From Wikipedia, the free encyclopedia

The historical application of biotechnology throughout time is provided below in chronological order.

These discoveries, inventions and modifications are evidence of the application of biotechnology since before the common era and describe notable events in the research, development and regulation of biotechnology.

Before Common Era

Pre-20th century

20th century

21st century


8 July: Researchers report that they succeeded in using a genetically altered variant of R. sulfidophilum to produce spidroins, the main proteins in spider silk. [68]
  • 18 September – Researchers report the development of two active guide RNA-only elements that, according to their study, may enable halting or deleting gene drives introduced into populations in the wild with CRISPR-Cas9 gene editing. The paper's senior author cautions that the two neutralizing systems they demonstrated in cage trials "should not be used with a false sense of security for field-implemented gene drives". [80] [81]
10 November: Scientists show that microorganisms could be employed to mine useful elements from basalt rocks in space. [86]
25 November: The development of a biotechnology for microbial reactors capable of producing oxygen as well as hydrogen is reported. [90]
30 November: The 50-year problem of protein structure prediction is reported to be largely solved with an AI algorithm. [92]


Researchers present a bioprinting method to produce steak-like cultured meat.
  • 0 Researchers present a bioprinting method to produce steak-like cultured meat, composed of three types of bovine cell fibers. [141] [142]
  • Bioengineers report the development of a viable CRISPR-Cas gene-editing system, "CasMINI", that is about twice as compact as the commonly used Cas9 and Cas12a. [143] [144]
  • Media outlets report that the world's first cultured coffee product has been created, still awaiting regulatory approval for near-term commercialization. It was also reported that another biotechnology company produced and sold "molecular coffee" without clear details of the molecular composition or similarity to cultured coffee except having compounds that are in green coffee and that a third company is working on the development of a similar product made from extracted molecules. [145] [146] [147] Such products, for which multiple companies' R&D have acquired substantial funding, may have equal or highly similar effects, composition and taste as natural products but use less water, generate less carbon emissions, require less and relocated labor [146] and cause no deforestation. [145]
The first CRISPR-edited food, tomatoes, goes on public sale.


Researchers introduce and demonstrate the concept of necrobotics.
Remote controlled cyborg cockroaches.

Medical applications

Some of these items may also have potential nonmedical applications and vice versa.

A new CRISPR gene editing/repair tool alternative to fully active Cas9 is reported.
Wastewater surveillance is used to detect monkeypox [297]


Safety-by-design ways like DNA screening for biosafety and biosecurity to prevent engineered pandemics
A bone-like biocomposite 3D printing ink, BactoInk
Scientists coin and outline a new field ' organoid intelligence' (OI)

Medical applications

See also



  1. ^ a b "Highlights in the History of Biotechnology" (PDF). St Louis Science Center. Archived from the original (PDF) on 23 January 2013. Retrieved 27 December 2012.
  2. ^ "Agriculture in Ancient Greece". World History Encyclopedia. Archived from the original on 30 December 2012. Retrieved 27 December 2012.
  3. ^ "Biotechnology Timeline". Biotechnology Institute of Washington DC. Archived from the original on April 7, 2022. Retrieved 27 December 2012.
  4. ^ Ereky, Karl. (June 8, 1919). Biotechnologie der Fleisch-, Fett-, und Milcherzeugung im landwirtschaftlichen Grossbetriebe: für naturwissenschaftlich gebildete Landwirte verfasst. P. Parey – via Hathi Trust.
  5. ^ "1973_Boyer". Genome News Network. Archived from the original on 20 September 2020. Retrieved 19 August 2015.
  6. ^ C A Hutchison, 3rd, S Phillips, M H Edgell, S Gillam, P Jahnke and M Smith (1978). "Mutagenesis at a specific position in a DNA sequence". J Biol Chem. 253 (18): 6551–6560. doi: 10.1016/S0021-9258(19)46967-6. PMID  681366.{{ cite journal}}: CS1 maint: multiple names: authors list ( link) CS1 maint: numeric names: authors list ( link)
  7. ^ Fingas, Jon (16 April 2019). "CRISPR gene editing has been used on humans in the US". Engadget. Archived from the original on 16 April 2019. Retrieved 16 April 2019.
  8. ^ Staff (17 April 2019). "CRISPR has been used to treat US cancer patients for the first time". MIT Technology Review. Archived from the original on 17 April 2019. Retrieved 17 April 2019.
  9. ^ Anzalone, Andrew V.; Randolph, Peyton B.; Davis, Jessie R.; Sousa, Alexander A.; Koblan, Luke W.; Levy, Jonathan M.; Chen, Peter J.; Wilson, Christopher; Newby, Gregory A.; Raguram, Aditya; Liu, David R. (21 October 2019). "Search-and-replace genome editing without double-strand breaks or donor DNA". Nature. 576 (7785): 149–157. Bibcode: 2019Natur.576..149A. doi: 10.1038/s41586-019-1711-4. PMC  6907074. PMID  31634902.
  10. ^ Gallagher, James (2019-10-21). "Prime editing: DNA tool could correct 89% of genetic defects". BBC News. Archived from the original on 2019-10-21. Retrieved 21 October 2019.
  11. ^ "Scientists Create New, More Powerful Technique To Edit Genes". Archived from the original on 21 October 2019. Retrieved 21 October 2019.
  12. ^ "Nanoparticle chomps away plaques that cause heart attacks". Michigan State University. 27 January 2020. Archived from the original on 29 January 2020. Retrieved 31 January 2020.
  13. ^ "Nanoparticle helps eat away deadly arterial plaque". New Atlas. 28 January 2020. Archived from the original on 1 March 2020. Retrieved 13 April 2020.
  14. ^ Flores, Alyssa M.; Hosseini-Nassab, Niloufar; Jarr, Kai-Uwe; Ye, Jianqin; Zhu, Xingjun; Wirka, Robert; Koh, Ai Leen; Tsantilas, Pavlos; Wang, Ying; Nanda, Vivek; Kojima, Yoko; Zeng, Yitian; Lotfi, Mozhgan; Sinclair, Robert; Weissman, Irving L.; Ingelsson, Erik; Smith, Bryan Ronain; Leeper, Nicholas J. (February 2020). "Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis". Nature Nanotechnology. 15 (2): 154–161. Bibcode: 2020NatNa..15..154F. doi: 10.1038/s41565-019-0619-3. PMC  7254969. PMID  31988506.
  15. ^ "Fundamental beliefs about atherosclerosis overturned: Complications of artery-hardening condition are number one killer worldwide". ScienceDaily. Archived from the original on 2020-06-29. Retrieved 2020-07-12.
  16. ^ "The top 10 causes of death". Archived from the original on 2020-06-05. Retrieved 2020-01-26.
  17. ^ "New CRISPR-based tool can probe and control several genetic circuits at once". Archived from the original on 2 March 2020. Retrieved 8 March 2020.
  18. ^ Kempton, Hannah R.; Goudy, Laine E.; Love, Kasey S.; Qi, Lei S. (5 February 2020). "Multiple Input Sensing and Signal Integration Using a Split Cas12a System". Molecular Cell. 78 (1): 184–191.e3. doi: 10.1016/j.molcel.2020.01.016. ISSN  1097-2765. PMID  32027839.
  19. ^ AFP (7 February 2020). "US Trial Shows 3 Cancer Patients Had Their Genomes Altered Safely by CRISPR". ScienceAlert. Archived from the original on 2020-02-08. Retrieved 2020-02-09.
  20. ^ "CRISPR-edited immune cells for fighting cancer passed a safety test". Science News. 6 February 2020. Archived from the original on 25 July 2020. Retrieved 13 July 2020.
  21. ^ "CRISPR-Edited Immune Cells Can Survive and Thrive After Infusion into Cancer Patients – PR News". Archived from the original on 13 July 2020. Retrieved 13 July 2020.
  22. ^ Stadtmauer, Edward A.; Fraietta, Joseph A.; Davis, Megan M.; Cohen, Adam D.; Weber, Kristy L.; Lancaster, Eric; Mangan, Patricia A.; Kulikovskaya, Irina; Gupta, Minnal; Chen, Fang; Tian, Lifeng; Gonzalez, Vanessa E.; Xu, Jun; Jung, In-young; Melenhorst, J. Joseph; Plesa, Gabriela; Shea, Joanne; Matlawski, Tina; Cervini, Amanda; Gaymon, Avery L.; Desjardins, Stephanie; Lamontagne, Anne; Salas-Mckee, January; Fesnak, Andrew; Siegel, Donald L.; Levine, Bruce L.; Jadlowsky, Julie K.; Young, Regina M.; Chew, Anne; Hwang, Wei-Ting; Hexner, Elizabeth O.; Carreno, Beatriz M.; Nobles, Christopher L.; Bushman, Frederic D.; Parker, Kevin R.; Qi, Yanyan; Satpathy, Ansuman T.; Chang, Howard Y.; Zhao, Yangbing; Lacey, Simon F.; June, Carl H. (28 February 2020). "CRISPR-engineered T cells in patients with refractory cancer". Science. 367 (6481): eaba7365. doi: 10.1126/science.aba7365. ISSN  0036-8075. PMID  32029687. S2CID  211048335.
  23. ^ "Biomaterial discovery enables 3-D printing of tissue-like vascular structures". Archived from the original on 6 April 2020. Retrieved 5 April 2020.
  24. ^ Wu, Yuanhao; Okesola, Babatunde O.; Xu, Jing; Korotkin, Ivan; Berardo, Alice; Corridori, Ilaria; di Brocchetti, Francesco Luigi Pellerej; Kanczler, Janos; Feng, Jingyu; Li, Weiqi; Shi, Yejiao; Farafonov, Vladimir; Wang, Yiqiang; Thompson, Rebecca F.; Titirici, Maria-Magdalena; Nerukh, Dmitry; Karabasov, Sergey; Oreffo, Richard O. C.; Carlos Rodriguez-Cabello, Jose; Vozzi, Giovanni; Azevedo, Helena S.; Pugno, Nicola M.; Wang, Wen; Mata, Alvaro (4 March 2020). "Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices". Nature Communications. 11 (1): 1182. Bibcode: 2020NatCo..11.1182W. doi: 10.1038/s41467-020-14716-z. ISSN  2041-1723. PMC  7055247. PMID  32132534.
  25. ^ "Doctors use gene editing tool Crispr inside body for first time". The Guardian. 4 March 2020. Archived from the original on 12 April 2020. Retrieved 6 April 2020.
  26. ^ "Doctors use CRISPR gene editing inside a person's body for first time". NBC News. Archived from the original on 6 March 2020. Retrieved 6 April 2020.
  27. ^ "Doctors try 1st CRISPR editing in the body for blindness". AP NEWS. 4 March 2020. Archived from the original on 6 April 2020. Retrieved 6 April 2020.
  28. ^ White, Franny. "OHSU performs first-ever CRISPR gene editing within human body". OHSU News. Retrieved 12 April 2020.
  29. ^ "Researchers establish new viable CRISPR-Cas12b system for plant genome engineering". Archived from the original on 6 April 2020. Retrieved 6 April 2020.
  30. ^ Ming, Meiling; Ren, Qiurong; Pan, Changtian; He, Yao; Zhang, Yingxiao; Liu, Shishi; Zhong, Zhaohui; Wang, Jiaheng; Malzahn, Aimee A.; Wu, Jun; Zheng, Xuelian; Zhang, Yong; Qi, Yiping (March 2020). "CRISPR–Cas12b enables efficient plant genome engineering". Nature Plants. 6 (3): 202–208. doi: 10.1038/s41477-020-0614-6. PMID  32170285. S2CID  212643374.
  31. ^ Levy, Steven. "Could Crispr Be Humanity's Next Virus Killer?". Wired. Archived from the original on 24 March 2020. Retrieved 25 March 2020.
  32. ^ "Biochemist Explains How CRISPR Can Be Used to Fight COVID-19". Amanpour & Company. Archived from the original on 30 April 2020. Retrieved 3 April 2020.
  33. ^ "Can Crispr technology attack the coronavirus? | Bioengineering". 18 March 2020. Archived from the original on 14 July 2020. Retrieved 3 April 2020.
  34. ^ Abbott, Timothy R.; Dhamdhere, Girija; Liu, Yanxia; Lin, Xueqiu; Goudy, Laine; Zeng, Leiping; Chemparathy, Augustine; Chmura, Stephen; Heaton, Nicholas S.; Debs, Robert; Pande, Tara; Endy, Drew; Russa, Marie La; Lewis, David B.; Qi, Lei S. (14 March 2020). "Development of CRISPR as a prophylactic strategy to combat novel coronavirus and influenza". bioRxiv: 2020.03.13.991307. doi: 10.1101/2020.03.13.991307.
  35. ^ "Scientists aim gene-targeting breakthrough against COVID-19". Archived from the original on 17 June 2020. Retrieved 13 June 2020.
  36. ^ Abbott, Timothy R.; Dhamdhere, Girija; Liu, Yanxia; Lin, Xueqiu; Goudy, Laine; Zeng, Leiping; Chemparathy, Augustine; Chmura, Stephen; Heaton, Nicholas S.; Debs, Robert; Pande, Tara; Endy, Drew; Russa, Marie F. La; Lewis, David B.; Qi, Lei S. (14 May 2020). "Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza". Cell. 181 (4): 865–876.e12. doi: 10.1016/j.cell.2020.04.020. ISSN  0092-8674. PMC  7189862. PMID  32353252.
  37. ^ "New kind of CRISPR technology to target RNA, including RNA viruses like coronavirus". Archived from the original on 5 April 2020. Retrieved 3 April 2020.
  38. ^ Wessels, Hans-Hermann; Méndez-Mancilla, Alejandro; Guo, Xinyi; Legut, Mateusz; Daniloski, Zharko; Sanjana, Neville E. (16 March 2020). "Massively parallel Cas13 screens reveal principles for guide RNA design". Nature Biotechnology. 38 (6): 722–727. doi: 10.1038/s41587-020-0456-9. PMC  7294996. PMID  32518401.
  39. ^ "Scientists can now edit multiple genome fragments at a time". Archived from the original on 7 April 2020. Retrieved 7 April 2020.
  40. ^ Gonatopoulos-Pournatzis, Thomas; Aregger, Michael; Brown, Kevin R.; Farhangmehr, Shaghayegh; Braunschweig, Ulrich; Ward, Henry N.; Ha, Kevin C. H.; Weiss, Alexander; Billmann, Maximilian; Durbic, Tanja; Myers, Chad L.; Blencowe, Benjamin J.; Moffat, Jason (16 March 2020). "Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9–Cas12a platform". Nature Biotechnology. 38 (5): 638–648. doi: 10.1038/s41587-020-0437-z. PMID  32249828. S2CID  212731918.
  41. ^ "Researchers achieve remote control of hormone release using magnetic nanoparticles". Archived from the original on 24 April 2020. Retrieved 16 May 2020.
  42. ^ Rosenfeld, Dekel; Senko, Alexander W.; Moon, Junsang; Yick, Isabel; Varnavides, Georgios; Gregureć, Danijela; Koehler, Florian; Chiang, Po-Han; Christiansen, Michael G.; Maeng, Lisa Y.; Widge, Alik S.; Anikeeva, Polina (1 April 2020). "Transgene-free remote magnetothermal regulation of adrenal hormones". Science Advances. 6 (15): eaaz3734. Bibcode: 2020SciA....6.3734R. doi: 10.1126/sciadv.aaz3734. PMC  7148104. PMID  32300655.
  43. ^ "Predicting the evolution of genetic mutations". Archived from the original on 26 April 2020. Retrieved 16 May 2020.
  44. ^ Zhou, Juannan; McCandlish, David M. (14 April 2020). "Minimum epistasis interpolation for sequence-function relationships". Nature Communications. 11 (1): 1782. Bibcode: 2020NatCo..11.1782Z. doi: 10.1038/s41467-020-15512-5. PMC  7156698. PMID  32286265.
  45. ^ "Bactericidal nanomachine: Researchers reveal the mechanisms behind a natural bacteria killer". Archived from the original on 29 April 2020. Retrieved 17 May 2020.
  46. ^ Ge, Peng; Scholl, Dean; Prokhorov, Nikolai S.; Avaylon, Jaycob; Shneider, Mikhail M.; Browning, Christopher; Buth, Sergey A.; Plattner, Michel; Chakraborty, Urmi; Ding, Ke; Leiman, Petr G.; Miller, Jeff F.; Zhou, Z. Hong (April 2020). "Action of a minimal contractile bactericidal nanomachine". Nature. 580 (7805): 658–662. Bibcode: 2020Natur.580..658G. doi: 10.1038/s41586-020-2186-z. PMC  7513463. PMID  32350467.
  47. ^ "Scientists create tiny devices that work like the human brain". The Independent. 20 April 2020. Archived from the original on 24 April 2020. Retrieved 17 May 2020.
  48. ^ "Researchers unveil electronics that mimic the human brain in efficient learning". Archived from the original on 28 May 2020. Retrieved 17 May 2020.
  49. ^ Fu, Tianda; Liu, Xiaomeng; Gao, Hongyan; Ward, Joy E.; Liu, Xiaorong; Yin, Bing; Wang, Zhongrui; Zhuo, Ye; Walker, David J. F.; Joshua Yang, J.; Chen, Jianhan; Lovley, Derek R.; Yao, Jun (20 April 2020). "Bioinspired bio-voltage memristors". Nature Communications. 11 (1): 1861. Bibcode: 2020NatCo..11.1861F. doi: 10.1038/s41467-020-15759-y. PMC  7171104. PMID  32313096.
  50. ^ "Sustainable light achieved in living plants". Archived from the original on 27 May 2020. Retrieved 18 May 2020.
  51. ^ "Scientists use mushroom DNA to produce permanently-glowing plants". New Atlas. 28 April 2020. Archived from the original on 9 May 2020. Retrieved 18 May 2020.
  52. ^ "Scientists create glowing plants using mushroom genes". The Guardian. 27 April 2020. Archived from the original on 10 May 2020. Retrieved 18 May 2020.
  53. ^ Wehner, Mike (29 April 2020). "Scientists use bioluminescent mushrooms to create glow-in-the-dark plants". New York Post. Archived from the original on 24 May 2020. Retrieved 18 May 2020.
  54. ^ Woodyatt, Amy. "Scientists create glow-in-the-dark plants". CNN. Archived from the original on 20 May 2020. Retrieved 23 May 2020.
  55. ^ Mitiouchkina, Tatiana; Mishin, Alexander S.; Somermeyer, Louisa Gonzalez; Markina, Nadezhda M.; Chepurnyh, Tatiana V.; Guglya, Elena B.; Karataeva, Tatiana A.; Palkina, Kseniia A.; Shakhova, Ekaterina S.; Fakhranurova, Liliia I.; Chekova, Sofia V.; Tsarkova, Aleksandra S.; Golubev, Yaroslav V.; Negrebetsky, Vadim V.; Dolgushin, Sergey A.; Shalaev, Pavel V.; Shlykov, Dmitry; Melnik, Olesya A.; Shipunova, Victoria O.; Deyev, Sergey M.; Bubyrev, Andrey I.; Pushin, Alexander S.; Choob, Vladimir V.; Dolgov, Sergey V.; Kondrashov, Fyodor A.; Yampolsky, Ilia V.; Sarkisyan, Karen S. (27 April 2020). "Plants with genetically encoded autoluminescence". Nature Biotechnology. 38 (8): 944–946. doi: 10.1038/s41587-020-0500-9. PMC  7610436. PMID  32341562. S2CID  216559981.
  56. ^ "New technique makes thousands of semi-synthetic photosynthesis cells". New Atlas. 11 May 2020. Archived from the original on 25 May 2020. Retrieved 12 June 2020.
  57. ^ Barras, Colin (7 May 2020). "Cyber-spinach turns sunlight into sugar". Nature. doi: 10.1038/d41586-020-01396-4. PMID  32393873. S2CID  218598753.
  58. ^ "Researchers develop an artificial chloroplast". Archived from the original on 12 June 2020. Retrieved 12 June 2020.
  59. ^ Miller, Tarryn E.; Beneyton, Thomas; Schwander, Thomas; Diehl, Christoph; Girault, Mathias; McLean, Richard; Chotel, Tanguy; Claus, Peter; Cortina, Niña Socorro; Baret, Jean-Christophe; Erb, Tobias J. (8 May 2020). "Light-powered CO2 fixation in a chloroplast mimic with natural and synthetic parts" (PDF). Science. 368 (6491): 649–654. Bibcode: 2020Sci...368..649M. doi: 10.1126/science.aaz6802. PMC  7610767. PMID  32381722. S2CID  218552008.
  60. ^ "Synthetic red blood cells mimic natural ones, and have new abilities". Archived from the original on 13 June 2020. Retrieved 13 June 2020.
  61. ^ Guo, Jimin; Agola, Jacob Ongudi; Serda, Rita; Franco, Stefan; Lei, Qi; Wang, Lu; Minster, Joshua; Croissant, Jonas G.; Butler, Kimberly S.; Zhu, Wei; Brinker, C. Jeffrey (11 May 2020). "Biomimetic Rebuilding of Multifunctional Red Blood Cells: Modular Design Using Functional Components". ACS Nano. 14 (7): 7847–7859. doi: 10.1021/acsnano.9b08714. OSTI  1639054. PMID  32391687. S2CID  218584795.
  62. ^ Page, Michael Le. "Three people with inherited diseases successfully treated with CRISPR". New Scientist. Archived from the original on 26 June 2020. Retrieved 1 July 2020.
  63. ^ "More early data revealed from landmark CRISPR gene editing human trial". New Atlas. 17 June 2020. Archived from the original on 23 June 2020. Retrieved 1 July 2020.
  64. ^ "A Year In, 1st Patient To Get Gene Editing For Sickle Cell Disease Is Thriving". Archived from the original on 30 June 2020. Retrieved 1 July 2020.
  65. ^ "CRISPR Therapeutics and Vertex Announce New Clinical Data for Investigational Gene-Editing Therapy CTX001™ in Severe Hemoglobinopathies at the 25th Annual European Hematology Association (EHA) Congress | CRISPR Therapeutics". Archived from the original on 28 June 2020. Retrieved 1 July 2020.
  66. ^ "The powerhouses inside cells have been gene-edited for the first time". New Scientist. 8 July 2020. Archived from the original on 14 July 2020. Retrieved 12 July 2020.
  67. ^ Mok, Beverly Y.; de Moraes, Marcos H.; Zeng, Jun; Bosch, Dustin E.; Kotrys, Anna V.; Raguram, Aditya; Hsu, FoSheng; Radey, Matthew C.; Peterson, S. Brook; Mootha, Vamsi K.; Mougous, Joseph D.; Liu, David R. (July 2020). "A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing". Nature. 583 (7817): 631–637. Bibcode: 2020Natur.583..631M. doi: 10.1038/s41586-020-2477-4. ISSN  1476-4687. PMC  7381381. PMID  32641830.
  68. ^ a b "Spider silk made by photosynthetic bacteria". Archived from the original on 7 August 2020. Retrieved 16 August 2020.
  69. ^ Foong, Choon Pin; Higuchi-Takeuchi, Mieko; Malay, Ali D.; Oktaviani, Nur Alia; Thagun, Chonprakun; Numata, Keiji (2020-07-08). "A marine photosynthetic microbial cell factory as a platform for spider silk production". Communications Biology. Springer Science and Business Media LLC. 3 (1): 357. doi: 10.1038/s42003-020-1099-6. ISSN  2399-3642. PMC  7343832. PMID  32641733. Text and images are available under a Creative Commons Attribution 4.0 International License Archived 2017-10-16 at the Wayback Machine.
  70. ^ "Brain benefits of exercise can be gained with a single protein". Archived from the original on 20 August 2020. Retrieved 18 August 2020.
  71. ^ Horowitz, Alana M.; Fan, Xuelai; Bieri, Gregor; Smith, Lucas K.; Sanchez-Diaz, Cesar I.; Schroer, Adam B.; Gontier, Geraldine; Casaletto, Kaitlin B.; Kramer, Joel H.; Williams, Katherine E.; Villeda, Saul A. (10 July 2020). "Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain". Science. 369 (6500): 167–173. Bibcode: 2020Sci...369..167H. doi: 10.1126/science.aaw2622. ISSN  0036-8075. PMC  7879650. PMID  32646997. S2CID  220428681.
  72. ^ "Researchers discover 2 paths of aging and new insights on promoting healthspan". Archived from the original on 13 August 2020. Retrieved 17 August 2020.
  73. ^ Li, Yang; Jiang, Yanfei; Paxman, Julie; o'Laughlin, Richard; Klepin, Stephen; Zhu, Yuelian; Pillus, Lorraine; Tsimring, Lev S.; Hasty, Jeff; Hao, Nan (2020). "A programmable fate decision landscape underliessingle-cell aging in yeast". Science. 369 (6501): 325–329. Bibcode: 2020Sci...369..325L. doi: 10.1126/science.aax9552. PMC  7437498. PMID  32675375.
  74. ^ "Machine learning reveals recipe for building artificial proteins". Archived from the original on 3 August 2020. Retrieved 17 August 2020.
  75. ^ Russ, William P.; Figliuzzi, Matteo; Stocker, Christian; Barrat-Charlaix, Pierre; Socolich, Michael; Kast, Peter; Hilvert, Donald; Monasson, Remi; Cocco, Simona; Weigt, Martin; Ranganathan, Rama (2020). "An evolution-based model for designing chorismatemutase enzymes". Science. 369 (6502): 440–445. Bibcode: 2020Sci...369..440R. doi: 10.1126/science.aba3304. PMID  32703877. S2CID  220714458.
  76. ^ "Quest - Article - Update: ACE-031 Clinical Trials in Duchenne MD". Muscular Dystrophy Association. 6 January 2016. Archived from the original on 21 September 2020. Retrieved 16 October 2020.
  77. ^ Attie, Kenneth M.; Borgstein, Niels G.; Yang, Yijun; Condon, Carolyn H.; Wilson, Dawn M.; Pearsall, Amelia E.; Kumar, Ravi; Willins, Debbie A.; Seehra, Jas S.; Sherman, Matthew L. (2013). "A single ascending-dose study of muscle regulator ace-031 in healthy volunteers". Muscle & Nerve. 47 (3): 416–423. doi: 10.1002/mus.23539. ISSN  1097-4598. PMID  23169607. S2CID  19956237. Retrieved 16 October 2020.
  78. ^ "'Mighty mice' stay musclebound in space, boon for astronauts". Archived from the original on 1 October 2020. Retrieved 8 October 2020.
  79. ^ Lee, Se-Jin; Lehar, Adam; Meir, Jessica U.; Koch, Christina; Morgan, Andrew; Warren, Lara E.; Rydzik, Renata; Youngstrom, Daniel W.; Chandok, Harshpreet; George, Joshy; Gogain, Joseph; Michaud, Michael; Stoklasek, Thomas A.; Liu, Yewei; Germain-Lee, Emily L. (22 September 2020). "Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight". Proceedings of the National Academy of Sciences. 117 (38): 23942–23951. Bibcode: 2020PNAS..11723942L. doi: 10.1073/pnas.2014716117. ISSN  0027-8424. PMC  7519220. PMID  32900939.
  80. ^ "Biologists create new genetic systems to neutralize gene drives". Archived from the original on 9 October 2020. Retrieved 8 October 2020.
  81. ^ Xu, Xiang-Ru Shannon; Bulger, Emily A.; Gantz, Valentino M.; Klanseck, Carissa; Heimler, Stephanie R.; Auradkar, Ankush; Bennett, Jared B.; Miller, Lauren Ashley; Leahy, Sarah; Juste, Sara Sanz; Buchman, Anna; Akbari, Omar S.; Marshall, John M.; Bier, Ethan (18 September 2020). "Active Genetic Neutralizing Elements for Halting or Deleting Gene Drives". Molecular Cell. 80 (2): 246–262.e4. doi: 10.1016/j.molcel.2020.09.003. ISSN  1097-2765. PMID  32949493. S2CID  221806864.
  82. ^ Carrington, Damian (28 September 2020). "New super-enzyme eats plastic bottles six times faster". The Guardian. Archived from the original on 12 October 2020. Retrieved 12 October 2020.
  83. ^ "Plastic-eating enzyme 'cocktail' heralds new hope for plastic waste". Archived from the original on 11 October 2020. Retrieved 12 October 2020.
  84. ^ Knott, Brandon C.; Erickson, Erika; Allen, Mark D.; Gado, Japheth E.; Graham, Rosie; Kearns, Fiona L.; Pardo, Isabel; Topuzlu, Ece; Anderson, Jared J.; Austin, Harry P.; Dominick, Graham; Johnson, Christopher W.; Rorrer, Nicholas A.; Szostkiewicz, Caralyn J.; Copié, Valérie; Payne, Christina M.; Woodcock, H. Lee; Donohoe, Bryon S.; Beckham, Gregg T.; McGeehan, John E. (24 September 2020). "Characterization and engineering of a two-enzyme system for plastics depolymerization". Proceedings of the National Academy of Sciences. 117 (41): 25476–25485. Bibcode: 2020PNAS..11725476K. doi: 10.1073/pnas.2006753117. ISSN  0027-8424. PMC  7568301. PMID  32989159. Text and images are available under a Creative Commons Attribution 4.0 International License Archived 2017-10-16 at the Wayback Machine.
  85. ^ Wu, Katherine J.; Peltier, Elian (7 October 2020). "Nobel Prize in Chemistry Awarded to 2 Scientists for Work on Genome Editing - Emmanuelle Charpentier and Jennifer A. Doudna developed the Crispr tool, which can alter the DNA of animals, plants and microorganisms with high precision". The New York Times. Archived from the original on 8 October 2020. Retrieved 7 October 2020.
  86. ^ a b Cockell, Charles S.; Santomartino, Rosa; Finster, Kai; Waajen, Annemiek C.; Eades, Lorna J.; Moeller, Ralf; Rettberg, Petra; Fuchs, Felix M.; Van Houdt, Rob; Leys, Natalie; Coninx, Ilse; Hatton, Jason; Parmitano, Luca; Krause, Jutta; Koehler, Andrea; Caplin, Nicol; Zuijderduijn, Lobke; Mariani, Alessandro; Pellari, Stefano S.; Carubia, Fabrizio; Luciani, Giacomo; Balsamo, Michele; Zolesi, Valfredo; Nicholson, Natasha; Loudon, Claire-Marie; Doswald-Winkler, Jeannine; Herová, Magdalena; Rattenbacher, Bernd; Wadsworth, Jennifer; Craig Everroad, R.; Demets, René (10 November 2020). "Space station biomining experiment demonstrates rare earth element extraction in microgravity and Mars gravity". Nature Communications. 11 (1): 5523. Bibcode: 2020NatCo..11.5523C. doi: 10.1038/s41467-020-19276-w. ISSN  2041-1723. PMC  7656455. PMID  33173035. Available under CC BY 4.0 Archived 2017-10-16 at the Wayback Machine.
  87. ^ Crane, Leah. "Asteroid-munching microbes could mine materials from space rocks". New Scientist. Archived from the original on 7 December 2020. Retrieved 9 December 2020.
  88. ^ "TAU breakthrough may increase life expectancy in brain and ovarian cancers". Tel Aviv University. 18 November 2020. Archived from the original on 22 November 2020. Retrieved 23 November 2020.
  89. ^ Rosenblum, Daniel; Gutkin, Anna; Kedmi, Ranit; Ramishetti, Srinivas; Veiga, Nuphar; Jacobi, Ashley M.; Schubert, Mollie S.; Friedmann-Morvinski, Dinorah; Cohen, Zvi R.; Behlke, Mark A.; Lieberman, Judy; Peer, Dan (1 November 2020). "CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy". Science Advances. 6 (47): eabc9450. Bibcode: 2020SciA....6.9450R. doi: 10.1126/sciadv.abc9450. ISSN  2375-2548. PMC  7673804. PMID  33208369. S2CID  227068531.
  90. ^ a b "Research creates hydrogen-producing living droplets, paving way for alternative future energy source". Archived from the original on 16 December 2020. Retrieved 9 December 2020.
  91. ^ Xu, Zhijun; Wang, Shengliang; Zhao, Chunyu; Li, Shangsong; Liu, Xiaoman; Wang, Lei; Li, Mei; Huang, Xin; Mann, Stephen (25 November 2020). "Photosynthetic hydrogen production by droplet-based microbial micro-reactors under aerobic conditions". Nature Communications. 11 (1): 5985. Bibcode: 2020NatCo..11.5985X. doi: 10.1038/s41467-020-19823-5. ISSN  2041-1723. PMC  7689460. PMID  33239636. Available under CC BY 4.0 Archived 2017-10-16 at the Wayback Machine.
  92. ^ a b "One of biology's biggest mysteries 'largely solved' by AI". BBC News. 30 November 2020. Archived from the original on 30 November 2020. Retrieved 30 November 2020.
  93. ^ "DeepMind AI cracks 50-year-old problem of protein folding". The Guardian. 30 November 2020. Archived from the original on 30 November 2020. Retrieved 30 November 2020.
  94. ^ "AlphaFold: a solution to a 50-year-old grand challenge in biology". DeepMind. 30 November 2020. Archived from the original on 30 November 2020. Retrieved 30 November 2020.
  95. ^ Shanker, Deena (October 22, 2019). "These $50 Chicken Nuggets Were Grown in a Lab". Archived from the original on February 25, 2020. Retrieved February 27, 2020.
  96. ^ Corbyn, Zoë (January 19, 2020). "Out of the lab and into your frying pan: the advance of cultured meat". The Guardian. Archived from the original on February 11, 2020. Retrieved February 27, 2020.
  97. ^ Ives, Mike (2 December 2020). "Singapore Approves a Lab-Grown Meat Product, a Global First". The New York Times. Archived from the original on 22 January 2021. Retrieved 16 January 2021.
  98. ^ "Scientists build whole functioning thymus from human cells". Francis Crick Institute. 11 December 2020. Archived from the original on 14 December 2020. Retrieved 14 December 2020.
  99. ^ Campinoti, Sara; Gjinovci, Asllan; Ragazzini, Roberta; Zanieri, Luca; Ariza-McNaughton, Linda; Catucci, Marco; Boeing, Stefan; Park, Jong-Eun; Hutchinson, John C.; Muñoz-Ruiz, Miguel; Manti, Pierluigi G.; Vozza, Gianluca; Villa, Carlo E.; Phylactopoulos, Demetra-Ellie; Maurer, Constance; Testa, Giuseppe; Stauss, Hans J.; Teichmann, Sarah A.; Sebire, Neil J.; Hayday, Adrian C.; Bonnet, Dominique; Bonfanti, Paola (11 December 2020). "Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds". Nature Communications. 11 (1): 6372. Bibcode: 2020NatCo..11.6372C. doi: 10.1038/s41467-020-20082-7. ISSN  2041-1723. PMC  7732825. PMID  33311516. Available under CC BY 4.0 Archived 2017-10-16 at the Wayback Machine.
  100. ^ "Gene-editing produces tenfold increase in superbug slaying antibiotics". EurekAlert!. 12 January 2021. Archived from the original on 13 January 2021. Retrieved 13 January 2021.
  101. ^ Devine, Rebecca; McDonald, Hannah P.; Qin, Zhiwei; Arnold, Corinne J.; Noble, Katie; Chandra, Govind; Wilkinson, Barrie; Hutchings, Matthew I. (12 January 2021). "Re-wiring the regulation of the formicamycin biosynthetic gene cluster to enable the development of promising antibacterial compounds". Cell Chemical Biology. 28 (4): 515–523.e5. doi: 10.1016/j.chembiol.2020.12.011. ISSN  2451-9456. PMC  8062789. PMID  33440167.
  102. ^ "Scientists use lipid nanoparticles to precisely target gene editing to the liver". EurekAlert!. 1 March 2021. Retrieved 2 March 2021.
  103. ^ Qiu, Min; Glass, Zachary; Chen, Jinjin; Haas, Mary; Jin, Xin; Zhao, Xuewei; Rui, Xuehui; Ye, Zhongfeng; Li, Yamin; Zhang, Feng; Xu, Qiaobing (9 March 2021). "Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3". Proceedings of the National Academy of Sciences. 118 (10): e2020401118. Bibcode: 2021PNAS..11820401Q. doi: 10.1073/pnas.2020401118. ISSN  0027-8424. PMC  7958351. PMID  33649229.
  104. ^ "Unique CRISPR gene therapy offers opioid-free chronic pain treatment". New Atlas. 11 March 2021. Retrieved 18 April 2021.
  105. ^ Moreno, Ana M.; Alemán, Fernando; Catroli, Glaucilene F.; Hunt, Matthew; Hu, Michael; Dailamy, Amir; Pla, Andrew; Woller, Sarah A.; Palmer, Nathan; Parekh, Udit; McDonald, Daniella; Roberts, Amanda J.; Goodwill, Vanessa; Dryden, Ian; Hevner, Robert F.; Delay, Lauriane; Santos, Gilson Gonçalves dos; Yaksh, Tony L.; Mali, Prashant (10 March 2021). "Long-lasting analgesia via targeted in situ repression of NaV1.7 in mice". Science Translational Medicine. 13 (584): eaay9056. doi: 10.1126/scitranslmed.aay9056. ISSN  1946-6234. PMC  8830379. PMID  33692134. S2CID  232170826.
  106. ^ Bowler, Jacinta (16 March 2021). "Microbes Unknown to Science Discovered on The International Space Station". ScienceAlert. Retrieved 16 March 2021.
  107. ^ Bijlani, Swati; Singh, Nitin K.; Eedara, V. V. Ramprasad; Podile, Appa Rao; Mason, Christopher E.; Wang, Clay C. C.; Venkateswaran, Kasthuri (2021). "Methylobacterium ajmalii sp. nov., Isolated From the International Space Station". Frontiers in Microbiology. 12: 639396. doi: 10.3389/fmicb.2021.639396. ISSN  1664-302X. PMC  8005752. PMID  33790880. Available under CC BY 4.0.
  108. ^ Lewis, Tanya. "Slovakia Offers a Lesson in How Rapid Testing Can Fight COVID". Scientific American. Retrieved 19 April 2021.
  109. ^ Pavelka, Martin; Van-Zandvoort, Kevin; Abbott, Sam; Sherratt, Katharine; Majdan, Marek; Group5, CMMID COVID-19 working; Analýz, Inštitút Zdravotných; Jarčuška, Pavol; Krajčí, Marek; Flasche, Stefan; Funk, Sebastian (23 March 2021). "The impact of population-wide rapid antigen testing on SARS-CoV-2 prevalence in Slovakia". Science. 372 (6542): 635–641. Bibcode: 2021Sci...372..635P. doi: 10.1126/science.abf9648. ISSN  0036-8075. PMC  8139426. PMID  33758017.{{ cite journal}}: CS1 maint: numeric names: authors list ( link)
  110. ^ "A third of global farmland at 'high' pesticide pollution risk". Retrieved 22 April 2021.
  111. ^ Tang, Fiona H. M.; Lenzen, Manfred; McBratney, Alexander; Maggi, Federico (April 2021). "Risk of pesticide pollution at the global scale". Nature Geoscience. 14 (4): 206–210. Bibcode: 2021NatGe..14..206T. doi: 10.1038/s41561-021-00712-5. ISSN  1752-0908.
  112. ^ "New, reversible CRISPR method can control gene expression while leaving underlying DNA sequence unchanged". Retrieved 10 May 2021.
  113. ^ Nuñez, James K.; Chen, Jin; Pommier, Greg C.; Cogan, J. Zachery; Replogle, Joseph M.; Adriaens, Carmen; Ramadoss, Gokul N.; Shi, Quanming; Hung, King L.; Samelson, Avi J.; Pogson, Angela N.; Kim, James Y. S.; Chung, Amanda; Leonetti, Manuel D.; Chang, Howard Y.; Kampmann, Martin; Bernstein, Bradley E.; Hovestadt, Volker; Gilbert, Luke A.; Weissman, Jonathan S. (29 April 2021). "Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing". Cell. 184 (9): 2503–2519.e17. doi: 10.1016/j.cell.2021.03.025. ISSN  0092-8674. PMC  8376083. PMID  33838111.
  114. ^ Subbaraman, Nidhi (15 April 2021). "First monkey–human embryos reignite debate over hybrid animals - The chimaeras lived up to 19 days — but some scientists question the need for such research". Nature. Retrieved 16 April 2021.
  115. ^ Wells, Sarah (15 April 2021). "Researchers Generate Human-Monkey Chimeric Embryos - Don't worry, there are not human-monkey babies — yet". Inverse. Retrieved 16 April 2021.
  116. ^ Tan, Tao; et al. (15 April 2021). "Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo". cell. 184 (8): 2020–2032.e14. doi: 10.1016/j.cell.2021.03.020. ISSN  0092-8674. PMID  33861963. S2CID  233247345.
  117. ^ "Malaria vaccine hailed as potential breakthrough". BBC News. April 23, 2021. Retrieved April 23, 2021.
  118. ^ Datoo, Mehreen S.; Natama, Magloire H.; Somé, Athanase; Traoré, Ousmane; Rouamba, Toussaint; Bellamy, Duncan; Yameogo, Prisca; Valia, Daniel; Tegneri, Moubarak; Ouedraogo, Florence; Soma, Rachidatou; Sawadogo, Seydou; Sorgho, Faizatou; Derra, Karim; Rouamba, Eli; Orindi, Benedict; Lopez, Fernando Ramos; Flaxman, Amy; Cappuccini, Federica; Kailath, Reshma; Elias, Sean; Mukhopadhyay, Ekta; Noe, Andres; Cairns, Matthew; Lawrie, Alison; Roberts, Rachel; Valéa, Innocent; Sorgho, Hermann; Williams, Nicola; Glenn, Gregory; Fries, Louis; Reimer, Jenny; Ewer, Katie J.; Shaligram, Umesh; Hill, Adrian V. S.; Tinto, Halidou (5 May 2021). "Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial". The Lancet. 397 (10287): 1809–1818. doi: 10.1016/S0140-6736(21)00943-0. ISSN  0140-6736. PMC  8121760. PMID  33964223. Available under CC BY 4.0.
  119. ^ "Scientists Gene-Hacked Monkeys to Fix Their Cholesterol". Futurism. Retrieved 13 June 2021.
  120. ^ Musunuru, Kiran; et al. (May 2021). "In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates". Nature. 593 (7859): 429–434. Bibcode: 2021Natur.593..429M. doi: 10.1038/s41586-021-03534-y. ISSN  1476-4687. PMID  34012082. S2CID  234790939. Retrieved 13 June 2021.
  121. ^ Zimmer, Carl (2021-05-24). "Scientists Partially Restored a Blind Man's Sight With New Gene Therapy". The New York Times. Retrieved 13 June 2021.
  122. ^ Sahel, José-Alain; Boulanger-Scemama, Elise; Pagot, Chloé; Arleo, Angelo; Galluppi, Francesco; Martel, Joseph N.; Esposti, Simona Degli; Delaux, Alexandre; de Saint Aubert, Jean-Baptiste; de Montleau, Caroline; Gutman, Emmanuel; Audo, Isabelle; Duebel, Jens; Picaud, Serge; Dalkara, Deniz; Blouin, Laure; Taiel, Magali; Roska, Botond (2021-05-24). "Partial recovery of visual function in a blind patient after optogenetic therapy". Nature Medicine. 27 (7): 1223–1229. doi: 10.1038/s41591-021-01351-4. ISSN  1546-170X. PMID  34031601.
  123. ^ "Resetting the biological clock by flipping a switch". Retrieved 14 June 2021.
  124. ^ Kolarski, Dušan; Miró-Vinyals, Carla; Sugiyama, Akiko; Srivastava, Ashutosh; Ono, Daisuke; Nagai, Yoshiko; Iida, Mui; Itami, Kenichiro; Tama, Florence; Szymanski, Wiktor; Hirota, Tsuyoshi; Feringa, Ben L. (2021-05-26). "Reversible modulation of circadian time with chronophotopharmacology". Nature Communications. 12 (1): 3164. Bibcode: 2021NatCo..12.3164K. doi: 10.1038/s41467-021-23301-x. ISSN  2041-1723. PMC  8155176. PMID  34039965. Available under CC BY 4.0.
  125. ^ Baylor College of Medicine (29 May 2021). "Biologists Construct a "Periodic Table" for Cell Nuclei – And Discover Something Strange, Baffling and Unexpected". ScioTechDaily. Retrieved 29 May 2021.
  126. ^ Hoencamp, Claire; et al. (28 May 2021). "3D genomics across the tree of life reveals condensin II as a determinant of architecture type". Science. 372 (6545): 984–989. doi: 10.1126/science.abe2218. PMC  8172041. PMID  34045355.
  127. ^ "'Vegan spider silk' provides sustainable alternative to single-use plastics". Retrieved 11 July 2021.
  128. ^ Kamada, Ayaka; Rodriguez-Garcia, Marc; Ruggeri, Francesco Simone; Shen, Yi; Levin, Aviad; Knowles, Tuomas P. J. (10 June 2021). "Controlled self-assembly of plant proteins into high-performance multifunctional nanostructured films". Nature Communications. 12 (1): 3529. Bibcode: 2021NatCo..12.3529K. doi: 10.1038/s41467-021-23813-6. ISSN  2041-1723. PMC  8192951. PMID  34112802.
  129. ^ KaiserJun. 26, Jocelyn (26 June 2021). "CRISPR injected into the blood treats a genetic disease for first time". Science | AAAS. Retrieved 11 July 2021.{{ cite news}}: CS1 maint: numeric names: authors list ( link)
  130. ^ Gillmore, Julian D.; Gane, Ed; Taubel, Jorg; Kao, Justin; Fontana, Marianna; Maitland, Michael L.; Seitzer, Jessica; O'Connell, Daniel; Walsh, Kathryn R.; Wood, Kristy; Phillips, Jonathan; Xu, Yuanxin; Amaral, Adam; Boyd, Adam P.; Cehelsky, Jeffrey E.; McKee, Mark D.; Schiermeier, Andrew; Harari, Olivier; Murphy, Andrew; Kyratsous, Christos A.; Zambrowicz, Brian; Soltys, Randy; Gutstein, David E.; Leonard, John; Sepp-Lorenzino, Laura; Lebwohl, David (26 June 2021). "CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis". New England Journal of Medicine. 385 (6): 493–502. doi: 10.1056/NEJMoa2107454. PMID  34215024. S2CID  235722446.
  131. ^ "Face masks that can diagnose COVID-19". Retrieved 11 July 2021.
  132. ^ Nguyen, Peter Q.; Soenksen, Luis R.; Donghia, Nina M.; Angenent-Mari, Nicolaas M.; de Puig, Helena; Huang, Ally; Lee, Rose; Slomovic, Shimyn; Galbersanini, Tommaso; Lansberry, Geoffrey; Sallum, Hani M.; Zhao, Evan M.; Niemi, James B.; Collins, James J. (28 June 2021). "Wearable materials with embedded synthetic biology sensors for biomolecule detection". Nature Biotechnology. 39 (11): 1366–1374. doi: 10.1038/s41587-021-00950-3. ISSN  1546-1696. PMID  34183860. S2CID  235673261.
  133. ^ "Growing food with air and solar power: More efficient than planting crops". Retrieved 11 July 2021.
  134. ^ Leger, Dorian; Matassa, Silvio; Noor, Elad; Shepon, Alon; Milo, Ron; Bar-Even, Arren (29 June 2021). "Photovoltaic-driven microbial protein production can use land and sunlight more efficiently than conventional crops". Proceedings of the National Academy of Sciences. 118 (26): e2015025118. Bibcode: 2021PNAS..11815025L. doi: 10.1073/pnas.2015025118. ISSN  0027-8424. PMC  8255800. PMID  34155098. S2CID  235595143.
  135. ^ Spary, Sara. "Cows' stomachs can break down plastic, study finds". CNN. Retrieved 14 August 2021.
  136. ^ Quartinello, Felice; Kremser, Klemens; Schoen, Herta; Tesei, Donatella; Ploszczanski, Leon; Nagler, Magdalena; Podmirseg, Sabine M.; Insam, Heribert; Piñar, Guadalupe; Sterflingler, Katja; Ribitsch, Doris; Guebitz, Georg M. (2021). "Together Is Better: The Rumen Microbial Community as Biological Toolbox for Degradation of Synthetic Polyesters". Frontiers in Bioengineering and Biotechnology. 9. doi: 10.3389/fbioe.2021.684459. ISSN  2296-4185.
  137. ^ "Scientists developing contraceptive that stops sperm in its tracks". ScienceDaily. Retrieved 21 September 2021.
  138. ^ Shrestha, Bhawana; Schaefer, Alison; Zhu, Yong; Saada, Jamal; Jacobs, Timothy M.; Chavez, Elizabeth C.; Omsted, Stuart S.; Cruz-Teran, Carlos A.; Vaca, Gabriela Baldeon; Vincent, Kathleen; Moench, Thomas R.; Lai, Samuel K. (11 August 2021). "Engineering sperm-binding IgG antibodies for the development of an effective nonhormonal female contraception". Science Translational Medicine. 13 (606). doi: 10.1126/scitranslmed.abd5219. PMC  8868023. PMID  34380769. S2CID  236979903.
  139. ^ "Probiotics help lab corals survive deadly heat stress". Science News. 13 August 2021. Retrieved 22 September 2021.
  140. ^ Santoro, Erika P.; Borges, Ricardo M.; Espinoza, Josh L.; Freire, Marcelo; Messias, Camila S. M. A.; Villela, Helena D. M.; Pereira, Leandro M.; Vilela, Caren L. S.; Rosado, João G.; Cardoso, Pedro M.; Rosado, Phillipe M.; Assis, Juliana M.; Duarte, Gustavo A. S.; Perna, Gabriela; Rosado, Alexandre S.; Macrae, Andrew; Dupont, Christopher L.; Nelson, Karen E.; Sweet, Michael J.; Voolstra, Christian R.; Peixoto, Raquel S. (August 2021). "Coral microbiome manipulation elicits metabolic and genetic restructuring to mitigate heat stress and evade mortality". Science Advances. 7 (33). Bibcode: 2021SciA....7.3088S. doi: 10.1126/sciadv.abg3088. hdl: 10754/670602. PMC  8363143. PMID  34389536.
  141. ^ "Japanese scientists produce first 3D-bioprinted, marbled Wagyu beef". New Atlas. 25 August 2021. Retrieved 21 September 2021.
  142. ^ Kang, Dong-Hee; Louis, Fiona; Liu, Hao; Shimoda, Hiroshi; Nishiyama, Yasutaka; Nozawa, Hajime; Kakitani, Makoto; Takagi, Daisuke; Kasa, Daijiro; Nagamori, Eiji; Irie, Shinji; Kitano, Shiro; Matsusaki, Michiya (24 August 2021). "Engineered whole cut meat-like tissue by the assembly of cell fibers using tendon-gel integrated bioprinting". Nature Communications. 12 (1): 5059. Bibcode: 2021NatCo..12.5059K. doi: 10.1038/s41467-021-25236-9. ISSN  2041-1723. PMC  8385070. PMID  34429413.
  143. ^ "Researchers develop an engineered 'mini' CRISPR genome editing system". Retrieved 18 October 2021.
  144. ^ Xu, Xiaoshu; Chemparathy, Augustine; Zeng, Leiping; Kempton, Hannah R.; Shang, Stephen; Nakamura, Muneaki; Qi, Lei S. (3 September 2021). "Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing". Molecular Cell. 81 (20): 4333–4345.e4. doi: 10.1016/j.molcel.2021.08.008. ISSN  1097-2765. PMID  34480847. S2CID  237417317.
  145. ^ a b Lavars, Nick (20 September 2021). "Lab-grown coffee cuts out the beans and deforestation". New Atlas. Retrieved 18 October 2021.
  146. ^ a b "Eco-friendly, lab-grown coffee is on the way, but it comes with a catch". The Guardian. 16 October 2021. Retrieved 21 November 2021.
  147. ^ "Sustainable coffee grown in Finland – | VTT News". 15 September 2021. Retrieved 18 October 2021.
  148. ^ "World-first artificial synthesis of starch from CO2 outperforms nature". New Atlas. 28 September 2021. Retrieved 18 October 2021.
  149. ^ Cai, Tao; Sun, Hongbing; Qiao, Jing; Zhu, Leilei; Zhang, Fan; Zhang, Jie; Tang, Zijing; Wei, Xinlei; Yang, Jiangang; Yuan, Qianqian; Wang, Wangyin; Yang, Xue; Chu, Huanyu; Wang, Qian; You, Chun; Ma, Hongwu; Sun, Yuanxia; Li, Yin; Li, Can; Jiang, Huifeng; Wang, Qinhong; Ma, Yanhe (24 September 2021). "Cell-free chemoenzymatic starch synthesis from carbon dioxide". Science. 373 (6562): 1523–1527. Bibcode: 2021Sci...373.1523C. doi: 10.1126/science.abh4049. PMID  34554807. S2CID  237615280.
  150. ^ Boonstra, Evert; de Kleijn, Roy; Colzato, Lorenza S.; Alkemade, Anneke; Forstmann, Birte U.; Nieuwenhuis, Sander (6 October 2015). "Neurotransmitters as food supplements: the effects of GABA on brain and behavior". Frontiers in Psychology. 6: 1520. doi: 10.3389/fpsyg.2015.01520. PMC  4594160. PMID  26500584.
  151. ^ "Tomato In Japan Is First CRISPR-Edited Food In The World To Go On Sale". IFLScience. Retrieved 18 October 2021.
  152. ^ Wang, Tian; Zhang, Hongyan; Zhu, Hongliang (15 June 2019). "CRISPR technology is revolutionizing the improvement of tomato and other fruit crops". Horticulture Research. 6 (1): 77. doi: 10.1038/s41438-019-0159-x. ISSN  2052-7276. PMC  6570646. PMID  31240102.
  153. ^ Yirka, Bob. "Reprogramming heart muscle cells to repair damage from heart attacks". Retrieved 20 October 2021.
  154. ^ Chen, Yanpu; Lüttmann, Felipe F.; Schoger, Eric; Schöler, Hans R.; Zelarayán, Laura C.; Kim, Kee-Pyo; Haigh, Jody J.; Kim, Johnny; Braun, Thomas (24 September 2021). "Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice". Science. 373 (6562): 1537–1540. Bibcode: 2021Sci...373.1537C. doi: 10.1126/science.abg5159. ISSN  0036-8075. PMID  34554778. S2CID  237617229.
  155. ^ "WHO endorses use of world's first malaria vaccine in Africa". The Guardian. 2021-10-08. Retrieved 2021-10-14.
  156. ^ "New, environmentally friendly method to extract and separate rare earth elements". Penn State. 2021-10-08. Retrieved 2021-10-14.
  157. ^ Dong, Ziye; Mattocks, Joseph A.; Deblonde, Gauthier J.-P.; Hu, Dehong; Jiao, Yongqin; Cotruvo, Joseph A.; Park, Dan M. (8 October 2021). "Bridging Hydrometallurgy and Biochemistry: A Protein-Based Process for Recovery and Separation of Rare Earth Elements". ACS Central Science. 7 (11): 1798–1808. doi: 10.1021/acscentsci.1c00724. ISSN  2374-7943. PMC  8614107. PMID  34841054.
  158. ^ "What does the first successful test of a pig-to-human kidney transplant mean?". Science News. 22 October 2021. Retrieved 15 November 2021.
  159. ^ "Progress in Xenotransplantation Opens Door to New Supply of Critically Needed Organs". NYU Langone News. Retrieved 15 November 2021.
  160. ^ "A chewing gum that could reduce SARS-CoV-2 transmission". University of Pennsylvania. Retrieved 13 December 2021.
  161. ^ Daniell, Henry; Nair, Smruti K.; Esmaeili, Nardana; Wakade, Geetanjali; Shahid, Naila; Ganesan, Prem Kumar; Islam, Md Reyazul; Shepley-McTaggart, Ariel; Feng, Sheng; Gary, Ebony N.; Ali, Ali R.; Nuth, Manunya; Cruz, Selene Nunez; Graham-Wooten, Jevon; Streatfield, Stephen J.; Montoya-Lopez, Ruben; Kaznica, Paul; Mawson, Margaret; Green, Brian J.; Ricciardi, Robert; Milone, Michael; Harty, Ronald N.; Wang, Ping; Weiner, David B.; Margulies, Kenneth B.; Collman, Ronald G. (10 November 2021). "Debulking SARS-CoV-2 in saliva using angiotensin converting enzyme 2 in chewing gum to decrease oral virus transmission and infection". Molecular Therapy. 30 (5): 1966–1978. doi: 10.1016/j.ymthe.2021.11.008. ISSN  1525-0016. PMC  8580552. PMID  34774754.
  162. ^ "Therapy used on mice may transform spinal injury treatments, say scientists". The Guardian. 11 November 2021. Retrieved 11 December 2021.
  163. ^ University. "'Dancing molecules' successfully repair severe spinal cord injuries in mice". Northwestern University. Retrieved 11 December 2021.
  164. ^ Álvarez, Z.; Kolberg-Edelbrock, A. N.; Sasselli, I. R.; Ortega, J. A.; Qiu, R.; Syrgiannis, Z.; Mirau, P. A.; Chen, F.; Chin, S. M.; Weigand, S.; Kiskinis, E.; Stupp, S. I. (12 November 2021). "Bioactive scaffolds with enhanced supramolecular motion promote recovery from spinal cord injury". Science. 374 (6569): 848–856. Bibcode: 2021Sci...374..848A. doi: 10.1126/science.abh3602. ISSN  0036-8075. PMC  8723833. PMID  34762454. S2CID  244039388.
  165. ^ "Antibiotic resistance outwitted by supercomputers". University of Portsmouth. Retrieved 13 December 2021.
  166. ^ König, Gerhard; Sokkar, Pandian; Pryk, Niclas; Heinrich, Sascha; Möller, David; Cimicata, Giuseppe; Matzov, Donna; Dietze, Pascal; Thiel, Walter; Bashan, Anat; Bandow, Julia Elisabeth; Zuegg, Johannes; Yonath, Ada; Schulz, Frank; Sanchez-Garcia, Elsa (16 November 2021). "Rational prioritization strategy allows the design of macrolide derivatives that overcome antibiotic resistance". Proceedings of the National Academy of Sciences. 118 (46): e2113632118. Bibcode: 2021PNAS..11813632K. doi: 10.1073/pnas.2113632118. ISSN  0027-8424. PMC  8609559. PMID  34750269.
  167. ^ Hathaway, Bill. "Novel Lyme vaccine shows promise". Yale University. Retrieved 13 December 2021. Compared to non-immunized guinea pigs, vaccinated animals exposed to infected ticks quickly developed redness at the tick bite site. None of the immunized animals developed Lyme disease if ticks were removed when redness developed. In contrast, about half of the control group became infected with B. burgdorferi after tick removal. When a single infected tick was attached to immunized guinea pigs and not removed, none of vaccinated animals were infected compared to 60 percent of control animals. However, protection waned in immunized guinea pigs if three ticks remained attached to the animal. Ticks in immunized animals were unable to feed aggressively and dislodged more quickly than those on guinea pigs in the control group.
  168. ^ Sajid, Andaleeb; Matias, Jaqueline; Arora, Gunjan; Kurokawa, Cheyne; DePonte, Kathleen; Tang, Xiaotian; Lynn, Geoffrey; Wu, Ming-Jie; Pal, Utpal; Strank, Norma Olivares; Pardi, Norbert; Narasimhan, Sukanya; Weissman, Drew; Fikrig, Erol (2021). "mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent". Science Translational Medicine. 13 (620): eabj9827. doi: 10.1126/scitranslmed.abj9827. PMID  34788080. S2CID  244375227.
  169. ^ Wipulasena, Aanya; Mashal, Mujib (7 December 2021). "Sri Lanka's Plunge Into Organic Farming Brings Disaster". The New York Times. Retrieved 13 December 2021.
  170. ^ "Sri Lanka ends farm chemical ban as organic drive fails". Retrieved 13 December 2021.
  171. ^ "Team Builds First Living Robots That Can Reproduce". November 29, 2021. Retrieved December 1, 2021.
  172. ^ Kriegman, Sam; Blackiston, Douglas; Levin, Michael; Bongard, Josh (7 December 2021). "Kinematic self-replication in reconfigurable organisms". Proceedings of the National Academy of Sciences. 118 (49): e2112672118. Bibcode: 2021PNAS..11812672K. doi: 10.1073/pnas.2112672118. ISSN  0027-8424. PMC  8670470. PMID  34845026. S2CID  244769761.
  173. ^ "Scientists claim big advance in using DNA to store data". 2 December 2021. Retrieved 3 December 2021.
  174. ^ "Stem cell-based treatment produces insulin in patients with Type 1 diabetes". 2 December 2021. Retrieved 6 December 2021.
  175. ^ Ramzy, Adam; Thompson, David M.; Ward-Hartstonge, Kirsten A.; Ivison, Sabine; Cook, Laura; Garcia, Rosa V.; Loyal, Jackson; Kim, Peter T. W.; Warnock, Garth L.; Levings, Megan K.; Kieffer, Timothy J. (2 December 2021). "Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes". Cell Stem Cell. 28 (12): 2047–2061.e5. doi: 10.1016/j.stem.2021.10.003. ISSN  1934-5909. PMID  34861146. S2CID  244855649.
  176. ^ Yirka, Bob. "A mass of human brain cells in a petri dish has been taught to play Pong". Retrieved 16 January 2022.
  177. ^ Kagan, Brett J.; Kitchen, Andy C.; Tran, Nhi T.; Parker, Bradyn J.; Bhat, Anjali; Rollo, Ben; Razi, Adeel; Friston, Karl J. (3 December 2021). "In vitro neurons learn and exhibit sentience when embodied in a simulated game-world": 2021.12.02.471005. doi: 10.1101/2021.12.02.471005. S2CID  244883160. {{ cite journal}}: Cite journal requires |journal= ( help)
  178. ^ "Japanese scientists develop glowing masks to detect coronavirus". Kyodo News+. Retrieved 16 January 2022.
  179. ^ Dicorato, Allessandra. "New prime editing system inserts entire genes in human cells". Broad Institute of MIT. Retrieved 16 January 2022.
  180. ^ Anzalone, Andrew V.; Gao, Xin D.; Podracky, Christopher J.; Nelson, Andrew T.; Koblan, Luke W.; Raguram, Aditya; Levy, Jonathan M.; Mercer, Jaron A. M.; Liu, David R. (9 December 2021). "Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing". Nature Biotechnology. 40 (5): 731–740. doi: 10.1038/s41587-021-01133-w. ISSN  1546-1696. PMC  9117393. PMID  34887556. S2CID  245012407.
  181. ^ "Experimental MRNA HIV Vaccine Safe, Shows Promise In Animals - ScienceMag". 9 December 2021. Retrieved 16 January 2022.
  182. ^ Zhang Peng; Elisabeth Narayanan; et al. (December 2021). "A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques". Nature Medicine. 27 (12): 2234–2245. doi: 10.1038/s41591-021-01574-5. ISSN  1546-170X. PMID  34887575. S2CID  245116317.
  183. ^ "Japanese scientists develop vaccine to eliminate cells behind aging". Japan Times. 12 December 2021. Archived from the original on 12 December 2021. Retrieved 12 December 2021.
  184. ^ "Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice". Nature Aging. 10 December 2021. Retrieved 12 December 2021.
  185. ^ Morens, David M.; Taubenberger, Jeffery K.; Fauci, Anthony S. (15 December 2021). "Universal Coronavirus Vaccines — An Urgent Need". New England Journal of Medicine. 386 (4): 297–299. doi: 10.1056/NEJMp2118468. PMID  34910863. S2CID  245219817.
  186. ^ "Chemists use DNA to build the world's tiniest antenna". University of Montreal. Retrieved 19 January 2022.
  187. ^ Harroun, Scott G.; Lauzon, Dominic; Ebert, Maximilian C. C. J. C.; Desrosiers, Arnaud; Wang, Xiaomeng; Vallée-Bélisle, Alexis (January 2022). "Monitoring protein conformational changes using fluorescent nanoantennas". Nature Methods. 19 (1): 71–80. doi: 10.1038/s41592-021-01355-5. ISSN  1548-7105. PMID  34969985. S2CID  245593311.
  188. ^ "Japan embraces CRISPR-edited fish". Nature Biotechnology. 40 (1): 10. 1 January 2022. doi: 10.1038/s41587-021-01197-8. PMID  34969964. S2CID  245593283. Retrieved 17 January 2022.
  189. ^ "Startup hopes genome-edited pufferfish will be a hit in 2022". The Japan Times. 5 January 2022. Retrieved 17 January 2022.
  190. ^ "Scientists vacuumed animal DNA out of thin air for the first time". Science News. 18 January 2022. Retrieved 29 January 2022.
  191. ^ Clare, Elizabeth L.; Economou, Chloe K.; Bennett, Frances J.; Dyer, Caitlin E.; Adams, Katherine; McRobie, Benjamin; Drinkwater, Rosie; Littlefair, Joanne E. (7 February 2022). "Measuring biodiversity from DNA in the air". Current Biology. 32 (3): 693–700.e5. doi: 10.1016/j.cub.2021.11.064. ISSN  0960-9822. PMID  34995488. S2CID  245772825.
  192. ^ Lynggaard, Christina; Bertelsen, Mads Frost; Jensen, Casper V.; Johnson, Matthew S.; Frøslev, Tobias Guldberg; Olsen, Morten Tange; Bohmann, Kristine (7 February 2022). "Airborne environmental DNA for terrestrial vertebrate community monitoring". Current Biology. 32 (3): 701–707.e5. doi: 10.1016/j.cub.2021.12.014. ISSN  0960-9822. PMC  8837273. PMID  34995490.
  193. ^ "Fastest DNA sequencing technique helps undiagnosed patients find answers in mere hours". Stanford. 12 January 2022. Archived from the original on 22 January 2022. Retrieved 23 January 2022.
  194. ^ Gorzynski, John E.; Goenka, Sneha D.; Shafin, Kishwar; Jensen, Tanner D.; Fisk, Dianna G.; Grove, Megan E.; Spiteri, Elizabeth; Pesout, Trevor; Monlong, Jean; Baid, Gunjan; Bernstein, Jonathan A.; Ceresnak, Scott; Chang, Pi-Chuan; Christle, Jeffrey W.; Chubb, Henry; Dalton, Karen P.; Dunn, Kyla; Garalde, Daniel R.; Guillory, Joseph; Knowles, Joshua W.; Kolesnikov, Alexey; Ma, Michael; Moscarello, Tia; Nattestad, Maria; Perez, Marco; Ruzhnikov, Maura R. Z.; Samadi, Mehrzad; Setia, Ankit; Wright, Chris; Wusthoff, Courtney J.; Xiong, Katherine; Zhu, Tong; Jain, Miten; Sedlazeck, Fritz J.; Carroll, Andrew; Paten, Benedict; Ashley, Euan A. (12 January 2022). "Ultrarapid Nanopore Genome Sequencing in a Critical Care Setting". New England Journal of Medicine. 386 (7): 700–702. doi: 10.1056/NEJMc2112090. PMID  35020984. S2CID  245907257.
  195. ^ Fuller, Carl W.; Padayatti, Pius S.; Abderrahim, Hadi; Adamiak, Lisa; Alagar, Nolan; Ananthapadmanabhan, Nagaraj; Baek, Jihye; Chinni, Sarat; Choi, Chulmin; Delaney, Kevin J.; Dubielzig, Rich; Frkanec, Julie; Garcia, Chris; Gardner, Calvin; Gebhardt, Daniel; Geiser, Tim; Gutierrez, Zachariah; Hall, Drew A.; Hodges, Andrew P.; Hou, Guangyuan; Jain, Sonal; Jones, Teresa; Lobaton, Raymond; Majzik, Zsolt; Marte, Allen; Mohan, Prateek; Mola, Paul; Mudondo, Paul; Mullinix, James; Nguyen, Thuan; Ollinger, Frederick; Orr, Sarah; Ouyang, Yuxuan; Pan, Paul; Park, Namseok; Porras, David; Prabhu, Keshav; Reese, Cassandra; Ruel, Travers; Sauerbrey, Trevor; Sawyer, Jaymie R.; Sinha, Prem; Tu, Jacky; Venkatesh, A. G.; VijayKumar, Sushmitha; Zheng, Le; Jin, Sungho; Tour, James M.; Church, George M.; Mola, Paul W.; Merriman, Barry (1 February 2022). "Molecular electronics sensors on a scalable semiconductor chip: A platform for single-molecule measurement of binding kinetics and enzyme activity". Proceedings of the National Academy of Sciences. 119 (5). Bibcode: 2022PNAS..11912812F. doi: 10.1073/pnas.2112812119. ISSN  0027-8424. PMC  8812571. PMID  35074874.
  196. ^ "DNA computer could tell you if your drinking water is contaminated". New Scientist. Retrieved 16 March 2022.
  197. ^ Jung, Jaeyoung K.; Archuleta, Chloé M.; Alam, Khalid K.; Lucks, Julius B. (17 February 2022). "Programming cell-free biosensors with DNA strand displacement circuits". Nature Chemical Biology. 18 (4): 385–393. doi: 10.1038/s41589-021-00962-9. ISSN  1552-4469. PMC  8964419. PMID  35177837.
  198. ^ "Tiny 'skyscrapers' help bacteria convert sunlight into electricity". University of Cambridge. Retrieved 19 April 2022.
  199. ^ Chen, Xiaolong; Lawrence, Joshua M.; Wey, Laura T.; Schertel, Lukas; Jing, Qingshen; Vignolini, Silvia; Howe, Christopher J.; Kar-Narayan, Sohini; Zhang, Jenny Z. (7 March 2022). "3D-printed hierarchical pillar array electrodes for high-performance semi-artificial photosynthesis". Nature Materials. 21 (7): 811–818. Bibcode: 2022NatMa..21..811C. doi: 10.1038/s41563-022-01205-5. ISSN  1476-4660. PMID  35256790. S2CID  247255146.
  200. ^ "Rice and maize yields boosted up to 10 per cent by CRISPR gene editing". New Scientist. Retrieved 19 April 2022.
  201. ^ Chen, Wenkang; Chen, Lu; Zhang, Xuan; Yang, Ning; Guo, Jianghua; Wang, Min; Ji, Shenghui; Zhao, Xiangyu; Yin, Pengfei; Cai, Lichun; Xu, Jing; Zhang, Lili; Han, Yingjia; Xiao, Yingni; Xu, Gen; Wang, Yuebin; Wang, Shuhui; Wu, Sheng; Yang, Fang; Jackson, David; Cheng, Jinkui; Chen, Saihua; Sun, Chuanqing; Qin, Feng; Tian, Feng; Fernie, Alisdair R.; Li, Jiansheng; Yan, Jianbing; Yang, Xiaohong (25 March 2022). "Convergent selection of a WD40 protein that enhances grain yield in maize and rice". Science. 375 (6587): eabg7985. doi: 10.1126/science.abg7985. PMID  35324310. S2CID  247677363.
  202. ^ "Gap-free human genome sequence completed for first time". BBC News. 2022-04-01. Retrieved 2022-04-03.
  203. ^ Sergey Nurk; et al. (2022). "The complete sequence of a human genome". Science. 376 (6588): 44–53. Bibcode: 2022Sci...376...44N. bioRxiv  10.1101/2021.05.26.445798. doi: 10.1126/science.abj6987. PMC  9186530. PMID  35357919. S2CID  247854936.
  204. ^ "Gene-edited tomatoes could soon be sold in England". BBC News. 24 May 2022. Retrieved 29 May 2022.
  205. ^ "Gene-edited tomatoes could be a new source of vitamin D". John Innes Centre. 23 May 2022. Retrieved 29 May 2022.
  206. ^ Li, Jie; Scarano, Aurelia; Gonzalez, Nestor Mora; D'Orso, Fabio; Yue, Yajuan; Nemeth, Krisztian; Saalbach, Gerhard; Hill, Lionel; de Oliveira Martins, Carlo; Moran, Rolando; Santino, Angelo; Martin, Cathie (June 2022). "Biofortified tomatoes provide a new route to vitamin D sufficiency". Nature Plants. 8 (6): 611–616. doi: 10.1038/s41477-022-01154-6. ISSN  2055-0278. PMC  9213236. PMID  35606499. S2CID  249014331.
  207. ^ Brahambhatt, Rupendra. "Science Scientists can now grow wood in a lab without cutting a single tree". Interesting Engineering. Retrieved 23 June 2022.
  208. ^ Beckwith, Ashley L.; Borenstein, Jeffrey T.; Velásquez-García, Luis F. (1 April 2022). "Physical, mechanical, and microstructural characterization of novel, 3D-printed, tunable, lab-grown plant materials generated from Zinnia elegans cell cultures". Materials Today. 54: 27–41. doi: 10.1016/j.mattod.2022.02.012. ISSN  1369-7021. S2CID  247300299.
  209. ^ "Scientists grew living human skin around a robotic finger". Science News. 9 June 2022. Retrieved 20 July 2022.
  210. ^ Kawai, Michio; Nie, Minghao; Oda, Haruka; Morimoto, Yuya; Takeuchi, Shoji (6 July 2022). "Living skin on a robot". Matter. 5 (7): 2190–2208. doi: 10.1016/j.matt.2022.05.019. ISSN  2590-2393.
  211. ^ Reynolds, Matt. "Scientists Are Trying to Grow Crops in the Dark". Wired. Retrieved 23 July 2022.
  212. ^ Hann, Elizabeth C.; Overa, Sean; Harland-Dunaway, Marcus; Narvaez, Andrés F.; Le, Dang N.; Orozco-Cárdenas, Martha L.; Jiao, Feng; Jinkerson, Robert E. (June 2022). "A hybrid inorganic–biological artificial photosynthesis system for energy-efficient food production". Nature Food. 3 (6): 461–471. doi: 10.1038/s43016-022-00530-x. ISSN  2662-1355. PMID  37118051. S2CID  250004816.
  213. ^ "Algae biopanel windows make power, oxygen and biomass, and suck up CO2". New Atlas. 11 July 2022. Retrieved 21 August 2022.
  214. ^ Paleja, Ameya (13 July 2022). "Algae-filled panels could generate oxygen and electricity while absorbing CO2". Retrieved 21 August 2022.
  215. ^ Talaei, Maryam; Mahdavinejad, Mohammadjavad; Azari, Rahman (1 March 2020). "Thermal and energy performance of algae bioreactive façades: A review". Journal of Building Engineering. 28: 101011. doi: 10.1016/j.jobe.2019.101011. ISSN  2352-7102. S2CID  210245691.
  216. ^ Wilkinson, Sara; Stoller, Paul; Ralph, Peter; Hamdorf, Brenton; Catana, Laila Navarro; Kuzava, Gabriela Santana (1 January 2017). "Exploring the Feasibility of Algae Building Technology in NSW". Procedia Engineering. 180: 1121–1130. doi: 10.1016/j.proeng.2017.04.272. ISSN  1877-7058.
  217. ^ "Biologists train AI to generate medicines and vaccines". University of Washington-Harborview Medical Center.
  218. ^ Wang, Jue; Lisanza, Sidney; Juergens, David; Tischer, Doug; Watson, Joseph L.; Castro, Karla M.; Ragotte, Robert; Saragovi, Amijai; Milles, Lukas F.; Baek, Minkyung; Anishchenko, Ivan; Yang, Wei; Hicks, Derrick R.; Expòsit, Marc; Schlichthaerle, Thomas; Chun, Jung-Ho; Dauparas, Justas; Bennett, Nathaniel; Wicky, Basile I. M.; Muenks, Andrew; DiMaio, Frank; Correia, Bruno; Ovchinnikov, Sergey; Baker, David (22 July 2022). "Scaffolding protein functional sites using deep learning" (PDF). Science. 377 (6604): 387–394. Bibcode: 2022Sci...377..387W. doi: 10.1126/science.abn2100. ISSN  0036-8075. PMC  9621694. PMID  35862514. S2CID  250953434.
  219. ^ "Scientists turned dead spiders into robots". Science News. 4 August 2022. Retrieved 21 August 2022.
  220. ^ Yap, Te Faye; Liu, Zhen; Rajappan, Anoop; Shimokusu, Trevor J.; Preston, Daniel J. (25 July 2022). "Necrobotics: Biotic Materials as Ready‐to‐Use Actuators". Advanced Science. 9 (29): 2201174. doi: 10.1002/advs.202201174. ISSN  2198-3844. PMC  9561765. PMID  35875913.
  221. ^ "DeepMind uncovers structure of 200m proteins in scientific leap forward". The Guardian. 2022-07-28. Retrieved 2022-07-28.
  222. ^ "AlphaFold reveals the structure of the protein universe". DeepMind. 2022-07-28. Retrieved 2022-07-28.
  223. ^ "Artificial neuron swaps dopamine with rat brain cells like a real one". New Scientist. Retrieved 16 September 2022.
  224. ^ Wang, Ting; Wang, Ming; Wang, Jianwu; Yang, Le; Ren, Xueyang; Song, Gang; Chen, Shisheng; Yuan, Yuehui; Liu, Ruiqing; Pan, Liang; Li, Zheng; Leow, Wan Ru; Luo, Yifei; Ji, Shaobo; Cui, Zequn; He, Ke; Zhang, Feilong; Lv, Fengting; Tian, Yuanyuan; Cai, Kaiyu; Yang, Bowen; Niu, Jingyi; Zou, Haochen; Liu, Songrui; Xu, Guoliang; Fan, Xing; Hu, Benhui; Loh, Xian Jun; Wang, Lianhui; Chen, Xiaodong (8 August 2022). "A chemically mediated artificial neuron". Nature Electronics. 5 (9): 586–595. doi: 10.1038/s41928-022-00803-0. hdl: 10356/163240. ISSN  2520-1131. S2CID  251464760.
  225. ^ "Food crops made 20% more efficient at harnessing sunlight". BBC News. 19 August 2022. Retrieved 21 August 2022.
  226. ^ Souza, Amanda P. De; et al. (2022). "Soybean photosynthesis and crop yield are improved by accelerating recovery from photoprotection". Science. 377 (6608): 851–854. Bibcode: 2022Sci...377..851D. doi: 10.1126/science.adc9831. PMID  35981033. S2CID  251670065.
  227. ^ "Scientists create world's first 'synthetic embryos'". The Guardian. 3 August 2022. Retrieved 16 September 2022.
  228. ^ Tarazi, Shadi; Aguilera-Castrejon, Alejandro; Joubran, Carine; Ghanem, Nadir; Ashouokhi, Shahd; Roncato, Francesco; Wildschutz, Emilie; Haddad, Montaser; Oldak, Bernardo; Gomez-Cesar, Elidet; Livnat, Nir; Viukov, Sergey; Lokshtanov, Dmitry; Naveh-Tassa, Segev; Rose, Max; Hanna, Suhair; Raanan, Calanit; Brenner, Ori; Kedmi, Merav; Keren-Shaul, Hadas; Lapidot, Tsvee; Maza, Itay; Novershtern, Noa; Hanna, Jacob H. (1 September 2022). "Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs". Cell. 185 (18): 3290–3306.e25. doi: 10.1016/j.cell.2022.07.028. ISSN  0092-8674. PMC  9439721. PMID  35988542.
  229. ^ Kotsiliti, Eleni (September 2022). "Synthetic mouse embryos". Nature Biotechnology. 40 (9): 1327. doi: 10.1038/s41587-022-01479-9. ISSN  1546-1696. PMID  36085513. S2CID  252181697.
  230. ^ Johnson, Carolyn Y. (2022-08-01). "Scientists create synthetic mouse embryos, a potential key to healing humans". Washington Post. ISSN  0190-8286. Retrieved 2023-09-16.
  231. ^ "Israeli Scientist Creates World's First Synthetic Embryo Using Just Stem Cells". Haaretz. Retrieved 2023-09-16.
  232. ^ Aguilera-Castrejon, Alejandro; Oldak, Bernardo; Shani, Tom; Ghanem, Nadir; Itzkovich, Chen; Slomovich, Sharon; Tarazi, Shadi; Bayerl, Jonathan; Chugaeva, Valeriya; Ayyash, Muneef; Ashouokhi, Shahd; Sheban, Daoud; Livnat, Nir; Lasman, Lior; Viukov, Sergey (May 2021). "Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis". Nature. 593 (7857): 119–124. Bibcode: 2021Natur.593..119A. doi: 10.1038/s41586-021-03416-3. ISSN  1476-4687. PMID  33731940. S2CID  232296340.
  233. ^ Kolata, Gina (2021-03-17). "Scientists Grow Mouse Embryos in a Mechanical Womb". The New York Times. ISSN  0362-4331. Retrieved 2023-09-16.
  234. ^ "Gentechnik soll kein Grund mehr für Verbote von Nutzpflanzen sein". DER STANDARD (in Austrian German). Retrieved 21 October 2022.
  235. ^ Gould, Fred; Amasino, Richard M.; Brossard, Dominique; Buell, C. Robin; Dixon, Richard A.; Falck-Zepeda, Jose B.; Gallo, Michael A.; Giller, Ken E.; Glenna, Leland L.; Griffin, Timothy; Magraw, Daniel; Mallory-Smith, Carol; Pixley, Kevin V.; Ransom, Elizabeth P.; Stelly, David M.; Stewart, C. Neal (2 September 2022). "Toward product-based regulation of crops". Science. 377 (6610): 1051–1053. Bibcode: 2022Sci...377.1051G. doi: 10.1126/science.abo3034. ISSN  0036-8075. PMID  36048940. S2CID  252008948.
  236. ^ "How cyborg cockroaches could be used to save people trapped under earthquake rubble". ABC News. 22 September 2022. Retrieved 20 October 2022.
  237. ^ Kakei, Yujiro; Katayama, Shumpei; Lee, Shinyoung; Takakuwa, Masahito; Furusawa, Kazuya; Umezu, Shinjiro; Sato, Hirotaka; Fukuda, Kenjiro; Someya, Takao (5 September 2022). "Integration of body-mounted ultrasoft organic solar cell on cyborg insects with intact mobility". npj Flexible Electronics. 6 (1): 1–9. doi: 10.1038/s41528-022-00207-2. ISSN  2397-4621.
  238. ^ "Bacteria and catalysts recycle waste plastic into useful chemicals". New Scientist. Retrieved 20 November 2022.
  239. ^ Sullivan, Kevin P.; Werner, Allison Z.; Ramirez, Kelsey J.; Ellis, Lucas D.; Bussard, Jeremy R.; Black, Brenna A.; Brandner, David G.; Bratti, Felicia; Buss, Bonnie L.; Dong, Xueming; Haugen, Stefan J.; Ingraham, Morgan A.; Konev, Mikhail O.; Michener, William E.; Miscall, Joel; Pardo, Isabel; Woodworth, Sean P.; Guss, Adam M.; Román-Leshkov, Yuriy; Stahl, Shannon S.; Beckham, Gregg T. (14 October 2022). "Mixed plastics waste valorization through tandem chemical oxidation and biological funneling". Science. 378 (6616): 207–211. Bibcode: 2022Sci...378..207S. doi: 10.1126/science.abo4626. hdl: 10261/281250. ISSN  0036-8075. PMID  36227984. S2CID  252897316.
  240. ^ Nahle, Zaher (2022). "A proof-of-concept study poised to remodel the drug development process". Frontiers in Medical Technology. 4. doi: 10.3389/fmedt.2022.1053588. PMC  9800902. PMID  36590153.
  241. ^ Ewart, Lorna; Apostolou, Athanasia; Briggs, Skyler A.; Carman, Christopher V.; Chaff, Jake T.; Heng, Anthony R.; Jadalannagari, Sushma; Janardhanan, Jeshina; Jang, Kyung-Jin; Joshipura, Sannidhi R.; Kadam, Mahika M.; Kanellias, Marianne; Kujala, Ville J.; Kulkarni, Gauri; Le, Christopher Y.; Lucchesi, Carolina; Manatakis, Dimitris V.; Maniar, Kairav K.; Quinn, Meaghan E.; Ravan, Joseph S.; Rizos, Ann Catherine; Sauld, John F. K.; Sliz, Josiah D.; Tien-Street, William; Trinidad, Dennis Ramos; Velez, James; Wendell, Max; Irrechukwu, Onyi; Mahalingaiah, Prathap Kumar; Ingber, Donald E.; Scannell, Jack W.; Levner, Daniel (6 December 2022). "Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology". Communications Medicine. 2 (1): 154. doi: 10.1038/s43856-022-00209-1. ISSN  2730-664X. PMC  9727064. PMID  36473994.
  242. ^ "Forschung an Krankheitserregern soll sicherer werden". Retrieved 17 January 2023.
  243. ^ Pannu, Jaspreet; Palmer, Megan J.; Cicero, Anita; Relman, David A.; Lipsitch, Marc; Inglesby, Tom (16 December 2022). "Strengthen oversight of risky research on pathogens". Science. 378 (6625): 1170–1172. Bibcode: 2022Sci...378.1170P. doi: 10.1126/science.adf6020. ISSN  0036-8075. PMID  36480598. S2CID  254998228.
  244. ^ "New 3D-printing ink could make cultured meat more cost-effective". EurekAlert!. 15 December 2022. Retrieved 16 December 2022.
  245. ^ Su, Lingshan; Jing, Linzhi; Zeng, Xianjian; Chen, Tong; Liu, Hang; Kong, Yan; Wang, Xiang; Yang, Xin; Fu, Caili; Sun, Jie; Huang, Dejian (January 2023). "3D‐Printed Prolamin Scaffolds for Cell‐Based Meat Culture". Advanced Materials. 35 (2): 2207397. Bibcode: 2023AdM....3507397S. doi: 10.1002/adma.202207397. PMID  36271729. S2CID  253063461.
  246. ^ "University of Maryland School of Medicine Faculty Scientists and Clinicians Perform Historic First Successful Transplant of Porcine Heart into Adult Human with End-Stage Heart Disease". University of Maryland Medical Center. 10 January 2022. Archived from the original on 10 January 2022. Retrieved 11 January 2022.
  247. ^ "Man gets genetically-modified pig heart in world-first transplant". BBC News. 10 January 2022. Archived from the original on 17 January 2022. Retrieved 11 January 2022.
  248. ^ "Phage therapies for superbug infections are being tested in Belgium". New Scientist. Retrieved 14 February 2022.
  249. ^ Eskenazi, Anaïs; Lood, Cédric; Wubbolts, Julia; Hites, Maya; Balarjishvili, Nana; Leshkasheli, Lika; Askilashvili, Lia; Kvachadze, Leila; van Noort, Vera; Wagemans, Jeroen; Jayankura, Marc; Chanishvili, Nina; de Boer, Mark; Nibbering, Peter; Kutateladze, Mzia; Lavigne, Rob; Merabishvili, Maya; Pirnay, Jean-Paul (18 January 2022). "Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae". Nature Communications. 13 (1): 302. Bibcode: 2022NatCo..13..302E. doi: 10.1038/s41467-021-27656-z. ISSN  2041-1723. PMC  8766457. PMID  35042848.
  250. ^ "Mit Viren gegen Bakterien - Bakteriophagen-Therapie als Hoffnung gegen multiresistente Keime". Deutschlandfunk (in German). Retrieved 14 February 2022.
  251. ^ Yirka, Bob. "Using a bacteriophage to successfully treat a patient infected with a drug-resistant bacteria". Retrieved 14 February 2022.
  252. ^ "Scientists regrow frog's lost leg". EurekAlert!. 26 January 2022. Archived from the original on 27 January 2022. Retrieved 27 January 2022.
  253. ^ Murugan, Nirosha J.; Vigran, Hannah J.; Miller, Kelsie A.; Golding, Annie; Pham, Quang L.; Sperry, Megan M.; Rasmussen-Ivey, Cody; Kane, Anna W.; Kaplan, David L.; Levin, Michael (January 2022). "Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis". Science Advances. 8 (4): eabj2164. Bibcode: 2022SciA....8.2164M. doi: 10.1126/sciadv.abj2164. PMC  8791464. PMID  35080969. S2CID  246296571.
  254. ^ "Detecting novel SARS-CoV-2 variants in New York City wastewater". University of Missouri. Retrieved 10 March 2022.
  255. ^ Smyth, Davida S.; Trujillo, Monica; Gregory, Devon A.; Cheung, Kristen; Gao, Anna; Graham, Maddie; Guan, Yue; Guldenpfennig, Caitlyn; Hoxie, Irene; Kannoly, Sherin; Kubota, Nanami; Lyddon, Terri D.; Markman, Michelle; Rushford, Clayton; San, Kaung Myat; Sompanya, Geena; Spagnolo, Fabrizio; Suarez, Reinier; Teixeiro, Emma; Daniels, Mark; Johnson, Marc C.; Dennehy, John J. (3 February 2022). "Tracking cryptic SARS-CoV-2 lineages detected in NYC wastewater". Nature Communications. 13 (1): 635. Bibcode: 2022NatCo..13..635S. doi: 10.1038/s41467-022-28246-3. ISSN  2041-1723. PMC  8813986. PMID  35115523.
  256. ^ "Paralysed man with severed spine walks thanks to implant". BBC News. 7 February 2022. Retrieved 10 March 2022.
  257. ^ Rowald, Andreas; Komi, Salif; Demesmaeker, Robin; et al. (February 2022). "Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis". Nature Medicine. 28 (2): 260–271. doi: 10.1038/s41591-021-01663-5. ISSN  1546-170X. PMID  35132264. S2CID  246651655.
  258. ^ "In world-first, researchers engineer human spinal cord implants for treating paralysis". Tel-Aviv University. Retrieved 10 March 2022.
  259. ^ "Engineered spinal cord implants restore movement to paralysed mice". Physics World. 23 February 2022. Retrieved 10 March 2022.
  260. ^ Wertheim, Lior; Edri, Reuven; Goldshmit, Yona; Kagan, Tomer; Noor, Nadav; Ruban, Angela; Shapira, Assaf; Gat‐Viks, Irit; Assaf, Yaniv; Dvir, Tal (7 February 2022). "Regenerating the Injured Spinal Cord at the Chronic Phase by Engineered iPSCs‐Derived 3D Neuronal Networks". Advanced Science. 9 (11): 2105694. doi: 10.1002/advs.202105694. PMC  9008789. PMID  35128819.
  261. ^ "Comprehensive Cancer Treatment Technique Developed by IBS and UNIST". Businesskorea. 24 February 2022. Retrieved 25 February 2022.
  262. ^ "Scientists develop a new platform technology for personalized cancer therapy". EurekAlert!. 21 February 2022. Retrieved 25 February 2022.
  263. ^ Kwon, Taejoon; Ra, Jae Sun; Lee, Soyoung; Baek, In-Joon; Khim, Keon Woo; Lee, Eun A; Song, Eun Kyung; Otarbayev, Daniyar; Jung, Woojae; Park, Yong Hwan; Wie, Minwoo; Bae, Juyoung; Cheng, Himchan; Park, Jun Hong; Kim, Namwoo; Seo, Yuri; Yun, Seongmin; Kim, Ha Eun; Moon, Hyo Eun; Paek, Sun Ha; Park, Tae Joo; Park, Young Un; Rhee, Hwanseok; Choi, Jang Hyun; Cho, Seung Woo; Myung, Kyungjae (March 2022). "Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9". Proceedings of the National Academy of Sciences. 119 (9): e2103532119. Bibcode: 2022PNAS..11903532K. doi: 10.1073/pnas.2103532119. PMC  8892319. PMID  35217600.
  264. ^ Williams, Sarah. "Neuroscientists expand CRISPR toolkit with new, compact Cas7-11 enzyme". Massachusetts Institute of Technology. Retrieved 22 June 2022.
  265. ^ Kato, Kazuki; Zhou, Wenyuan; Okazaki, Sae; Isayama, Yukari; Nishizawa, Tomohiro; Gootenberg, Jonathan S.; Abudayyeh, Omar O.; Nishimasu, Hiroshi (May 2022). "Structure and engineering of the type III-E CRISPR-Cas7-11 effector complex". Cell. 185 (13): 2324–2337.e16. doi: 10.1016/j.cell.2022.05.003. PMID  35643083. S2CID  249103058.
  266. ^ Özcan, Ahsen; Krajeski, Rohan; Ioannidi, Eleonora; Lee, Brennan; Gardner, Apolonia; Makarova, Kira S.; Koonin, Eugene V.; Abudayyeh, Omar O.; Gootenberg, Jonathan S. (September 2021). "Programmable RNA targeting with the single-protein CRISPR effector Cas7-11". Nature. 597 (7878): 720–725. Bibcode: 2021Natur.597..720O. doi: 10.1038/s41586-021-03886-5. ISSN  1476-4687. PMID  34489594. S2CID  237432753.
  267. ^ "Tiny robotic crab is smallest-ever remote-controlled walking robot". Northwestern University. 25 May 2022. Retrieved 27 May 2022.
  268. ^ Han, Mengdi; Guo, Xiaogang; Chen, Xuexian; Liang, Cunman; Zhao, Hangbo; Zhang, Qihui; Bai, Wubin; Zhang, Fan; Wei, Heming; Wu, Changsheng; Cui, Qinghong; Yao, Shenglian; Sun, Bohan; Yang, Yiyuan; Yang, Quansan; Ma, Yuhang; Xue, Zhaoguo; Kwak, Jean Won; Jin, Tianqi; Tu, Qing; Song, Enming; Tian, Ziao; Mei, Yongfeng; Fang, Daining; Zhang, Haixia; Huang, Yonggang; Zhang, Yihui; Rogers, John A. (25 May 2022). "Submillimeter-scale multimaterial terrestrial robots". Science Robotics. 7 (66): eabn0602. doi: 10.1126/scirobotics.abn0602. ISSN  2470-9476. PMID  35613299. S2CID  249064902.
  269. ^ "Transplant success: Liver survives out of body for days". BBC News. 31 May 2022. Retrieved 24 June 2022.
  270. ^ Clavien, Pierre-Alain; Dutkowski, Philipp; Mueller, Matteo; Eshmuminov, Dilmurodjon; Bautista Borrego, Lucia; Weber, Achim; Muellhaupt, Beat; Sousa Da Silva, Richard X.; Burg, Brian R.; Rudolf von Rohr, Philipp; Schuler, Martin J.; Becker, Dustin; Hefti, Max; Tibbitt, Mark W. (31 May 2022). "Transplantation of a human liver following 3 days of ex situ normothermic preservation". Nature Biotechnology. 40 (11): 1610–1616. doi: 10.1038/s41587-022-01354-7. ISSN  1546-1696. PMID  35641829. S2CID  249234907.
  271. ^ "New cryoprotectant chemicals could preserve organs without ice damage". New Atlas. 22 June 2022. Retrieved 24 June 2022.
  272. ^ Bryant, Saffron J.; Awad, Miyah N.; Elbourne, Aaron; Christofferson, Andrew J.; Martin, Andrew V.; Meftahi, Nastaran; Drummond, Calum J.; Greaves, Tamar L.; Bryant, Gary (22 June 2022). "Deep eutectic solvents as cryoprotective agents for mammalian cells". Journal of Materials Chemistry B. 10 (24): 4546–4560. doi: 10.1039/D2TB00573E. ISSN  2050-7518. PMID  35670530.
  273. ^ "A Multicenter, Single Arm, Prospective, Open-Label, Staged Study of the Safety and Efficacy of the AuriNovo Construct for Auricular Reconstruction in Subjects With Unilateral Microtia". 15 October 2021. Retrieved 19 July 2022.
  274. ^ Rabin, Roni Caryn (2 June 2022). "Doctors Transplant Ear of Human Cells, Made by 3-D Printer". The New York Times. Retrieved 19 July 2022.
  275. ^ "Scientists harness light therapy to target and kill cancer cells in world first". The Guardian. 17 June 2022. Retrieved 21 June 2022.
  276. ^ Mączyńska, Justyna; Raes, Florian; Da Pieve, Chiara; Turnock, Stephen; Boult, Jessica K. R.; Hoebart, Julia; Niedbala, Marcin; Robinson, Simon P.; Harrington, Kevin J.; Kaspera, Wojciech; Kramer-Marek, Gabriela (21 January 2022). "Triggering anti-GBM immune response with EGFR-mediated photoimmunotherapy". BMC Medicine. 20 (1): 16. doi: 10.1186/s12916-021-02213-z. ISSN  1741-7015. PMC  8780306. PMID  35057796.
  277. ^ "New COVID-19 boosters could contain bits of the omicron variant". Science News. 30 June 2022. Retrieved 19 July 2022.
  278. ^ "'Softer' form of CRISPR may edit genes more accurately". New Scientist. Retrieved 21 August 2022.
  279. ^ Roy, Sitara; Juste, Sara Sanz; Sneider, Marketta; Auradkar, Ankush; Klanseck, Carissa; Li, Zhiqian; Julio, Alison Henrique Ferreira; del Amo, Victor Lopez; Bier, Ethan; Guichard, Annabel (July 2022). "Cas9/Nickase-induced allelic conversion by homologous chromosome-templated repair in Drosophila somatic cells". Science Advances. 8 (26): eabo0721. Bibcode: 2022SciA....8O.721R. doi: 10.1126/sciadv.abo0721. ISSN  2375-2548. PMID  35776792.
  280. ^ "UK scientists take 'promising' step towards single Covid and cold vaccine". The Guardian. 2022-07-27. Retrieved 2022-07-28.
  281. ^ Ng, Kevin W.; Faulkner, Nikhil; Finsterbusch, Katja; Wu, Mary; Harvey, Ruth; Hussain, Saira; Greco, Maria; Liu, Yafei; Kjaer, Svend; Swanton, Charles; Gandhi, Sonia; Beale, Rupert; Gamblin, Steve J.; Cherepanov, Peter; McCauley, John; Daniels, Rodney; Howell, Michael; Arase, Hisashi; Wack, Andreas; Bauer, David L.V.; Kassiotis, George (27 July 2022). "SARS-CoV-2 S2–targeted vaccination elicits broadly neutralizing antibodies". Science Translational Medicine. 14 (655): eabn3715. doi: 10.1126/scitranslmed.abn3715. ISSN  1946-6234. PMID  35895836.
  282. ^ a b c "Pig organs partially revived hour after death". BBC News. 3 August 2022. Retrieved 15 September 2022.
  283. ^ Andrijevic, David; Vrselja, Zvonimir; Lysyy, Taras; Zhang, Shupei; Skarica, Mario; Spajic, Ana; Dellal, David; Thorn, Stephanie L.; Duckrow, Robert B.; Ma, Shaojie; Duy, Phan Q.; Isiktas, Atagun U.; Liang, Dan; Li, Mingfeng; Kim, Suel-Kee; Daniele, Stefano G.; Banu, Khadija; Perincheri, Sudhir; Menon, Madhav C.; Huttner, Anita; Sheth, Kevin N.; Gobeske, Kevin T.; Tietjen, Gregory T.; Zaveri, Hitten P.; Latham, Stephen R.; Sinusas, Albert J.; Sestan, Nenad (August 2022). "Cellular recovery after prolonged warm ischaemia of the whole body". Nature. 608 (7922): 405–412. Bibcode: 2022Natur.608..405A. doi: 10.1038/s41586-022-05016-1. ISSN  1476-4687. PMC  9518831. PMID  35922506. S2CID  251316299.
  284. ^ Vrselja, Zvonimir; Daniele, Stefano G.; Silbereis, John; Talpo, Francesca; Morozov, Yury M.; Sousa, André M. M.; Tanaka, Brian S.; Skarica, Mario; Pletikos, Mihovil; Kaur, Navjot; Zhuang, Zhen W.; Liu, Zhao; Alkawadri, Rafeed; Sinusas, Albert J.; Latham, Stephen R.; Waxman, Stephen G.; Sestan, Nenad (April 2019). "Restoration of brain circulation and cellular functions hours post-mortem". Nature. 568 (7752): 336–343. Bibcode: 2019Natur.568..336V. doi: 10.1038/s41586-019-1099-1. ISSN  1476-4687. PMC  6844189. PMID  30996318.
  285. ^ "Hydrogel that outperforms cartilage could be in human knees in 2023". New Atlas. 15 August 2022. Retrieved 16 September 2022.
  286. ^ Zhao, Jiacheng; Tong, Huayu; Kirillova, Alina; Koshut, William J.; Malek, Andrew; Brigham, Natasha C.; Becker, Matthew L.; Gall, Ken; Wiley, Benjamin J. (14 August 2022). "A Synthetic Hydrogel Composite with a Strength and Wear Resistance Greater than Cartilage". Advanced Functional Materials. 32 (41). doi: 10.1002/adfm.202205662. S2CID  251417385. Retrieved 4 August 2022.
  287. ^ "Bioengineered cornea can restore sight to the blind and visually impaired". Linköping University. 11 August 2022. Retrieved 14 August 2022.
  288. ^ Rafat, Mehrdad; Jabbarvand, Mahmoud; Sharma, Namrata; Xeroudaki, Maria; Tabe, Shideh; Omrani, Raha; Thangavelu, Muthukumar; Mukwaya, Anthony; Fagerholm, Per; Lennikov, Anton; Askarizadeh, Farshad; Lagali, Neil (11 August 2022). "Bioengineered corneal tissue for minimally invasive vision restoration in advanced keratoconus in two clinical cohorts". Nature Biotechnology. 41 (1): 70–81. doi: 10.1038/s41587-022-01408-w. ISSN  1546-1696. PMC  9849136. PMID  35953672.
  289. ^ "UBC researchers discover 'weak spot' across major COVID-19 variants". EurekAlert!. 18 August 2022. Retrieved 19 August 2022.
  290. ^ Mannar, Dhiraj; Saville, James W.; Sun, Zehua; Zhu, Xing; Marti, Michelle M.; Srivastava, Shanti S.; Berezuk, Alison M.; Zhou, Steven; Tuttle, Katharine S.; Sobolewski, Michele D.; Kim, Andrew; Treat, Benjamin R.; Da Silva Castanha, Priscila Mayrelle; Jacobs, Jana L.; Barratt-Boyes, Simon M.; Mellors, John W.; Dimitrov, Dimiter S.; Li, Wei; Subramaniam, Sriram (18 August 2022). "SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization". Nature Communications. 13 (1): 4696. Bibcode: 2022NatCo..13.4696M. doi: 10.1038/s41467-022-32262-8. PMC  9388680. PMID  35982054.
  291. ^ "New Antibody Neutralizes All Known COVID-19 Variants". IFLScience. Retrieved 16 September 2022.
  292. ^ Luo, Sai; Zhang, Jun; Kreutzberger, Alex J.B.; Eaton, Amanda; Edwards, Robert J.; Jing, Changbin; Dai, Hai-Qiang; Sempowski, Gregory D.; Cronin, Kenneth; Parks, Robert; Ye, Adam Yongxin; Mansouri, Katayoun; Barr, Maggie; Pishesha, Novalia; Williams, Aimee Chapdelaine; Vieira Francisco, Lucas; Saminathan, Anand; Peng, Hanqin; Batra, Himanshu; Bellusci, Lorenza; Khurana, Surender; Alam, S. Munir; Montefiori, David C.; Saunders, Kevin O.; Tian, Ming; Ploegh, Hidde; Kirchhausen, Tom; Chen, Bing; Haynes, Barton F.; Alt, Frederick W. (11 August 2022). "An Antibody from Single Human VH-rearranging Mouse Neutralizes All SARS-CoV-2 Variants Through BA.5 by Inhibiting Membrane Fusion". Science Immunology. 7 (76): eadd5446. doi: 10.1126/sciimmunol.add5446. ISSN  2470-9468. PMC  9407951. PMID  35951767.
  293. ^ "World's first mini organ transportation to a patient with ulcerative colitis". Tokyo Medical and Dental University via Retrieved 18 September 2022.
  294. ^ Watanabe, Satoshi; Kobayashi, Sakurako; Ogasawara, Nobuhiko; Okamoto, Ryuichi; Nakamura, Tetsuya; Watanabe, Mamoru; Jensen, Kim B.; Yui, Shiro (March 2022). "Transplantation of intestinal organoids into a mouse model of colitis". Nature Protocols. 17 (3): 649–671. doi: 10.1038/s41596-021-00658-3. ISSN  1750-2799. PMID  35110738. S2CID  246488596.
  295. ^ Williams, Sarah. "A cellular engineering breakthrough: High-yield CRISPR without viral vectors". Gladstone Institutes. Retrieved 15 September 2022.
  296. ^ Shy, Brian R.; Vykunta, Vivasvan S.; Ha, Alvin; Talbot, Alexis; Roth, Theodore L.; Nguyen, David N.; Pfeifer, Wolfgang G.; Chen, Yan Yi; Blaeschke, Franziska; Shifrut, Eric; Vedova, Shane; Mamedov, Murad R.; Chung, Jing-Yi Jing; Li, Hong; Yu, Ruby; Wu, David; Wolf, Jeffrey; Martin, Thomas G.; Castro, Carlos E.; Ye, Lumeng; Esensten, Jonathan H.; Eyquem, Justin; Marson, Alexander (25 August 2022). "High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails". Nature Biotechnology. 41 (4): 521–531. doi: 10.1038/s41587-022-01418-8. ISSN  1546-1696. PMC  10065198. PMID  36008610. S2CID  251843150.
  297. ^ a b de Jonge, Eline F.; Peterse, Céline M.; Koelewijn, Jaap M.; van der Drift, Anne-Merel R.; van der Beek, Rudolf F. H. J.; Nagelkerke, Erwin; Lodder, Willemijn J. (15 December 2022). "The detection of monkeypox virus DNA in wastewater samples in the Netherlands". Science of the Total Environment. 852: 158265. Bibcode: 2022ScTEn.852o8265D. doi: 10.1016/j.scitotenv.2022.158265. ISSN  0048-9697. PMC  9558568. PMID  36057309.
  298. ^ "Wastewater surveillance becomes more targeted in search for poliovirus, monkeypox and coronavirus". CBS News. Retrieved 18 September 2022.
  299. ^ Payne, Aaron; Kreidler, Mark (8 August 2022). "COVID sewage surveillance labs join the hunt for monkeypox". WOUB Public Media. Retrieved 18 September 2022.
  300. ^ "New malaria vaccine is world-changing, say scientists". BBC News. 8 September 2022. Retrieved 8 September 2022.
  301. ^ Datoo, M. S.; et al. (7 September 2022). "Efficacy and immunogenicity of R21/Matrix-M vaccine against clinical malaria after 2 years' follow-up in children in Burkina Faso: a phase 1/2b randomised controlled trial". The Lancet. Infectious Diseases. 22 (12): 1728–1736. doi: 10.1016/S1473-3099(22)00442-X. PMID  36087586. S2CID  252149462. Retrieved 8 September 2022.
  302. ^ "New antiviral therapy may block COVID-19 transmission". Gladstone Institutes via Retrieved 21 October 2022.
  303. ^ Chaturvedi, Sonali; Beutler, Nathan; Vasen, Gustavo; Pablo, Michael; Chen, Xinyue; Calia, Giuliana; Buie, Lauren; Rodick, Robert; Smith, Davey; Rogers, Thomas; Weinberger, Leor S. (27 September 2022). "A single-administration therapeutic interfering particle reduces SARS-CoV-2 viral shedding and pathogenesis in hamsters". Proceedings of the National Academy of Sciences. 119 (39): e2204624119. Bibcode: 2022PNAS..11904624C. doi: 10.1073/pnas.2204624119. ISSN  0027-8424. PMC  9522362. PMID  36074824.
  304. ^ "Two inhaled covid vaccines have been approved—but we don't know yet how good they are". MIT Technology Review. Retrieved 21 October 2022.
  305. ^ a b Waltz, Emily (7 September 2022). "China and India approve nasal COVID vaccines — are they a game changer?". Nature. 609 (7927): 450. Bibcode: 2022Natur.609..450W. doi: 10.1038/d41586-022-02851-0. PMID  36071228. S2CID  252121594.
  306. ^ Dhama, Kuldeep; Dhawan, Manish; Tiwari, Ruchi; Emran, Talha Bin; Mitra, Saikat; Rabaan, Ali A.; Alhumaid, Saad; Alawi, Zainab Al; Al Mutair, Abbas (30 November 2022). "COVID-19 intranasal vaccines: current progress, advantages, prospects, and challenges". Human Vaccines & Immunotherapeutics. 18 (5): 2045853. doi: 10.1080/21645515.2022.2045853. ISSN  2164-5515. PMC  8935456. PMID  35258416.
  307. ^ "Algae micromotors join the ranks for targeted drug delivery". Chemical & Engineering News. Retrieved 19 October 2022.
  308. ^ Zhang, Fangyu; Zhuang, Jia; Li, Zhengxing; Gong, Hua; de Ávila, Berta Esteban-Fernández; Duan, Yaou; Zhang, Qiangzhe; Zhou, Jiarong; Yin, Lu; Karshalev, Emil; Gao, Weiwei; Nizet, Victor; Fang, Ronnie H.; Zhang, Liangfang; Wang, Joseph (22 September 2022). "Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia". Nature Materials. 21 (11): 1324–1332. Bibcode: 2022NatMa..21.1324Z. doi: 10.1038/s41563-022-01360-9. ISSN  1476-4660. PMC  9633541. PMID  36138145.
  309. ^ Zhang, Fangyu; Li, Zhengxing; Duan, Yaou; Abbas, Amal; Mundaca-Uribe, Rodolfo; Yin, Lu; Luan, Hao; Gao, Weiwei; Fang, Ronnie H.; Zhang, Liangfang; Wang, Joseph (28 September 2022). "Gastrointestinal tract drug delivery using algae motors embedded in a degradable capsule". Science Robotics. 7 (70): eabo4160. doi: 10.1126/scirobotics.abo4160. ISSN  2470-9476. PMC  9884493. PMID  36170380. S2CID  252598190.
  310. ^ "This robotic pill clears mucus from the gut to deliver meds". Science News. 28 September 2022. Retrieved 19 October 2022.
  311. ^ Srinivasan, Shriya S.; Alshareef, Amro; Hwang, Alexandria V.; Kang, Ziliang; Kuosmanen, Johannes; Ishida, Keiko; Jenkins, Joshua; Liu, Sabrina; Madani, Wiam Abdalla Mohammed; Lennerz, Jochen; Hayward, Alison; Morimoto, Josh; Fitzgerald, Nina; Langer, Robert; Traverso, Giovanni (28 September 2022). "RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract". Science Robotics. 7 (70): eabp9066. doi: 10.1126/scirobotics.abp9066. ISSN  2470-9476. PMC  10034646. PMID  36170378. S2CID  252597856.
  312. ^ Schmidt, Christine K.; Medina-Sánchez, Mariana; Edmondson, Richard J.; Schmidt, Oliver G. (5 November 2020). "Engineering microrobots for targeted cancer therapies from a medical perspective". Nature Communications. 11 (1): 5618. Bibcode: 2020NatCo..11.5618S. doi: 10.1038/s41467-020-19322-7. ISSN  2041-1723. PMC  7645678. PMID  33154372.
  313. ^ Thompson, Joanna. "These tiny magnetic robots can infiltrate tumors — and maybe destroy cancer". Inverse. Retrieved 21 November 2022.
  314. ^ Gwisai, T.; Mirkhani, N.; Christiansen, M. G.; Nguyen, T. T.; Ling, V.; Schuerle, S. (26 October 2022). "Magnetic torque–driven living microrobots for increased tumor infiltration". Science Robotics. 7 (71): eabo0665. bioRxiv  10.1101/2022.01.03.473989. doi: 10.1126/scirobotics.abo0665. ISSN  2470-9476. PMID  36288270. S2CID  253160428.
  315. ^ "Lab-grown blood given to people in world-first clinical trial". BBC News. 7 November 2022. Retrieved 7 November 2022.
  316. ^ "First ever clinical trial of laboratory grown red blood cells being transfused into another person underway". University of Bristol. 7 November 2022. Retrieved 7 November 2022.
  317. ^ McDonnell, Sarah. "New CRISPR-based tool inserts large DNA sequences at desired sites in cells". Massachusetts Institute of Technology via Retrieved 18 December 2022.
  318. ^ Yarnall, Matthew T. N.; Ioannidi, Eleonora I.; Schmitt-Ulms, Cian; Krajeski, Rohan N.; Lim, Justin; Villiger, Lukas; Zhou, Wenyuan; Jiang, Kaiyi; Garushyants, Sofya K.; Roberts, Nathaniel; Zhang, Liyang; Vakulskas, Christopher A.; Walker, John A.; Kadina, Anastasia P.; Zepeda, Adrianna E.; Holden, Kevin; Ma, Hong; Xie, Jun; Gao, Guangping; Foquet, Lander; Bial, Greg; Donnelly, Sara K.; Miyata, Yoshinari; Radiloff, Daniel R.; Henderson, Jordana M.; Ujita, Andrew; Abudayyeh, Omar O.; Gootenberg, Jonathan S. (24 November 2022). "Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases". Nature Biotechnology. 41 (4): 500–512. bioRxiv  10.1101/2021.11.01.466786. doi: 10.1038/s41587-022-01527-4. ISSN  1546-1696. PMC  10257351. PMID  36424489. S2CID  253879386.
  319. ^ Grimes, Brittney (8 December 2022). "A novel blood test can detect Alzheimer's disease early". Interesting Engineering. Retrieved 17 January 2023.
  320. ^ Shea, Dylan; Colasurdo, Elizabeth; Smith, Alec; Paschall, Courtnie; Jayadev, Suman; Keene, C. Dirk; Galasko, Douglas; Ko, Andrew; Li, Ge; Peskind, Elaine; Daggett, Valerie (13 December 2022). "SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers". Proceedings of the National Academy of Sciences. 119 (50): e2213157119. Bibcode: 2022PNAS..11913157S. doi: 10.1073/pnas.2213157119. ISSN  0027-8424. PMC  9897489. PMID  36490316. S2CID  254518036.
  321. ^ "Scientists develop blood test for Alzheimer's disease". The Guardian. 28 December 2022. Retrieved 18 January 2023.
  322. ^ Gonzalez-Ortiz, Fernando; Turton, Michael; Kac, Przemysław R; Smirnov, Denis; Premi, Enrico; Ghidoni, Roberta; Benussi, Luisa; Cantoni, Valentina; Saraceno, Claudia; Rivolta, Jasmine; Ashton, Nicholas J; Borroni, Barbara; Galasko, Douglas; Harrison, Peter; Zetterberg, Henrik; Blennow, Kaj; Karikari, Thomas K (27 December 2022). "Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration". Brain. 146 (3): 1152–1165. doi: 10.1093/brain/awac407. PMC  9976981. PMID  36572122.
  323. ^ Firtina, Nergis (1 February 2023). "Semi-living 'cyborg cells' could treat cancer, suggests new study". Interesting Engineering. Archived from the original on 15 February 2023. Retrieved 15 February 2023.
  324. ^ Contreras‐Llano, Luis E.; Liu, Yu‐Han; Henson, Tanner; Meyer, Conary C.; Baghdasaryan, Ofelya; Khan, Shahid; Lin, Chi‐Long; Wang, Aijun; Hu, Che‐Ming J.; Tan, Cheemeng (11 January 2023). "Engineering Cyborg Bacteria Through Intracellular Hydrogelation". Advanced Science. 10 (9): 2204175. doi: 10.1002/advs.202204175. ISSN  2198-3844. PMC  10037956. PMID  36628538.
  325. ^ "Israeli scientists develop sniffing robot with locust antennae". Reuters. 7 February 2023. Retrieved 28 March 2023.
  326. ^ Neta, Shvil; Ariel, Golan; Yossi, Yovel; Amir, Ayali; Ben, Maoz M. (1 February 2023). "The Locust antenna as an odor discriminator". Biosensors and Bioelectronics. 221: 114919. doi: 10.1016/j.bios.2022.114919. ISSN  0956-5663. PMID  36446198. S2CID  253790885.
  327. ^ Hoffmann, Stefan A.; Diggans, James; Densmore, Douglas; Dai, Junbiao; Knight, Tom; Leproust, Emily; Boeke, Jef D.; Wheeler, Nicole; Cai, Yizhi (17 March 2023). "Safety by design: Biosafety and biosecurity in the age of synthetic genomics". iScience. 26 (3): 106165. Bibcode: 2023iSci...26j6165H. doi: 10.1016/j.isci.2023.106165. ISSN  2589-0042. PMC  9988571. PMID  36895643.
  328. ^ Firtina, Nergis (24 February 2023). "3D printable ink containing bacteria will be used in many fields". Retrieved 27 March 2023.
  329. ^ Hirsch, Matteo; Lucherini, Lorenzo; Zhao, Ran; Clarà Saracho, Alexandra; Amstad, Esther (1 January 2023). "3D printing of living structural biocomposites". Materials Today. 62: 21–32. doi: 10.1016/j.mattod.2023.02.001. ISSN  1369-7021.
  330. ^ "A gel cocktail uses the body's sugars to 'grow' electrodes in living fish". Science News. 23 February 2023. Retrieved 26 March 2023.
  331. ^ Strakosas, Xenofon; Biesmans, Hanne; Abrahamsson, Tobias; Hellman, Karin; Ejneby, Malin Silverå; Donahue, Mary J.; Ekström, Peter; Ek, Fredrik; Savvakis, Marios; Hjort, Martin; Bliman, David; Linares, Mathieu; Lindholm, Caroline; Stavrinidou, Eleni; Gerasimov, Jennifer Y.; Simon, Daniel T.; Olsson, Roger; Berggren, Magnus (24 February 2023). "Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics". Science. 379 (6634): 795–802. Bibcode: 2023Sci...379..795S. doi: 10.1126/science.adc9998. ISSN  0036-8075. PMID  36821679. S2CID  257103107.
  332. ^ Strickland, Ashley. "Move over, artificial intelligence. Scientists announce a new 'organoid intelligence' field". CNN. Retrieved 25 March 2023.
  333. ^ Smirnova, Lena; Caffo, Brian S.; Gracias, David H.; Huang, Qi; Morales Pantoja, Itzy E.; Tang, Bohao; Zack, Donald J.; Berlinicke, Cynthia A.; Boyd, J. Lomax; Harris, Timothy D.; Johnson, Erik C.; Kagan, Brett J.; Kahn, Jeffrey; Muotri, Alysson R.; Paulhamus, Barton L.; Schwamborn, Jens C.; Plotkin, Jesse; Szalay, Alexander S.; Vogelstein, Joshua T.; Worley, Paul F.; Hartung, Thomas (28 February 2023). "Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish". Frontiers in Science. 1: 1017235. doi: 10.3389/fsci.2023.1017235. ISSN  2813-6330.
  334. ^ "Human brain cells used as living AIs to solve mathematical equations". New Scientist. Retrieved 18 April 2023.
  335. ^ Cai, Hongwei; Ao, Zheng; Tian, Chunhui; Wu, Zhuhao; Liu, Hongcheng; Tchieu, Jason; Gu, Mingxia; Mackie, Ken; Guo, Feng (1 March 2023). "Brain Organoid Computing for Artificial Intelligence". BioRxiv: The Preprint Server for Biology: 2023.02.28.530502. doi: 10.1101/2023.02.28.530502. PMC  10002682. PMID  36909615.
  336. ^ Yu, Andi (9 March 2023). "Scientists have found an enzyme that can make electricity out of tiny amounts of hydrogen". ABC News. Retrieved 20 April 2023.
  337. ^ Grinter, Rhys; Kropp, Ashleigh; Venugopal, Hari; Senger, Moritz; Badley, Jack; Cabotaje, Princess R.; Jia, Ruyu; Duan, Zehui; Huang, Ping; Stripp, Sven T.; Barlow, Christopher K.; Belousoff, Matthew; Shafaat, Hannah S.; Cook, Gregory M.; Schittenhelm, Ralf B.; Vincent, Kylie A.; Khalid, Syma; Berggren, Gustav; Greening, Chris (March 2023). "Structural basis for bacterial energy extraction from atmospheric hydrogen". Nature. 615 (7952): 541–547. Bibcode: 2023Natur.615..541G. doi: 10.1038/s41586-023-05781-7. ISSN  1476-4687. PMC  10017518. PMID  36890228.
  338. ^ Wickelgren, Ingrid. "Bacterial 'Nanosyringe' Could Deliver Gene Therapy to Human Cells". Scientific American. Retrieved 20 April 2023.
  339. ^ Kreitz, Joseph; Friedrich, Mirco J.; Guru, Akash; Lash, Blake; Saito, Makoto; Macrae, Rhiannon K.; Zhang, Feng (April 2023). "Programmable protein delivery with a bacterial contractile injection system". Nature. 616 (7956): 357–364. Bibcode: 2023Natur.616..357K. doi: 10.1038/s41586-023-05870-7. ISSN  1476-4687. PMC  10097599. PMID  36991127.
  340. ^ "Auf dem Weg in die Matrix: Mikroboboter loggt sich in neuronale Netzwerke ein | MDR.DE". MDR (in German). Retrieved 19 April 2023.
  341. ^ Kim, Eunhee; Jeon, Sungwoong; Yang, Yoon‐Sil; Jin, Chaewon; Kim, Jin‐young; Oh, Yong‐Seok; Rah, Jong‐Cheol; Choi, Hongsoo (March 2023). "A Neurospheroid‐Based Microrobot for Targeted Neural Connections in a Hippocampal Slice". Advanced Materials. 35 (13): 2208747. Bibcode: 2023AdM....3508747K. doi: 10.1002/adma.202208747. ISSN  0935-9648. PMID  36640750. S2CID  257774877.
  342. ^ Yang, Yaoheng; Yuan, Jinyun; Field, Rachael L.; Ye, Dezhuang; Hu, Zhongtao; Xu, Kevin; Xu, Lu; Gong, Yan; Yue, Yimei; Kravitz, Alexxai V.; Bruchas, Michael R.; Cui, Jianmin; Brestoff, Jonathan R.; Chen, Hong (May 2023). "Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound". Nature Metabolism. 5 (5): 789–803. doi: 10.1038/s42255-023-00804-z. ISSN  2522-5812. PMC  10229429. PMID  37231250.
  343. ^ Heidt, Amanda (30 June 2023). "Meet 'Fanzor,' the 1st CRISPR-like system found in complex life". Retrieved 26 July 2023.
  344. ^ Saito, Makoto; Xu, Peiyu; Faure, Guilhem; Maguire, Samantha; Kannan, Soumya; Altae-Tran, Han; Vo, Sam; Desimone, AnAn; Macrae, Rhiannon K.; Zhang, Feng (28 June 2023). "Fanzor is a eukaryotic programmable RNA-guided endonuclease". Nature. 620 (7974): 660–668. Bibcode: 2023Natur.620..660S. doi: 10.1038/s41586-023-06356-2. ISSN  1476-4687. PMC  10432273. PMID  37380027. S2CID  259286102.
  345. ^ "Eukaryotes Have CRISPR-Like Systems That Can Edit Genomes, MIT Teams Report". GenomeWeb. 28 June 2023. Retrieved 26 July 2023.
  346. ^ Jiang, Kaiyi; Lim, Justin; Sgrizzi, Samantha; Trinh, Michael; Kayabolen, Alisan; Yutin, Natalya; Koonin, Eugene V.; Abudayyeh, Omar O.; Gootenberg, Jonathan S. (2023). "Programmable RNA-guided endonucleases are widespread in eukaryotes and their viruses". BioRxiv: The Preprint Server for Biology. doi: 10.1101/2023.06.13.544871. PMC  10312701. PMID  37398409.
  347. ^ Mathiesen, Barbara K.; Miyakoshi, Leo M.; Cederroth, Christopher R.; Tserga, Evangelia; Versteegh, Corstiaen; Bork, Peter A. R.; Hauglund, Natalie L.; Gomolka, Ryszard Stefan; Mori, Yuki; Edvall, Niklas K.; Rouse, Stephanie; Møllgård, Kjeld; Holt, Jeffrey R.; Nedergaard, Maiken; Canlon, Barbara (28 June 2023). "Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice". Science Translational Medicine. 15 (702): eabq3916. doi: 10.1126/scitranslmed.abq3916. ISSN  1946-6234. PMID  37379370. S2CID  259275398.
  348. ^ Ferreira, Becky (11 July 2023). "Scientists Create 'Biological Camera' That Stores Images in DNA". Vice. Retrieved 31 August 2023.
  349. ^ Lim, Cheng Kai; Yeoh, Jing Wui; Kunartama, Aurelius Andrew; Yew, Wen Shan; Poh, Chueh Loo (3 July 2023). "A biological camera that captures and stores images directly into DNA". Nature Communications. 14 (1): 3921. Bibcode: 2023NatCo..14.3921L. doi: 10.1038/s41467-023-38876-w. ISSN  2041-1723. PMC  10318082. PMID  37400476.
  350. ^ "Building a better forest tree with CRISPR gene editing". EurekAlert!. 13 July 2023. Retrieved 15 July 2023.
  351. ^ Sulis, Daniel B.; Jiang, Xiao; Yang, Chenmin; Marques, Barbara M.; Matthews, Megan L.; Miller, Zachary; Lan, Kai; Cofre-Vega, Carlos; Liu, Baoguang; Sun, Runkun; Sederoff, Henry; Bing, Ryan G.; Sun, Xiaoyan; Williams, Cranos M.; Jameel, Hasan; Phillips, Richard; Chang, Hou-min; Peszlen, Ilona; Huang, Yung-Yun; Li, Wei; Kelly, Robert M.; Sederoff, Ronald R.; Chiang, Vincent L.; Barrangou, Rodolphe; Wang, Jack P. (14 July 2023). "Multiplex CRISPR editing of wood for sustainable fiber production". Science. 381 (6654): 216–221. Bibcode: 2023Sci...381..216S. doi: 10.1126/science.add4514. PMC 10542590. PMID  37440632. S2CID  259844575.
  352. ^ Mi, Junpeng; Zhou, Yizhong; Ma, Sanyuan; Zhou, Xingping; Xu, Shouying; Yang, Yuchen; Sun, Yuan; Xia, Qingyou; Zhu, Hongnian; Wang, Suyang; Tian, Luyang; Meng, Qing (October 2023). "High-strength and ultra-tough whole spider silk fibers spun from transgenic silkworms". Matter. 6 (10): 3661–3683. doi: 10.1016/j.matt.2023.08.013. S2CID  262157827.
  353. ^ Madani, Ali; Krause, Ben; Greene, Eric R.; Subramanian, Subu; Mohr, Benjamin P.; Holton, James M.; Olmos, Jose Luis; Xiong, Caiming; Sun, Zachary Z.; Socher, Richard; Fraser, James S.; Naik, Nikhil (26 January 2023). "Large language models generate functional protein sequences across diverse families". Nature Biotechnology. 41 (8): 1099–1106. doi: 10.1038/s41587-022-01618-2. ISSN  1546-1696. PMC 10400306. PMID  36702895. S2CID  256304602.
  354. ^ Ichikawa, David M.; Abdin, Osama; Alerasool, Nader; Kogenaru, Manjunatha; Mueller, April L.; Wen, Han; Giganti, David O.; Goldberg, Gregory W.; Adams, Samantha; Spencer, Jeffrey M.; Razavi, Rozita; Nim, Satra; Zheng, Hong; Gionco, Courtney; Clark, Finnegan T.; Strokach, Alexey; Hughes, Timothy R.; Lionnet, Timothee; Taipale, Mikko; Kim, Philip M.; Noyes, Marcus B. (26 January 2023). "A universal deep-learning model for zinc finger design enables transcription factor reprogramming". Nature Biotechnology. 41 (8): 1117–1129. doi: 10.1038/s41587-022-01624-4. ISSN  1546-1696. PMC  10421740. PMID  36702896.
  355. ^ Engineering, Interesting (9 March 2023). "Mycelium beef steaks and poultry whole-cuts see explosive retail growth". Retrieved 23 April 2023.
  356. ^ Papadopoulos, Loukia (19 March 2023). "'Green-life technology': Biodegradable, recyclable glass is finally here". Retrieved 23 April 2023.
  357. ^ Xing, Ruirui; Yuan, Chengqian; Fan, Wei; Ren, Xiaokang; Yan, Xuehai (15 March 2023). "Biomolecular glass with amino acid and peptide nanoarchitectonics". Science Advances. 9 (11): eadd8105. Bibcode: 2023SciA....9D8105X. doi: 10.1126/sciadv.add8105. ISSN  2375-2548. PMC  10022897. PMID  36930715.
  358. ^ McFadden, Christopher (23 March 2023). "Instant beer powder is here thanks to a German monastic brewery". Retrieved 23 April 2023.
  359. ^ Dixit, Mrigakshi (3 April 2023). "New coconut, lemon material could be used to heat and cool our homes". Retrieved 23 April 2023.
  360. ^ Montanari, Céline; Chen, Hui; Lidfeldt, Matilda; Gunnarsson, Josefin; Olsén, Peter; Berglund, Lars A. (27 March 2023). "Sustainable Thermal Energy Batteries from Fully Bio‐Based Transparent Wood". Small. 19 (28): 2301262. doi: 10.1002/smll.202301262. ISSN  1613-6810. PMID  36970834.
  361. ^ Carrington, Damian (28 March 2023). "Meatball from long-extinct mammoth created by food firm". The Guardian. Retrieved 23 April 2023.
  362. ^ Singer, Peter (24 May 2023). "The Meat Paradox". The Atlantic. Retrieved 28 May 2023.
  363. ^ Bryce, Emma (21 April 2023). "Lab-grown meat gets a key missing ingredient: 3D Fat". Retrieved 28 May 2023.
  364. ^ Yuen Jr, John Se Kit; Saad, Michael K; Xiang, Ning; Barrick, Brigid M; DiCindio, Hailey; Li, Chunmei; Zhang, Sabrina W; Rittenberg, Miriam; Lew, Emily T; Zhang, Kevin Lin; Leung, Glenn; Pietropinto, Jaymie A; Kaplan, David L (4 April 2023). "Aggregating in vitro-grown adipocytes to produce macroscale cell-cultured fat tissue with tunable lipid compositions for food applications". eLife. 12: e82120. doi: 10.7554/eLife.82120. ISSN  2050-084X. PMC  10072877. PMID  37014056.
  365. ^ Jiang, Xiaoxiao; Yan, Chunlong; Zhang, Hanlin; Chen, Li; Jiang, Rui; Zheng, Kexin; Jin, Wanzhu; Ma, Huijuan; Liu, Xiaomeng; Dong, Meng (11 April 2023). "Oral Probiotic Expressing Human Ethanol Dehydrogenase Attenuates Damage Caused by Acute Alcohol Consumption in Mice". Microbiology Spectrum. 11 (3): e0429422. doi: 10.1128/spectrum.04294-22. ISSN  2165-0497. PMC  10269551. PMID  37039510.
  366. ^ Hao, Liangliang; Zhao, Renee T.; Welch, Nicole L.; Tan, Edward Kah Wei; Zhong, Qian; Harzallah, Nour Saida; Ngambenjawong, Chayanon; Ko, Henry; Fleming, Heather E.; Sabeti, Pardis C.; Bhatia, Sangeeta N. (24 April 2023). "CRISPR-Cas-amplified urinary biomarkers for multiplexed and portable cancer diagnostics". Nature Nanotechnology. 18 (7): 798–807. Bibcode: 2023NatNa..18..798H. doi: 10.1038/s41565-023-01372-9. ISSN  1748-3395. PMC  10359190. PMID  37095220.
  367. ^ Dama, Adam C.; Kim, Kevin S.; Leyva, Danielle M.; Lunkes, Annamarie P.; Schmid, Noah S.; Jijakli, Kenan; Jensen, Paul A. (June 2023). "BacterAI maps microbial metabolism without prior knowledge". Nature Microbiology. 8 (6): 1018–1025. doi: 10.1038/s41564-023-01376-0. ISSN  2058-5276. PMID  37142775. S2CID  258508291.
  368. ^ Theodoris, Christina V.; Xiao, Ling; Chopra, Anant; Chaffin, Mark D.; Al Sayed, Zeina R.; Hill, Matthew C.; Mantineo, Helene; Brydon, Elizabeth M.; Zeng, Zexian; Liu, X. Shirley; Ellinor, Patrick T. (June 2023). "Transfer learning enables predictions in network biology". Nature. 618 (7965): 616–624. Bibcode: 2023Natur.618..616T. doi: 10.1038/s41586-023-06139-9. ISSN  1476-4687. PMID  37258680. S2CID  259002047.
  369. ^ Thompson, Joanna. "Lab-Grown Meat Approved for Sale: What You Need to Know". Scientific American. Retrieved 27 July 2023.
  370. ^ "Soya beans made more meat-like by adding genes for pig proteins". New Scientist. Retrieved 27 July 2023.
  371. ^ Watson, Joseph L.; Juergens, David; Bennett, Nathaniel R.; Trippe, Brian L.; Yim, Jason; Eisenach, Helen E.; Ahern, Woody; Borst, Andrew J.; Ragotte, Robert J.; Milles, Lukas F.; Wicky, Basile I. M.; Hanikel, Nikita; Pellock, Samuel J.; Courbet, Alexis; Sheffler, William; Wang, Jue; Venkatesh, Preetham; Sappington, Isaac; Torres, Susana Vázquez; Lauko, Anna; De Bortoli, Valentin; Mathieu, Emile; Ovchinnikov, Sergey; Barzilay, Regina; Jaakkola, Tommi S.; DiMaio, Frank; Baek, Minkyung; Baker, David (August 2023). "De novo design of protein structure and function with RFdiffusion". Nature. 620 (7976): 1089–1100. Bibcode: 2023Natur.620.1089W. doi: 10.1038/s41586-023-06415-8. ISSN  1476-4687. PMC  10468394. PMID  37433327.
  372. ^ Puthussery, Joseph V.; Ghumra, Dishit P.; McBrearty, Kevin R.; Doherty, Brookelyn M.; Sumlin, Benjamin J.; Sarabandi, Amirhossein; Mandal, Anushka Garg; Shetty, Nishit J.; Gardiner, Woodrow D.; Magrecki, Jordan P.; Brody, David L.; Esparza, Thomas J.; Bricker, Traci L.; Boon, Adrianus C. M.; Yuede, Carla M.; Cirrito, John R.; Chakrabarty, Rajan K. (10 July 2023). "Real-time environmental surveillance of SARS-CoV-2 aerosols". Nature Communications. 14 (1): 3692. Bibcode: 2023NatCo..14.3692P. doi: 10.1038/s41467-023-39419-z. ISSN  2041-1723. PMC  10333287. PMID  37429842.
  373. ^ Hu, Jiacheng; Sun, Yu; Li, Boshu; Liu, Zhen; Wang, Zhiwei; Gao, Qiang; Guo, Mengyue; Liu, Guanwen; Zhao, Kevin Tianmeng; Gao, Caixia (28 August 2023). "Strand-preferred base editing of organellar and nuclear genomes using CyDENT". Nature Biotechnology: 1–10. doi: 10.1038/s41587-023-01910-9. ISSN  1546-1696. PMID  37640945. S2CID  261318917.
  374. ^ Li, Tianyu; Menegatti, Stefano; Crook, Nathan (14 September 2023). "Breakdown of polyethylene therepthalate microplastics under saltwater conditions using engineered Vibrio natriegens". AIChE Journal. doi: 10.1002/aic.18228. ISSN  0001-1541. S2CID  261929494.
  375. ^ "Ants can 'sniff out' cancer in urine, scientists find". Sky News. Archived from the original on 16 February 2023. Retrieved 16 February 2023.
  376. ^ Piqueret, Baptiste; Montaudon, Élodie; Devienne, Paul; Leroy, Chloé; Marangoni, Elisabetta; Sandoz, Jean-Christophe; d'Ettorre, Patrizia (25 January 2023). "Ants act as olfactory bio-detectors of tumours in patient-derived xenograft mice". Proceedings of the Royal Society B: Biological Sciences. 290 (1991): 20221962. doi: 10.1098/rspb.2022.1962. ISSN  0962-8452. PMC 9874262. PMID  36695032.
  377. ^ Sanmarco, Liliana M.; Rone, Joseph M.; Polonio, Carolina M.; Fernandez Lahore, Gonzalo; Giovannoni, Federico; Ferrara, Kylynne; Gutierrez-Vazquez, Cristina; Li, Ning; Sokolovska, Anna; Plasencia, Agustin; Faust Akl, Camilo; Nanda, Payal; Heck, Evelin S.; Li, Zhaorong; Lee, Hong-Gyun; Chao, Chun-Cheih; Rejano-Gordillo, Claudia M.; Fonseca-Castro, Pedro H.; Illouz, Tomer; Linnerbauer, Mathias; Kenison, Jessica E.; Barilla, Rocky M.; Farrenkopf, Daniel; Stevens, Nikolas A.; Piester, Gavin; Chung, Elizabeth N.; Dailey, Lucas; Kuchroo, Vijay K.; Hava, David; Wheeler, Michael A.; Clish, Clary; Nowarski, Roni; Balsa, Eduardo; Lora, Jose M.; Quintana, Francisco J. (August 2023). "Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells". Nature. 620 (7975): 881–889. Bibcode: 2023Natur.620..881S. doi: 10.1038/s41586-023-06409-6. ISSN  1476-4687. PMID  37558878. S2CID  260773893.
  378. ^ Cooper, Robert M.; Wright, Josephine A.; Ng, Jia Q.; Goyne, Jarrad M.; Suzuki, Nobumi; Lee, Young K.; Ichinose, Mari; Radford, Georgette; Ryan, Feargal J.; Kumar, Shalni; Thomas, Elaine M.; Vrbanac, Laura; Knight, Rob; Woods, Susan L.; Worthley, Daniel L.; Hasty, Jeff (11 August 2023). "Engineered bacteria detect tumor DNA". Science. 381 (6658): 682–686. Bibcode: 2023Sci...381..682C. bioRxiv  10.1101/2021.09.10.459858. doi: 10.1126/science.adf3974. ISSN  0036-8075. PMID  37561843. S2CID  260776388.
  379. ^ "'It's perfect': World's first generative AI-designed COVID drug to start clinical trials". The Star. 23 February 2023. Retrieved 24 February 2023.
  380. ^ Zhang, He; Zhang, Liang; Lin, Ang; Xu, Congcong; Li, Ziyu; Liu, Kaibo; Liu, Boxiang; Ma, Xiaopin; Zhao, Fanfan; Jiang, Huiling; Chen, Chunxiu; Shen, Haifa; Li, Hangwen; Mathews, David H.; Zhang, Yujian; Huang, Liang (2 May 2023). "Algorithm for Optimized mRNA Design Improves Stability and Immunogenicity" (PDF). Nature. 621 (7978): 396–403. Bibcode: 2023Natur.621..396Z. doi: 10.1038/s41586-023-06127-z. ISSN  1476-4687. PMC  10499610. PMID  37130545. S2CID  247594015.
  381. ^ "New superbug-killing antibiotic discovered using AI". BBC News. 25 May 2023. Retrieved 25 May 2023.
  382. ^ Liu, Gary; Catacutan, Denise B.; Rathod, Khushi; Swanson, Kyle; Jin, Wengong; Mohammed, Jody C.; Chiappino-Pepe, Anush; Syed, Saad A.; Fragis, Meghan; Rachwalski, Kenneth; Magolan, Jakob; Surette, Michael G.; Coombes, Brian K.; Jaakkola, Tommi; Barzilay, Regina; Collins, James J.; Stokes, Jonathan M. (25 May 2023). "Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii". Nature Chemical Biology. 19 (11): 1342–1350. doi: 10.1038/s41589-023-01349-8. ISSN  1552-4469. PMID  37231267. S2CID  258909341.
  383. ^ "AI algorithms find drugs that could combat ageing". University of Edinburgh. 14 June 2023. Retrieved 16 June 2023.
  384. ^ Smer-Barreto, Vanessa; Quintanilla, Andrea; Elliott, Richard J. R.; Dawson, John C.; Sun, Jiugeng; Campa, Víctor M.; Lorente-Macías, Álvaro; Unciti-Broceta, Asier; Carragher, Neil O.; Acosta, Juan Carlos; Oyarzún, Diego A. (10 June 2023). "Discovery of senolytics using machine learning". Nature Communications. 14 (1): 3445. Bibcode: 2023NatCo..14.3445S. doi: 10.1038/s41467-023-39120-1. ISSN  2041-1723. PMC  10257182. PMID  37301862.
  385. ^ Arnold, Carrie (1 June 2023). "Inside the nascent industry of AI-designed drugs". Nature Medicine. 29 (6): 1292–1295. doi: 10.1038/s41591-023-02361-0. PMID  37264208. S2CID  259025019.
  386. ^ "Researchers perform first successful transplant of functional cryopreserved rat kidney". University of Minnesota. 22 June 2023. Retrieved 25 June 2023.
  387. ^ Han, Zonghu; Rao, Joseph Sushil; Gangwar, Lakshya; Namsrai, Bat-Erdene; Pasek-Allen, Jacqueline L.; Etheridge, Michael L.; Wolf, Susan M.; Pruett, Timothy L.; Bischof, John C.; Finger, Erik B. (9 June 2023). "Vitrification and nanowarming enable long-term organ cryopreservation and life-sustaining kidney transplantation in a rat model". Nature Communications. 14 (1): 3407. Bibcode: 2023NatCo..14.3407H. doi: 10.1038/s41467-023-38824-8. ISSN  2041-1723. PMC  10256770. PMID  37296144.