From Wikipedia, the free encyclopedia
Irish geneticist and academic
Kenneth Henry Wolfe
FRS
MRIA
[11]
[12] is an Irish geneticist and professor of
genomic evolution at
University College Dublin (UCD),
Ireland .
[13]
[11]
[14]
Education
Wolfe was educated at
Trinity College Dublin , where he was awarded
Bachelor of Arts degree in
genetics in 1986
[3] followed by a
PhD in 1990
[6] for research investigating
synonymous substitution in
vascular plants and
mammals supervised by
Paul M. Sharp .
[4]
[5]
[6]
[15]
Research and career
Wolfe's research focuses on
comparative genomics ,
yeast
genetics and
bioinformatics .
[2]
[16]
[17] Work in his laboratory investigates the
evolution of
eukaryotic
genomes and
chromosome organisation.
[12] He is best known for his discovery that the genome of the yeast
Saccharomyces cerevisiae underwent complete
genome duplication about 100 million years ago,
[18] an event that is now known to be the result of
hybridization between two
divergent species .
[12] This finding reshaped our understanding both of
yeast biology , and of mechanisms of
genome evolution in eukaryotes.
[12] His subsequent discoveries of similar
ancient genome duplications (paleopolyploidy)
[19] during
human evolution , and in almost all families of
flowering plants , led to the realisation that whole-genome duplication is widespread.
[12] His group also studies the origin and evolution of
mating systems in yeasts, and the process of
mating-type switching in which one cell type can change into another by moving or replacing a section of chromosome.
[12]
Wolfe was a
postdoctoral researcher with
Jeffrey D. Palmer
[7] at
Indiana University Bloomington before returning to Ireland in 1992 to establish his research group in the genetics department of Trinity College Dublin,
[20]
[3] where he remained for over 20 years. In 2013, he moved to
University College Dublin 's UCD School of Medicine and Conway Institute.
[21] As of 2017
[update] his most highly cited
peer reviewed papers
[2]
[14]
[16] have been published in leading
scientific journals including
Nature ,
[18]
[22]
PNAS ,
[23]
The Plant Cell ,
[19]
[24]
Genome Research
[25] and
Nature Reviews Genetics .
[7]
Former doctoral students from the Wolfe lab include Mario A. Fares,
[4]
Aoife McLysaght ,
[4]
[8]
[9] Estelle Proux-Wéra
[4] and Cathal Seoighe.
[5]
[10]
Awards and honours
Wolfe was elected a
Fellow of the Royal Society (FRS) in 2017 ,
[12] a member of the
Royal Irish Academy (MRIA) in 2000
[11] and a member of the
European Molecular Biology Organization (EMBO) in 2010.
[1] In 2011 he served as president of the
Society for Molecular Biology and Evolution (smbe.org) .
[26]
References
^
a
b Anon (2010).
"EMBO member: Kenneth H. Wolfe" . people.embo.org . Heidelberg:
European Molecular Biology Organization . Archived from
the original on 31 January 2017.
^
a
b
c
Kenneth H. Wolfe publications indexed by
Google Scholar
^
a
b
c Ken Wolfe's
ORCID
0000-0003-4992-4979
^
a
b
c
d
e
f
g
h Anon (2017).
"Kenneth H. Wolfe academic genealogy" . academictree.org . Archived from
the original on 11 July 2017.
^
a
b
c
d
Kenneth H. Wolfe at the
Mathematics Genealogy Project
^
a
b
c Wolfe, Kenneth H. (1990).
Rates of nucleotide substitution in higher plants and mammals (PhD thesis). Trinity College Dublin.
OCLC
842511087 .
Copac
11666046 .
^
a
b
c Wolfe, Kenneth H. (2001). "Yesterday's polyploids and the mystery of diploidization". Nature Reviews Genetics . 2 (5): 333–341.
doi :
10.1038/35072009 .
ISSN
1471-0056 .
PMID
11331899 .
S2CID
20796914 . (subscription required)
^
a
b McLysaght, Aoife (2002).
Evolution of vertebrate genome organisation (PDF) (PhD thesis). Trinity College Dublin.
OCLC
842498402 .
Copac
11660313 . Archived from
the original (PDF) on 6 November 2017.
^
a
b Wolfe, Ken (2017).
"Wolfe lab alumni" . wolfe.ucd.ie . Archived from
the original on 11 July 2017.
^
a
b Seoighe, Cathal (2000). Gene order evolution and genomic analysis of the model eukaryote, Saccharomyces cerevisiae, and other yeast species (PhD thesis). Trinity College Dublin.
OCLC
842501444 .
Copac
11661350
ProQuest
301607379 .
^
a
b
c Anon (2000).
"Kenneth H. Wolfe FTCD" . ria.ie . Dublin:
Royal Irish Academy . Archived from
the original on 11 December 2017. Retrieved 14 July 2017 .
^
a
b
c
d
e
f
g Anon (2017).
"Professor Kenneth Wolfe FRS" . royalsociety.org . London:
Royal Society . Archived from
the original on 5 May 2017. One or more of the preceding sentences incorporates text from the royalsociety.org website where: "All text published under the heading 'Biography' on Fellow profile pages is available under
Creative Commons Attribution 4.0 International License ." --
"Royal Society Terms, conditions and policies" . Archived from the original on 11 November 2016. Retrieved 9 March 2016 . {{
cite web }}
: CS1 maint: bot: original URL status unknown (
link )
^
UCD Professor Kenneth Wolfe elected Fellow of the Royal Society on
YouTube , University College Dublin
^
a
b
Kenneth H. Wolfe publications from
Europe PubMed Central
^ Sharp, Paul M.; Cowe, Elizabeth;
Higgins, Desmond G. ; Shields, Denis C.; Wolfe, Kenneth H.; Wright, Frank (1988).
"Codon usage patterns in Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Drosophila melanogaster and Homo sapiens; a review of the considerable within-species diversity" .
Nucleic Acids Research . 16 (17): 8207–8211.
doi :
10.1093/nar/16.17.8207 .
ISSN
0305-1048 .
PMC
338553 .
PMID
3138659 .
^
a
b
Kenneth H. Wolfe publications indexed by the
Scopus bibliographic database. (subscription required)
^ Sherlock, Gavin; Schröder, Markus S.; Martinez de San Vicente, Kontxi; Prandini, Tâmara H. R.; Hammel, Stephen;
Higgins, Desmond G. ; Bagagli, Eduardo; Wolfe, Kenneth H.; Butler, Geraldine (2016).
"Multiple Origins of the Pathogenic Yeast Candida orthopsilosis by Separate Hybridizations between Two Parental Species" .
PLOS Genetics . 12 (11): e1006404.
doi :
10.1371/journal.pgen.1006404 .
ISSN
1553-7404 .
PMC
5091853 .
PMID
27806045 .
^
a
b Wolfe, Kenneth H.; Shields, Denis C. (1997).
"Molecular evidence for an ancient duplication of the entire yeast genome" . Nature . 387 (6634): 708–713.
Bibcode :
1997Natur.387..708W .
doi :
10.1038/42711 .
ISSN
0028-0836 .
PMID
9192896 .
S2CID
4307263 . (subscription required)
^
a
b Blanc, Guillaume; Wolfe, Kenneth H. (2004).
"Widespread Paleopolyploidy in Model Plant Species Inferred from Age Distributions of Duplicate Genes" . The Plant Cell . 16 (7): 1667–1678.
doi :
10.1105/tpc.021345 .
ISSN
1040-4651 .
PMC
514152 .
PMID
15208399 .
^
"Trinity College Dublin Genetics Department" . www.tcd.ie .
^
"Ken Wolfe Profile" . people.ucd.ie .
^
Lander, E. S. ; Linton, M.; Birren, B.; Nusbaum, C.; Zody, C.; Baldwin, J.; Devon, K.; Dewar, K.; Doyle, M.; Fitzhugh, W.; Funke, R.; Gage, D.; Harris, K.; Heaford, A.; Howland, J.; Kann, L.; Lehoczky, J.; Levine, R.; McEwan, P.; McKernan, K.; Meldrim, J.;
Mesirov, J. P. ; Miranda, C.; Morris, W.; Naylor, J.; Raymond, C.; Rosetti, M.; Santos, R.; Sheridan, A.; et al. (2001).
"Initial sequencing and analysis of the human genome" (PDF) . Nature . 409 (6822): 860–921.
Bibcode :
2001Natur.409..860L .
doi :
10.1038/35057062 .
hdl :
2027.42/62798 .
ISSN
0028-0836 .
PMID
11237011 .
^ Wolfe, K. H.; Li, W. H.; Sharp, P. M. (1987).
"Rates of nucleotide substitution vary greatly among plant mitochondrial, chloroplast, and nuclear DNAs" .
Proceedings of the National Academy of Sciences . 84 (24): 9054–9058.
Bibcode :
1987PNAS...84.9054W .
doi :
10.1073/pnas.84.24.9054 .
ISSN
0027-8424 .
PMC
299690 .
PMID
3480529 .
^ Blanc, Guillaume; Wolfe, Kenneth H. (2004).
"Functional Divergence of Duplicated Genes Formed by Polyploidy during Arabidopsis Evolution" . The Plant Cell . 16 (7): 1679–1691.
doi :
10.1105/tpc.021410 .
ISSN
1040-4651 .
PMC
514153 .
PMID
15208398 .
^ Blanc, G.; Hokamp, Karsten; Wolfe, Kenneth H. (2003).
"A Recent Polyploidy Superimposed on Older Large-Scale Duplications in the Arabidopsis Genome" . Genome Research . 13 (2): 137–144.
doi :
10.1101/gr.751803 .
ISSN
1088-9051 .
PMC
420368 .
PMID
12566392 .
^ Anon (2017).
"SMBE Council members" . smbe.org . Archived from
the original on 10 October 2017. Retrieved 22 September 2017 .