1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an
enzyme that in humans is encoded by the PLCB2gene.[5][6][7]
Function
The gene codes for the enzyme
phospholipase C β2. The enzyme catalyzes the formation of
inositol 1,4,5-trisphosphate and
diacylglycerol from
phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two
G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.
^Park SH, Ryu SH, Suh PG, Kim H (Mar 1999). "Assignment1 of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridization". Cytogenet. Cell Genet. 83 (1–2): 48–9.
doi:
10.1159/000015166.
PMID9925923.
S2CID45169136.
Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S (1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". Eur. J. Immunol. 25 (9): 2695–700.
doi:
10.1002/eji.1830250944.
PMID7589147.
S2CID20562627.
Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92.
doi:
10.1159/000026336.
PMID9730685.
S2CID19529677.
Haughey NJ, Holden CP, Nath A, Geiger JD (1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". J. Neurochem. 73 (4): 1363–74.
doi:
10.1046/j.1471-4159.1999.0731363.x.
PMID10501179.
S2CID25410140.
Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC (2000). "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)". Biochim. Biophys. Acta. 1517 (1): 63–72.
doi:
10.1016/S0167-4781(00)00260-8.
PMID11118617.
Singer AU, Waldo GL, Harden TK, Sondek J (2002). "A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q". Nat. Struct. Biol. 9 (1): 32–6.
doi:
10.1038/nsb731.
PMID11753430.
S2CID13301839.
Runnels LW, Yue L, Clapham DE (2002). "The TRPM7 channel is inactivated by PIP(2) hydrolysis". Nat. Cell Biol. 4 (5): 329–36.
doi:
10.1038/ncb781.
PMID11941371.
S2CID21592843.
Scarlata S (2002). "Regulation of the lateral association of phospholipase Cbeta2 and G protein subunits by lipid rafts". Biochemistry. 41 (22): 7092–9.
doi:
10.1021/bi025625j.
PMID12033943.
Bertagnolo V, Marchisio M, Pierpaoli S, Colamussi ML, Brugnoli F, Visani G, Zauli G, Capitani S (2002). "Selective up-regulation of phospholipase C-beta2 during granulocytic differentiation of normal and leukemic hematopoietic progenitors". J. Leukoc. Biol. 71 (6): 957–65.
doi:
10.1189/jlb.71.6.957.
PMID12050180.
S2CID37477730.
Barr AJ, Marjoram R, Xu J, Snyderman R (2002). "Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3". Biochem. Biophys. Res. Commun. 293 (1): 647–52.
doi:
10.1016/S0006-291X(02)00259-0.
PMID12054652.