Kekū‘iapoiwa I was a chiefess of the island of Hawaiʻi and Maui. She was also known as Kekū‘iapoiwa Nui ("Kekū‘iapoiwa the Great"). Her full name was Kekū‘iapoiwa-nui Kalani-kauhihiwakama Wanakapu.
Kekū‘iapoiwa was born as a daughter of the High Chiefess Kalanikauleleiaiwi, who lived in the late 17th century and early 18th century. She was thus a niece of the king Keaweʻīkekahialiʻiokamoku and granddaughter of the queen Keakealaniwahine. 
Her father was the king Kaulahea II of Maui. She remained on Maui and married her half-brother Kekaulike, founding the Kekaulike Dynasty of Maui which produced many chief politicians and nobles in the early days of the Kingdom of Hawaii.
She was also a sister of Alapainui and Haʻae and aunt of Kekuiapoiwa II, mother of the great king Kamehameha I.
She was a mother of Kamehamehanui Aiʻluau, and Kahekili II and grandmother of Kalanikūpule, the last of the longest line of ʻAliʻi Aimoku in the Hawaiian Islands. There is a theory that Kahekili was a biological father of Kamehameha I. Her daughter by Kekaulike was Kalola who married Kalaniʻōpuʻu and his half-brother Keōua and had Kīwalaʻō and Kekuiapoiwa Liliha respectively. Kekuiapoiwa had another daughter by the name of Kekelaokalani by Kauakahiakua, a distant cousin of her first husband, and Kekelaokalani was the mother of Kamehameha I's wife Peleuli.