From Wikipedia, the free encyclopedia
Chemical compound
4-HO-DET , also known as 4-hydroxy-diethyl-tryptamine , CZ-74 , is a
hallucinogenic drug and
psychedelic compound of moderate duration. 4-HO-DET is a
substituted
tryptamine , structurally related to
psilocin ,
ethocybin , and
4-HO-DIPT .
[1]
Analogs
4-HO-DET is the N,N-diethyl analog of psilocin. The
acetic acid
ester of 4-HO-DET is known as
4-AcO-DET and the
phosphoric acid ester of 4-HO-DET is known as 4-phosphoryloxy-DET, CEY-19, or
ethocybin . These compounds may likely be
prodrugs of 4-HO-DET as has been shown with the acetate and phospate esters of other methylated tryptamines such as psilocin.
[2]
History
4-HO-DET received the lab code CZ-74 in the late 1950s by the inventors of the substance,
Albert Hofmann and
Franz Troxler . The substance was used together with its phosphoryloxy-analog ethocybin in human clinical trials in the 1960s by the German researchers
Hanscarl Leuner and G. Baer.[
citation needed ] It was later explored by Alexander Shulgin in his 1997 book
TiHKAL .
[3]
Dosage
TiHKAL reports moderate effects at 10–25 mg ingested orally.
[4]
Effects
4-HO-DET produces
psychedelic effects similar to
LSD and
psilocybin .
[4]
Legality
United States
4-HO-DET is unscheduled in the United States, but purchase, sale, or possession for human consumption could be prosecuted under the
Federal Analogue Act .
[5]
Sweden
Sveriges riksdags health ministry
Statens folkhälsoinstitut classified 4-HO-DET as "health hazard" under the act
Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health ) as of Nov 1, 2005, in their regulation SFS 2005:733 listed as 4-hydroxi-N,N-diethyltryptamin (4-HO-DET), making it illegal to sell or possess.
[6]
See also
References
^ Greene SL (2021).
"Tryptamines" . In Dargan PI, Wood DM (eds.). Novel Psychoactive Substances: Classification, Pharmacology and Toxicology (Second ed.). London, United Kingdom: Academic Press. p. 499.
ISBN
978-0-12-819030-2 .
^ Nichols DE (February 11, 1999).
"Improvements to the Synthesis of Psilocybin and a Facile Method for Preparing the O-Acetyl Prodrug of Psilocin" . Synthesis . 1999 (6): 935–938.
doi :
10.1055/s-1999-3490 .
S2CID
32044725 .
^
Shulgin, Alexander ;
Shulgin, Ann (September 1997).
TiHKAL: The Continuation .
Berkeley, California : Transform Press.
ISBN
0-9630096-9-9 .
OCLC
38503252 .
^
a
b Shulgin A, Shulgin A (September 1997).
"#16 4-HO-DET" . Isomer Design . Transform Press. Retrieved 28 November 2023 .
^
"21 U.S. Code § 841 - Prohibited acts A" , LII / Legal Information Institute , retrieved 2016-08-02
^
"Förordning om ändring i förordningen (1999:58) om förbud mot vissa hälsofarliga varor;" [Ordinance amending the ordinance (1999: 58) on the prohibition of certain dangerous goods;] (PDF) . Svensk författningssamling (Swedish Code of Statutes) (in Swedish). 6 October 2005. Archived from
the original (PDF) on 26 June 2021. Retrieved 6 September 2013 .
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