Schröppel is the author of three book chapters and 44 peer-reviewed articles. He is a member of the
American Society of Nephrology and the American Society of Transplantation.
Biography
Schröppel graduated with his medical degree in from the
University of Ulm, Germany. He completed his residency training at
Albert Einstein College of Medicine in New York, and his nephrology and transplant fellowship at Mount Sinai Hospital.
Schröppel’s research interests are to characterize the innate immune response in transplantation and to identify therapeutic strategies to improve transplant survival. The other focus of his lab is to study molecular tools (
SNP analysis,
gene expression profiling, and differential expression of
microRNA) in order to predict or detect complications (e.g.
rejection, delayed graft function) after clinical transplantation.[citation needed]
He was named medical director of Mount Sinai's kidney and pancreas transplant program in January, 2009.[citation needed]
Grants
Principal investigator, contribution of
toll-like receptor signaling in islet transplantation, NIH/
NIAID[1]
Principal investigator, genetic and immune markers to predict HCV recurrence after liver transplantation. Prospective study in liver transplant recipients to identify genetic and molecular innate immune markers that predict HCV recurrence. American Society of Transplant Surgeons –
Pfizer mid-level faculty award.
Honors and awards
1994 Summa cum laude, University of Ulm, Germany
1997 Fesenius medical thesis research award of the University of Ulm, Germany
1998 Jan Brod research award of the University of Hannover, Germany
2005 American Society of Transplant Surgeons (ASTS) Vanguard Prize[2]
2005 Norman S. Coplon Grant, Satellite Research Award
2007 Louis R. Wasserman Medical Scholar Career Development Award
2009 Dr. Harold and Golden Lamport Research Award
2010 ASTS - Pfizer mid-level faculty award
Book chapters
Schröppel B, Heeger P. Transplantation Immunology. In: Kidney Transplantation State of the Art. Hricik DE (Ed.). Second edition, London, UK: Remedica Group, 2007.
Schröppel B, Akalin E. Transplant Immunology and Immunosuppression. In: Therapy in Nephrology and Hypertension: a companion to Brenner & Rector's The Kidney, Third Edition, by Christopher S. Wilcox, MD, published by Saunders, Elsevier Inc. 2008
Gurkan S, Schröppel B, Murphy B. Immunology of Organ Transplantation. In: Pathology of Organ Transplantation, Springer 2011
Publications
Partial list:
Zhang N, Schröppel B, Lal G, Jakubzick C, Mao X, Chen D, Yin N, Jessberger R, Ochando JC, Ding Y, Bromberg JS. Regulatory T cells sequentially migrate from the site of tissue inflammation to the draining LN to suppress allograft rejection. Immunity, 30:458-469, 2009.
PMID19303390
Krüger B, Krick S, Dhillon N, Lerner S, Ames S, Bromberg JS, Lin M, Walsh L, Vella J, Fischereder M, Krämer B, Colvin RB, Heeger P, Murphy B, Schröppel B. Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation. Proc Natl Acad Sci U S A, 106(9):3390-3395, 2009.
PMID19218437
Ju W, Eichinger F, Bitzer M, Oh J, McWeeney S, Berthier CC, Shedden K, Cohen C, Henger A, Krick S, Kopp J, Stoeckert C, Dikman S, Schröppel B, Thomas D, Schlondorff D, Kretzler M, Bottinger E. Renal Gene and Protein Expression Signatures for Prediction of Kidney Disease Progression. Am J Pathol, 174(6):2073-85, 2009.
PMID19465643
Rafiq MA, de Boccardo G, Schröppel B, Bromberg JS, Sehgal V, Dinavahi R, Murphy B, Akalin E. Differential outcomes in 3 types of acute antibody-mediated rejection. Clin Transplant. 2009.
PMID19624692
Dhillon N, Liron W, Krüger B, Mehrotra A, Ward S, Godbold J, Radwan M, Schiano T, Murphy B, Schröppel B. Complement C3 allotypes and outcomes in liver transplantation. Liver Transplantation, 16:198-203, 2010.
PMID20104494
Schröppel B, Krüger B, Walsh L, Harris S, Garrison K, Himmelfarb J, Lerner S, Bromberg J, Zhang P, Bonventre J, Wang Z, Farris A, Colvin R, Murphy B, Vella J, Tubular expression of KIM-1 does not predict delayed function after transplantation, J Am Soc Nephrol, 21:536-542, 2010.
PMID20019169
Zhang N, Krüger B, Lal G, Luan Y, Yadav A, Zang W, Grimm M, Waaga-Gasser AM, Murphy B, Bromberg JS, Schröppel B. Inhibition of TLR4 signaling prolongs Treg-dependent murine islet allograft survival, Immunol Letters, 127:119-125, 2010.
PMID19879295
Dhillon N, Walsh L, Krüger B, Ward SC, Godbold JH, Radwan M, Schiano T, Murphy BT, Schröppel B. A single nucleotide polymorphism of Toll-like receptor 4 identifies the risk of developing graft failure after liver transplantation. J Hepatology, in press.
PMID20400193
Lin M, Yin N, Murphy B, Medof ME, Segerer S, Heeger PS, Schröppel B. Immune cell-derived c3 is required for autoimmune diabetes induced by multiple low doses of streptozotocin. Diabetes, 59(9):2247-52, 2010.
PMID20584999
Krüger B, Yin N, Zhang N, Yadav A, Coward W, Lal G, Zang W, S Heeger P, Bromberg JS, Murphy B, Schröppel B. Islet-expressed TLR2 and TLR4 sense injury and mediate early graft failure after transplantation. Eur J Immunol, 40(10):2914-24, 2010.
PMID20809521
Gurkan S, Luan Y, Dhillon N, Allam SA, Montague T, Bromberg JS, Ames S, Lerner S, Ebcioglu Z, Nair V, Dinavahi R, Sehgal V, Heeger P, Schröppel B, Murphy B. Immune reconstitution following rabbit antithymocyte globulin. Am J Trans 10:2132-2141, 2010
PMID20883548
Lal G, Yin N, Xu J, Lin M, Schröppel B, Ding Y, Marie I, Levy DE, Bromberg JS. Distinct inflammatory signals have physiologically divergent effects on epigenetic regulation of Foxp3 expression and Treg function, Am J Transplantation, 11(2):203-214, 2011.
PMID21219575
Dinavahi R, George A, Tretin A, Akalin E, Ames S, Bromberg JS, DiPaola N, Lerner S, Mehrotra A, Murphy B, Nadasdy T, Arta E, Salomon DR, Schröppel B, Sehgal V, Sachidanandam R, Heeger P. Antibodies Reactive to Non-HLA Antigens in Transplant Glomerulopathy. JASN, in press