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Langat virus
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Kitrinoviricota
Class: Flasuviricetes
Order: Amarillovirales
Family: Flaviviridae
Genus: Flavivirus
Species:
Langat virus

Langat virus (LGTV) is a virus of the genus Flavivirus. The virus was first isolated in Malaysia in 1956 from a hard tick of the Ixodes genus. [1] This virus is antigenically related to Omsk hemorrhagic fever virus, Kyasanur forest disease virus, Alkhurma virus, Louping ill virus and other viruses of the tick-borne encephalitis virus (TBEV) complex. The Langat virus does not pose a significant epidemiological threat in comparison with TBEV. There are no known cases of human diseases associated with LGTV. [2] The Malaysian strain (LGT strain TP21, also known as the Yelantsev virus) is naturally attenuated and induces neutralizing antibodies to tick-borne encephalitis virus (TBEV) and protection against other TBEV complex viruses in animals. [3]

LGTV-based vaccine

In the 1970s a live attenuate LGTV-based vaccine against tick-borne encephalitis was made. At the same time, another vaccine was tested, but the group vaccinated with the LGTV-based vaccine had the lowest level of developing infection decease. [4] However, there were two major problems: the relatively high rate of incidents of encephalitis (1:10,000) and lack of absolute protection from infection in endemic regions.[ citation needed]

References

  1. ^ Smith, CE (15 September 1956). "A virus resembling Russian spring-summer encephalitis virus from an ixodid tick in Malaya". Nature. 178 (4533): 581–2. Bibcode: 1956Natur.178..581G. doi: 10.1038/178581a0. PMID  13369466. S2CID  4272594.
  2. ^ Gritsun TS, Lashkevich VA, Gould EA (January 2003). "Tick-borne encephalitis". Antiviral Res. 57 (1–2): 129–46. doi: 10.1016/S0166-3542(02)00206-1. PMID  12615309.
  3. ^ Rumyantsev, A. A.; Murphy, B. R.; Pletnev, A. G. (13 January 2006). "A Tick-Borne Langat Virus Mutant That Is Temperature Sensitive and Host Range Restricted in Neuroblastoma Cells and Lacks Neuroinvasiveness for Immunodeficient Mice". Journal of Virology. 80 (3): 1427–39. doi: 10.1128/JVI.80.3.1427-1439.2006. PMC  1346960. PMID  16415020.
  4. ^ Shapoval AN; Kamalov II; Denisova EIu; Sokolova ED; Luzin PM; Shamarina AG; Gusmanova AG; Pinaeva NI (1989). "Study of the distant consequences of immunizing people with a live vaccine against tick-borne encephalitis". Tr Inst Im Pastera (in Russian). 65: 133–5. PMID  2629181.