Multidrug resistance-associated protein 9 is a
protein that in humans is encoded by the ABCC12gene.[5][6][7]
Function
This gene is a member of the superfamily of
ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies:
ABC1,
MDR/TAP,
MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with
breast cancer.[7] Loss of function is implicated in hereditary
cholestasis.
^Tammur J, Prades C, Arnould I, Rzhetsky A, Hutchinson A, Adachi M, et al. (Aug 2001). "Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12". Gene. 273 (1): 89–96.
doi:
10.1016/S0378-1119(01)00572-8.
PMID11483364.