|Regions with significant populations|
|New York City Metropolitan Area,     New Jersey, Philadelphia, Pittsburgh, Cleveland, Chicago, San Antonio, Houston, San Francisco, San Jose, Los Angeles|
|Islam, Judaism, Orthodox Christianity|
|Related ethnic groups|
|Other Turkic peoples|
Since the late 1950s, over 1,000 Uzbek families migrated to the United States, according to unofficial data. The first of them came from Europe, but from the mid-1960s they mainly came from Turkey and, to a lesser extent, Saudi Arabia and elsewhere.
A wave of Uzbek immigrants to the United States settled in the country in the 1980s, because of the Soviet invasion of Afghanistan. From the early 1990s to the present day, most of the Uzbeks who migrate go to the U.S. 
Every year, around 6,000–7,800 Uzbeks win the green card lottery. Thus, more than 20,000 ethnic Uzbeks are citizens of the United States today.  The greater percentages of Uzbeks live mainly in New York, San Antonio, Houston, Philadelphia and New Jersey, growing rapidly in populations particularly in the boroughs of Brooklyn and Queens in New York City and in Northern New Jersey. However, smaller pockets of Uzbek Americans can be found in other major American metropolitan areas, such as Chicago, Cleveland, and Pittsburgh. The years of 2012 and 2013 had the largest migration of Uzbeks to the United States in history, much more so than the 1,000–1,800 green card lottery winners that were originally set in place.
Most Uzbek migrants are engaged in business and science, working in various institutions and companies. Part of the Uzbek diaspora is involved in government offices, schools and colleges of the country, as well as in areas like defense, aviation and medicine. Some representatives of the Uzbek diaspora hold senior executive positions in a number of American states. 
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As with other ethnic groups in the United States, Uzbek Americans also have several cultural associations. The Central Asian Foundation, established in July 2015, is a non-profit organization that promotes the social welfare of its members by developing and fostering cultural and social awareness and relations between the American and Central Asian communities in the United States. 
By other way, from December 13, 1958, Uzbeks of USA formed the "Turkestan -America" Association (ATA) in Philadelphia, which joined the citizens of the former Soviet Turkestan living in United States, taking advantage the growing number of immigrants in the United States of Central Asian origin. Under federal law the U.S. first registered Association in Philadelphia and, later (in 1961), it was recorded in New York. 
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- "PLACE OF BIRTH FOR THE FOREIGN-BORN POPULATION IN THE UNITED STATES, Universe: Foreign-born population excluding population born at sea, 2014 American Community Survey 5-Year Estimates". United States Census Bureau. Archived from the original on 14 February 2020. Retrieved 1 April 2018.
- "Yearbook of Immigration Statistics: 2013 Lawful Permanent Residents Supplemental Table 2". U.S. Department of Homeland Security. Retrieved 2014-07-19.
- "Yearbook of Immigration Statistics: 2012 Supplemental Table 2". U.S. Department of Homeland Security. Retrieved 2014-07-19.
- "Yearbook of Immigration Statistics: 2011 Supplemental Table 2". U.S. Department of Homeland Security. Retrieved 2014-07-19.
- "Yearbook of Immigration Statistics: 2010 Supplemental Table 2". U.S. Department of Homeland Security. Retrieved 2014-07-19.
- US DoS Bureau of Consular Affairs Statistics US DoS Bureau of Consular Affairs Statistics
- Этнические узбеки в США (in Russian: New Study: U.S. Uzbeks)
- Новое исследование: Американские узбеки Archived 2013-12-03 at the Wayback Machine (in Russian: ethnic Uzbeks in the U.S.)
- "Главная - Central Asian Foundation". Central Asian Foundation (in Russian). Retrieved 2018-04-16.