Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a
protein that in humans is encoded by the CCL3gene.[3]
Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (
CCL4).[5][3]
CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human
tumor necrosis factor or recombinant human
interleukin-1. However, in contrast to these two endogenous
pyrogens, the fever induced by MIP-1 is not inhibited by the
cyclooxygenase inhibitor
ibuprofen and CCL3 may participate in the
febrile response that is not mediated through
prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.[6]
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PMID15638726.
Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research. 121 (4): 270–86.
PMID15817944.