Wruble's TEDx Penn talk discussed the issue of doctors treating abnormalities found on tests, leading to expensive further testing and potential overdiagnosis and overtreatment. In light of the COVID-19 pandemic and the reduced availability for elective surgeries in some areas, she is among the doctors calling for a reevaluation of aggressive
cancer screenings and treatment that may cause harm to patients.[9]
She says that with contemporary
CT scans providing a large number of very detailed images, "[w]e now see things that we would have never seen before, like a lesion that may never be a problem"[9] and that it is typical to see multiple abnormalities with each scan.[8] Wruble is concerned with "the unintended consequences of medical testing"[10] and along with co-author
Joann Elmore has written about her skepticism of
computer aided diagnosis as a tool for detecting breast cancer.[11][12] A paper that she contributed to, "Effective Radiology Reporting"[13] is often cited in papers on
incidentaloma.