The Second Federal Electoral District of Baja California Sur (II Distrito Electoral Federal de Baja California Sur) is one of the 300 Electoral Districts into which Mexico is divided for the purpose of elections to the federal Chamber of Deputies and one of two such districts in the state of Baja California Sur.

It elects one deputy to the lower house of Congress for each three-year legislative period, by means of the first past the post system.

District territory

It covers the municipality of Los Cabos and the easternmost third of the municipality of La Paz. The district's head town (cabecera distrital), where results from individual polling stations are gathered together and collated, is the state capital, La Paz.

Deputies returned to Congress from this district

Parties
	PAN
	PRI
	PRD
	PT
	PVEM
	MC
	PANAL
	PSD

• L Legislature
  • 1976–1979: Agapito Duarte Hernández (PRI)
• LI Legislature
  • 1979–1982:
• LII Legislature
  • 1982–1985:
• LIII Legislature
  • 1985–1988: Eligio Soto López (PRI)
• LIV Legislature
  • 1988–1991: Antonio Manríquez Guluarte (PRI)
• LV Legislature
  • 1991–1994: Mario Vargas Aguiar (PRI)
• LVI Legislature
  • 1994–1997: Rodimiro Amaya Téllez (PRI)
• LVII Legislature
  • 1997–2000: Antonio Manríquez Guluarte (PRI)
• LVIII Legislature
  • 2000–2003: Rosa Delia Cota Montaño (PT)
• LIX Legislature
  • 2003–2004: Narciso Agúndez Montaño (PRD)
  • 2004–2006: Josefina Cota Cota (PRD)
• LX Legislature
  • 2006–2009: Víctor Manuel Lizárraga Peraza (PRD)