Derek LeRoith is a South African
endocrinologist and Professor of Medicine and the current Chief of the Hilda and J. Lester Gabrilove, M.D. Division of Endocrinology, Diabetes and Bone Disease and Director of the Metabolism Institute of the
Mount Sinai Medical Center in
New York City.[1] He is an international expert in insulin-like growth factor-1 (IGF-1).[2]
LeRoith was the first to demonstrate the link between
insulin-like growth factor-1 (IGF-1) and
cancer[2] and is the current recipient of an
NCI grant to study the relationship between cancer and
type 2 diabetes. He is the author of more than 500 publications and an editor of more than 20 textbooks on endocrinology.
Diabetes Mellitus: a Fundamental and Clinical text, Derek LeRoith (Editor), Simeon I. Taylor (Editor) and Jerrold M Olefsky (Editor), 2003 (Third Edition),
ISBN0-7817-4097-5
Molecular Biology of Diabetes, Part I: Autoimmunity and Genetics; Insulin Synthesis and Secretion, Boris Draznin (Editor), Derek LeRoith (Editor), 1994,
ISBN0-89603-286-8
Molecular Biology of Diabetes, Part II: Insulin Action, Effects on Gene Expression and Regulation, and Glucose Transport, Boris Draznin (Editor), Derek LeRoith (Editor), 1994,
ISBN0-89603-287-6
Controversies in Treating Diabetes: Clinical and Research Aspects (Contemporary Endocrinology), Derek LeRoith (Editor), Aaron I. Vinik (Editor), 2008,
ISBN1-58829-708-X
Publications
Partial list:
Insulin sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression. Fierz Y, Novosyadlyy R, Vijayakumar A, Yakar S, Leroith D. Diabetes. 3 December 2009.
doi:
10.2337/db09-1291PMID19959755
High-efficient FLPo deleter mice in C57BL/6J background. Wu Y, Wang C, Sun H, LeRoith D, Yakar S. PLoS One. 26 November 2009;4(11):e8054.
doi:
10.1371/journal.pone.0008054PMID19956655
Biological effects of growth hormone on carbohydrate and lipid metabolism. Vijayakumar A, Novosyadlyy R, Wu Y, Yakar S, Leroith D. Growth Horm IGF Res. 30 September 2009.
doi:
10.1016/j.ghir.2009.09.002PMID19800274
Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation. Novosyadlyy R, Vijayakumar A, Lann D, Fierz Y, Kurshan N, LeRoith D. Oncogene. 1 October 2009;28(39):3477-86. Epub 20 July 2009.
doi:
10.1038/onc.2009.209PMID19617901
Elevated levels of insulin-like growth factor (IGF)-I in serum rescue the severe growth retardation of IGF-1 null mice. Wu Y, Sun H, Yakar S, LeRoith D" Endocrinology 2009 Sep;150(9):4395-403. Epub 4 June 2009.
doi:
10.1210/en.2009-0272PMID19497975
Apolipoprotein E deficiency abrogates insulin resistance in a mouse model of type 2 diabetes mellitus. Kawashima Y, Chen J, Sun H, Lann D, Hajjar RJ, Yakar S, Leroith D" Diabetologia 2009 Jul;52(7):1434-41. Epub 13 May 2009.
doi:
10.1007/s00125-009-1378-8PMID19436992
Basic aspects and clinical applicability in the field of lipidology. Foreword. LeRoith D. Endocrinol Metab Clin North Am. 2009 Mar;38(1):xiii-xv.
doi:
10.1016/j.ecl.2009.01.015PMID19217508
Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis. Kawashima Y, Fritton JC, Yakar S, Epstein S, Schaffler MB, Jepsen KJ, LeRoith D" Bone 2009 Apr;44(4):648-55. Epub 24 December 2008.
doi:
10.1016/j.bone.2008.12.012PMID19150422
Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I. Hong SH, Briggs J, Newman R, Hoffman K, Mendoza A, LeRoith D, Helman L, Yakar S, Khanna C. Int J Cancer. 1 May 2009;124(9):2042-9.
doi:
10.1002/ijc.24169PMID19132750
Rationale and strategies for early detection and management of diabetic kidney disease. Radbill B, Murphy B, LeRoith D. Mayo Clin Proc. 2008 Dec;83(12):1373-81. Review.
doi:
10.1016/S0025-6196(11)60786-6PMID19046557
The role of endocrine insulin-like growth factor-I and insulin in breast cancer. Lann D, LeRoith D. J Mammary Gland Biol Neoplasia. 2008 Dec;13(4):371-9. Epub 22 November 2008. Review.
doi:
10.1007/s10911-008-9100-xPMID19030972