 39458.
Bibcode :
2016NatSR...639458F .
doi :
10.1038/srep39458 .
ISSN
2045-2322 .
PMC
5171922 .
PMID
27991573 .